Science Daily: Pharmacology News

APRIL 29, 2024

The first study of the use of microarray patches to vaccinate children has shown that the method is safe and induces strong immune responses.

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Vaccine Trials Immune Response 111

Science Daily: Pharmacology News

JUNE 18, 2024

Tests, in mice, of a drug developed by the researchers showed that regulatory T cells can be attracted to specific body parts, boosted in number, and activated to suppress immune response and rebuild tissue.

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Treatment Disease Immune Response Clinical Trials 120

Science Daily: Pharmacology News

DECEMBER 12, 2024

Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.

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Immune Response Regulations Therapies Research 87

The Pharma Data

MAY 16, 2021

Adjuvanted recombinant COVID-19 vaccine candidate triggered strong neutralizing antibody responses in all adult age groups. High immune response after a single dose in patients with prior infection shows strong booster potential. For media and investors only. Issued: London UK. About the Phase 2 study. Sanofi, Empowering Life.

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Immune Response Vaccine Trials Treatment 52

Drug Target Review

NOVEMBER 24, 2023

1 Dr Ninh (Irene) La-Beck, from the Department of Immunotherapeutics and Biotechnology at the Texas Tech University Health Sciences Center (TTUHSC) Jerry H. The grant will enable her to investigate the interaction of nanoparticles with the immune system and cancer, supporting the development of new drug delivery systems.

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Immune Response Pharmacy Treatment Virus 111

Broad Institute

OCTOBER 11, 2023

The drugs work by blocking a protein, PD-1 — which helps keep immune responses in check — and stimulating the immune system to attack tumors. The researchers soon partnered with Calico Life Sciences , which in collaboration with AbbVie , discovered drug candidates that block the PTPN2 protein.

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Research Immune Response Clinical Trials Therapies 137

Drug Target Review

DECEMBER 27, 2023

This interaction inhibits inflammation and immune activation, and in particular prevents macrophages from phagocytosing and destroying cancer cells. By blocking CD24 with an antibody drug, our goal is to powerfully reactivate the anti-cancer immune response and drive therapeutic efficacy.

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Immune Response Science Clinical Development Drugs 105

Broad Institute

JULY 11, 2024

Reporting in Science , researchers at Massachusetts General Hospital and the Broad Institute of MIT and Harvard have made a surprising discovery about these drugs. They found that mIDH1 inhibitors trick the tumor cells into thinking they are infected with a virus, causing the immune system to mount an antiviral response.

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Treatment Immune Response Virus Drugs 72

Science Daily: Pharmacology News

DECEMBER 19, 2024

Stitching together four molecules found in the standard flu vaccine ensures an immune response to all of them, scientists have shown.

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Vaccine Immune Response 74

Drug Target Review

APRIL 17, 2024

HLA are the critical molecules that our immune systems use to present peptides to T cells and facilitate recognition and killing in immune responses to pathogens. HLA-II presents peptides to CD4 T cells thought to be important for indirectly helping immune responses and facilitating antibody production.

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Immune Response Laboratories DNA Virus 105

Science Daily: Pharmacology News

OCTOBER 24, 2024

A strain of the bacterium harbored in the children's gut microbial communities possessed a previously unknown gene capable of producing and metabolizing key molecules involved in regulating many important functions ranging from appetite, immune responses, neuronal function, and the ability of pathogenic bacteria to produce disease.

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Immune Response Regulations Disease Research 87

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

By adding synergistic self-adjuvanting properties to Covid-19 RNA vaccines, researchers showed they could significantly boost the immune response generated in mice.

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RNA Vaccine Engineering Immune Response 86

PLOS: DNA Science

FEBRUARY 8, 2024

The molecular tools of CRISPR were borrowed and developed from the natural immune response of bacteria to viruses – bacteriophages – that infect them. DNA Science recently covered perfumes resurrected from extinct plants, but using older and less precise recombinant DNA technology. appeared first on DNA Science.

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Immune Response DNA Engineering Virus 94

Drug Target Review

OCTOBER 19, 2023

Their research centres around a remarkable immune protein called IL-31, which not only induces itching but also plays a crucial role in regulating inflammation. In the absence of IL-31, these nerve cells failed to control the immune system, leading to unchecked inflammation.

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Immune Response Regulations Treatment Therapies 104

Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain. Credit: Neumann EN, Bertozzi TM, et al.

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Disease Therapies Engineering Clinical Trials 142

Science Daily: Pharmacology News

OCTOBER 18, 2023

Immunotherapies, which mobilize the body's immune defenses against a cancer, have not been effective for GBM, in part because the tumor's surrounding environment is largely impenetrable to assaults from the body's immune system.

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Therapies Immune Response Research Virus 76

PerkinElmer

JANUARY 25, 2023

Laboratory professionals in all areas of science have experienced significant changes in recent years, and 2022 was no exception. Experts in the diagnostics and life sciences industry look back on 2022 and lend their insights on the major trends and technologies shaping laboratories in 2023.

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Science Laboratories Immune Response Disease 52

Drug Target Review

MARCH 26, 2024

DGG: Resilience: In science, we can’t predict and control everything. Sometimes science “speaks” and sometimes it doesn’t. Teach them that they can make a difference while nurturing their skills in the sciences and mathematics. As a woman in STEM, what unique perspectives or strengths do you believe you bring to your work?

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Vaccine Virus Immune Response Science 110

Drug Target Review

JANUARY 15, 2024

Researchers from the Nara Institute of Science and Technology (NAIST) have used the reverse-blastocyst complementation (rBC) method to understand the conditions required to form lungs in rat-mouse chimeric models. They also used the tetraploid-based organ complementation (TOC) method to create a rat-derived lung in their mouse model.

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Immune Response Disease Science Therapies 113

Drug Target Review

OCTOBER 16, 2023

This is particularly pertinent in immune-based cell therapies like CAR-T, where animals do not mimic the human immune response. Nikki’s life sciences experience spans leadership, commercial and research roles. About the author Nikki Carter Commercial Organoid Innovation Director, Molecular Devices.

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Disease Immune Response Cell Biology Therapies 122

PLOS: DNA Science

OCTOBER 12, 2023

Can they deliver healing genes without triggering an overactive immune response? The details are disturbingly reminiscent of the famous case of Jesse Gelsinger , who died from a ferocious immune response to experimental gene therapy in September 1999. An immune response is two-tiered.

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Therapies Immune Response DNA Virus 69

Drug Target Review

OCTOBER 4, 2023

More recently, researchers have begun to look at conjugating immunomodulatory agents to antibodies to directly activate an immune response against the tumour. This approach – immune-stimulating antibody conjugates (ISACs) – uses a payload that stimulates the innate and adaptive immune responses, recruiting tumour-fighting T cells.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

Science Daily: Pharmacology News

SEPTEMBER 29, 2023

Now, an article challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice.

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Immune Response Laboratories 75

Science Daily: Pharmacology News

NOVEMBER 20, 2024

The most comprehensive map of the developing human thymus sheds light on how immune responses are built and maintained at early life, with implications for understanding and treating immunodeficiency, autoimmunity, and cancer.

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Immune Response 62

The Pharma Data

JANUARY 31, 2021

–( BUSINESS WIRE )– Gilead Sciences, Inc. While HIV treatment has advanced dramatically over the past three decades, people living with HIV still face a lifetime of therapy,” said Diana Brainard, MD, Senior Vice President, Virology Therapeutic Area, Gilead Sciences. About Gilead Sciences. Gilead Sciences, Inc.

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Science Daily: Pharmacology News

JULY 12, 2023

The finding upends 40 years of conventional wisdom and may offer new insights into cancer, viral infections and immune responses. They hijack a little-known piece of the cell's DNA repair function to close themselves into a ring-like shape and then create a matching double strand.

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DNA Immune Response 71

Drug Target Review

MAY 14, 2024

The combination of P1 with antiPD1 more efficiently activated innate and adaptive immune responses than either P1 or antiPD1 alone by re-energising T cell effector functions, thus providing the remarkable reduction of tumour growth in solid tumours and extended survival period.

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Engineering Immune Response FDA Approval Clinical Trials 59

LifeSciVC

MAY 9, 2024

Take Janux Therapeutics, a biotech focused on developing immunotherapies that generate tumor-specific immune responses to attack and kill tumors without destroying a patient’s healthy tissue. While early, these data demonstrate clear promise to advance this modality.

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Immune Response Vaccine Therapies Engineering 73

LifeSciVC

JULY 1, 2024

One thread that has run throughout it has been my passion for science as a lens for looking at the world. In particular, I love connecting science to daily life. Pfizer’s recent campaign around “ Science Will Win ” similarly appealed to the ethos of the power of science to help humanity. Build your social immunity.

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Science Immune Response Molecular Biology RNA 80

Drug Target Review

APRIL 3, 2024

Making a little tangle of DNA visible to the eye and understanding that this is the basis of complex organisms, which might be altered in disease, was the defining moment for my future path in life sciences. Communication and networking are key in any career, with science being no exception.

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Science Clinical Development Treatment DNA 105

Science Daily: Pharmacology News

JULY 12, 2023

Researchers have demonstrated that a transplant surgical procedure (called 'needle trauma') triggers a profound immune response and causes the death of most grafted dopamine neurons.

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Therapies Immune Response Disease Research 68

Drug Target Review

NOVEMBER 17, 2023

NK cells are among the front line of protection from infected and abnormal cells as part of the ‘innate immune response’. They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells).

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Therapies Cell Biology Clinical Trials Trials 118

PLOS: DNA Science

MAY 16, 2024

These factors are converging to enable both identification of novel infectious diseases as well as microbial resistance, before these threats can impact public health, write a team from the European Society for Clinical Microbiology and Infectious Diseases in Frontiers in Science. appeared first on DNA Science.

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Virus DNA RNA Vaccine 97

Broad Institute

AUGUST 7, 2023

MIT biology PhD student Bingxu Liu and Rebecca Carlson PhD ’23, a recent graduate of the Medical Engineering and Medical Physics program through the Harvard-MIT Division of Health Sciences and Technology, are the lead authors of the paper, which appears in Science. Paper Cited Liu B, Carlson R, et al. Human STING is a proton channel.

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Regulations Clinical Trials Engineering DNA 91

PLOS: DNA Science

OCTOBER 3, 2024

The idea to redirect an immune response against a pathogen to fight cancer goes back to 1891, when Manhattan bone surgeon William Coley became intrigued by a man’s neck tumor that melted away after he contracted a nasty Streptococcus skin infection. Because research is very active in this field, William B.

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Vaccine Immune Response DNA Treatment 52

Drug Target Review

OCTOBER 26, 2023

9 In addition, host immune responses further add to the complexity of developing cell-specific AAV capsids for clinical applications. It has been well established that exposure to wild-type AAV results in priming of the immune system against the virus.

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Engineering Virus Therapies Immune Response 105

The Pharma Data

AUGUST 27, 2020

SCIENCE PHOTO LIBRARY. A new effort is under way to understand how the immune system responds to coronavirus. Scientists from 17 UK research centres are attempting to answer questions such as how long immunity lasts and why disease severity varies so much. Image copyright. It has received £6.5m More severe cases.

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Immune Response Virus Vaccine Disease 52