Information - Drug Discovery Digest

Introducing DrugChatter: Revolutionizing Information Access

Drug Patent Watch

JUNE 25, 2024

DrugChatter is an innovative AI-powered search and answer engine designed to revolutionize how we access and comprehend information. What Makes DrugChatter Unique?

Engineering

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Science Daily: Pharmacology News

OCTOBER 17, 2024

A new study opens the door to cutting-edge solutions that could contribute to the realization of a system capable of processing quantum information in a simple yet powerful way. This control makes it possible to improve the detection and number of photon coincidences, as well as the efficiency of the system.

Research

Martian meteorites deliver a trove of information on Red Planet's structure

Science Daily: Pharmacology News

MAY 31, 2024

These results are important for understanding not only how Mars formed and evolved, but also for providing precise data that can inform recent NASA missions like Insight and Perseverance and the Mars Sample Return.

Fossil of huge terror bird offers new information about wildlife in South America 12 million years ago

Science Daily: Pharmacology News

NOVEMBER 4, 2024

Evolutionary biologists report they have analyzed a fossil of an extinct giant meat-eating bird -- which they say could be the largest known member of its kind -- providing new information about animal life in northern South America millions of years ago.

PreSTAR: a New Template for Pre Submissions and 513(g) Requests for Information

FDA Law Blog: Biosimilars

JUNE 26, 2024

Lenz, Principal Medical Device Regulation Expert — FDA recently released a new eSTAR template for device pre-submissions and 513(g) Requests for Information, referred to as PreSTAR. A 513(g) Request for Information is a means of obtaining FDA’s views about the classification and regulatory requirements for a particular device.

FDA

FDA Regulations Production Packaging

How the Proper Product Information Management (PIM) System Can Boost Sales During the Holiday Season

Perficient: Drug Development

AUGUST 29, 2024

To properly capitalize on this opportunity, companies must ensure their product information is accurate, consistent, and compelling across all channels. This is where Product Information Management (PIM) systems come into play. PIM systems ensure that product information is consistent and up to date across all channels.

Production

Production Engineering Marketing

Are You Using Next-Gen Sequencing to inform AAV product and process quality? Here are 4 reasons you should

BioPharma Drive: Drug Pricing

DECEMBER 2, 2024

Next-generation sequencing allows for critical insights into gene therapy products, which can help streamline and accelerate everything from process development and production to regulatory approval.

Production

Production Therapies

GDC-6599

Drug Hunter

SEPTEMBER 18, 2023

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples. GDC-6599 offers a notable case study in addressing several unexpected toxicities while pursuing a novel target through mechanistic investigation. Get ahead now by requesting a trial. already a member?

Trials

Trials Drugs

Lessons from Monte Carlo Models: Why Drug Development is Hard

DrugBaron

FEBRUARY 16, 2024

What this taught us that returns are most sensitive to costs, particularly during the early iterations (such that it rarely makes sense to pay extra for more information, even if it modestly improves the quality of the decision filter). In short, assumptions that describe the early-stage investing world pretty well.

Drug Development

Drug Development Pharma Companies Drugs Science

More LRRK2 On-Target Toxicity?

Drug Hunter

AUGUST 15, 2023

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples. Initial Detection of A Distinct Toxicity Related to LRRK2 Inhibition request a trial You don’t have time to read everything, but you can’t afford to fall behind. Get ahead now by requesting a trial.

Small Molecule

Small Molecule Trials Treatment Disease

Cracking the code of life: new AI model learns DNA's hidden language

Science Daily: Pharmacology News

AUGUST 5, 2024

With GROVER, a new large language model trained on human DNA, researchers could now attempt to decode the complex information hidden in our genome. GROVER treats human DNA as a text, learning its rules and context to draw functional information about the DNA sequences.

DNA

DNA Research

Workings of working memory detailed

Science Daily: Pharmacology News

APRIL 17, 2024

Investigators have discovered how brain cells responsible for working memory--the type required to remember a phone number long enough to dial it--coordinate intentional focus and short-term storage of information.

Method identified to double computer processing speeds

Science Daily: Pharmacology News

FEBRUARY 21, 2024

This system doubles computer processing speeds with existing hardware by simultaneously using graphics processing units (GPUs), hardware accelerators for artificial intelligence (AI) and machine learning (ML), or digital signal processing units to process information.

Studies uncover the critical role of sleep in the formation of memories

Science Daily: Pharmacology News

JUNE 13, 2024

A lack of sleep can make it extraordinarily difficult to retain information. Two new studies uncover why this is and what is happening inside the brain during sleep and sleep deprivation to help or harm the formation of memories.

A simple quantum internet with significant possibilities

Science Daily: Pharmacology News

MAY 15, 2024

It's one thing to dream up a quantum internet that could send hacker-proof information around the world via photons superimposed in different quantum states. It's quite another to physically show it's possible.

Cells may possess hidden communication system

Science Daily: Pharmacology News

APRIL 24, 2024

A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function.

Research

Molecules on the Move: April ’23

Drug Hunter

MAY 31, 2023

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples. I/II Data request a trial You don’t have time to read everything, but you can’t afford to fall behind. Get ahead now by requesting a trial. already a member?

Small Molecule

Small Molecule Clinical Trials Trials Drugs

Scientists unveil complete cell map of a whole mammalian brain

Science Daily: Pharmacology News

DECEMBER 13, 2023

This atlas serves as a map for the mouse brain, describing the type, location, and molecular information of more than 32 million cells and providing information on connectivity between these cells. Researchers have created a complete cell atlas of a whole mammalian brain.

Research

Breakthrough in molecular control: New bioinspired double helix with switchable chirality

Science Daily: Pharmacology News

AUGUST 8, 2024

In a new study, researchers have developed novel double-helical monometallofoldamers that exhibit controllable helicity inversion and chiral information transfer, in response to external stimuli.

Research

Scientists use generative AI to answer complex questions in physics

Science Daily: Pharmacology News

MAY 16, 2024

Researchers used generative AI to develop a physics-informed technique to classify phase transitions in materials or physical systems that is much more efficient than existing machine-learning approaches.

Research

CDD Vault Update (September 2024)

Collaborative Drug

SEPTEMBER 11, 2024

Chemical Safety Information: When working in a lab, you must understand the risks associated with handling chemicals. CDD Vault now displays safety information obtained from PubChem as a helpful reminder. If available, you will find hazard pictograms next to the name at the top of the molecule page.

Study explains why the brain can robustly recognize images, even without color

Science Daily: Pharmacology News

MAY 23, 2024

The researchers found evidence that early in life, when the retina is unable to process color information, the brain learns to distinguish objects based on luminance, rather than color. New research offers a possible explanation for how the brain learns to identify both color and black-and-white images.

Research

Cells of the future: A key to reprogramming cell identities

Science Daily: Pharmacology News

DECEMBER 20, 2023

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time.

DNA

Surprising behavior in one of the least studied mammals in the world

Science Daily: Pharmacology News

FEBRUARY 9, 2024

Now, a new study reveals surprising information about the Baird's beaked whale species. Beaked whales are among the least studied mammals in the world.

Alaska dinosaur tracks reveal a lush, wet environment

Science Daily: Pharmacology News

MARCH 12, 2024

A large find of dinosaur tracks and fossilized plants and tree stumps in far northwestern Alaska provides new information about the climate and movement of animals near the time when they began traveling between the Asian and North American continents roughly 100 million years ago.

Athletes have significantly better working memory than sedentary people

Science Daily: Pharmacology News

NOVEMBER 20, 2024

A recently published meta-analysis reveals an advantage in sports-related information processing compared to non-athletes. The data consisted of 21 studies involving a total of 1455 participants. Athletes had better working memory than non-athletes and this advantage was further enhanced when athletes were compared to sedentary people.

Boost Alphafold2 Protein Structure Prediction with GPU-Accelerated MMseqs2

Nvidia Developer: Drug Discovery

NOVEMBER 13, 2024

This is often done in the form of a multiple sequence alignment (MSA), and the evolutionary information retrieved from these alignments can yield insights into protein structure, function, and evolutionary history. The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers.

Science

Science Research Drugs

How the brain is flexible enough for a complex world (without being thrown into chaos)

Science Daily: Pharmacology News

MAY 10, 2024

Mechanisms such as oscillations and neuromodulators recruit their participation and tune them to focus on the relevant information. Many neurons exhibit 'mixed selectivity,' meaning they can integrate multiple inputs and participate in multiple computations.

Gravitational waves unveil previously unseen properties of neutron stars

Science Daily: Pharmacology News

SEPTEMBER 5, 2024

A new study details how new insights into how dissipative tidal forces within double -- or binary -- neutron star systems will inform our understanding of the universe.

Nature and plastics inspire breakthrough in soft sustainable materials

Science Daily: Pharmacology News

OCTOBER 9, 2024

Using peptides and a snippet of the large molecules in plastics, materials scientists have developed materials made of tiny, flexible nano-sized ribbons that can be charged just like a battery to store energy or record digital information.

What makes a memory? It may be related to how hard your brain had to work

Science Daily: Pharmacology News

MAY 13, 2024

Why do some of the experiences in this deluge of sensory information become 'memorable,' while most are discarded by the brain? The human brain filters through a flood of experiences to create specific memories.

Storm in a laser beam: Physicists create 'light hurricanes' that could transport huge amounts of data

Science Daily: Pharmacology News

NOVEMBER 11, 2024

The discovery, centred around controlling tiny hurricanes of light and electromagnetic fields, could revolutionise how much information we can deliver over cables.

More plants on the menu of ancient hunter-gatherers

Science Daily: Pharmacology News

APRIL 29, 2024

However, due to the scarcity of well-preserved human remains from Paleolithic sites, little information exists about the dietary habits of pre-agricultural human groups. It has long been thought that meat played an important role in the diet of hunter-gatherers before the Neolithic transition.

New technique helps AI tell when humans are lying

Science Daily: Pharmacology News

MARCH 18, 2024

Researchers have developed a new training tool to help artificial intelligence (AI) programs better account for the fact that humans don't always tell the truth when providing personal information.

Research

Climate change threatens Antarctic meteorites

Science Daily: Pharmacology News

APRIL 8, 2024

Antarctica harbors a large concentration of meteorites imbuing the icy continent with an unparalleled wealth of information on our solar system. However, these precious meteorites are rapidly disappearing from the ice sheet surface due to global warming, according to a new study.

Quantum researchers cause controlled 'wobble' in the nucleus of a single atom

Science Daily: Pharmacology News

SEPTEMBER 12, 2024

The research offers prospects for storing quantum information inside the nucleus, where it is safe from external disturbances. They caused the atomic nucleus to interact with one of the electrons in the outermost shells of the atom. This electron could be manipulated and read out through the needle of a scanning tunneling microscope.

Research

Autobiographical memory in the digital age: Our lives in the mirror of our data

Science Daily: Pharmacology News

OCTOBER 7, 2024

Never before have people recorded more information about their lives than today. But what does this mean for the way we remember our lives and how we talk about them? Researchers are trying to find answers to these questions.

Research

Compact error correction: Towards a more efficient quantum 'hard drive'

Science Daily: Pharmacology News

NOVEMBER 11, 2024

Two quantum information theorists have solved a decades-old problem that will free up quantum computing power.

Mysteries of icy ocean worlds

Science Daily: Pharmacology News

DECEMBER 20, 2024

A study introduces a novel thermodynamic concept called the 'centotectic' and investigates the stability of liquids in extreme conditions -- critical information for determining the habitability of icy moons like Europa.

'Wraparound' implants represent new approach to treating spinal cord injuries

Science Daily: Pharmacology News

MAY 8, 2024

Unlike current approaches, the new devices can record 360-degree information, giving a complete picture of spinal cord activity. A team of engineers, neuroscientists and surgeons developed the devices and used them to record the nerve signals going back and forth between the brain and the spinal cord.

Engineering

Engineering Treatment

ChEMBL brings drug bioactivity data to the Protein Data Bank in Europe

The ChEMBL-og

OCTOBER 23, 2024

But here's the catch: while ChEMBL provides extensive information on a molecule's activity and cross references to other data sources, it doesn't always tell us if a 3D structure is available for a specific drug-target complex. This can be a roadblock for researchers who need that structural information to design effective drugs.

Small Molecule

Small Molecule Drugs Research Science

Study sheds light on the origin of the genetic code

Science Daily: Pharmacology News

DECEMBER 12, 2024

Nearly all living organisms use the same genetic code, a complicated mechanism by which genetic information is translated into proteins, the building blocks of life. A new study suggests conventional wisdom about how the code evolved is likely flawed.

Genetic risk prediction for 10 chronic diseases moves closer to the clinic

Broad Institute

FEBRUARY 19, 2024

Over the past decade, scientists have developed these risk scores for dozens of diseases, including heart disease, kidney disease, diabetes, and cancer, with the hope that patients could one day use this information to lower any heightened risk of disease. What’s the score?

Disease

Disease Clinical Research Research Treatment

Top 10 climate science insights unveiled

Science Daily: Pharmacology News

DECEMBER 5, 2023

A new report equips policymakers with the latest and most pivotal climate science research from the previous 18 months, synthesized to help inform negotiations at COP28 and policy implementation through 2024 and beyond.

Science

Science Research

Introducing DrugChatter: Revolutionizing Information Access

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Trending Sources

Martian meteorites deliver a trove of information on Red Planet's structure

Fossil of huge terror bird offers new information about wildlife in South America 12 million years ago

PreSTAR: a New Template for Pre Submissions and 513(g) Requests for Information

How the Proper Product Information Management (PIM) System Can Boost Sales During the Holiday Season

Are You Using Next-Gen Sequencing to inform AAV product and process quality? Here are 4 reasons you should

GDC-6599

Lessons from Monte Carlo Models: Why Drug Development is Hard

More LRRK2 On-Target Toxicity?

Cracking the code of life: new AI model learns DNA's hidden language

Workings of working memory detailed

Method identified to double computer processing speeds

Studies uncover the critical role of sleep in the formation of memories

A simple quantum internet with significant possibilities

Cells may possess hidden communication system

Molecules on the Move: April ’23

Scientists unveil complete cell map of a whole mammalian brain

Breakthrough in molecular control: New bioinspired double helix with switchable chirality

Scientists use generative AI to answer complex questions in physics

CDD Vault Update (September 2024)

Study explains why the brain can robustly recognize images, even without color

Cells of the future: A key to reprogramming cell identities

Surprising behavior in one of the least studied mammals in the world

Alaska dinosaur tracks reveal a lush, wet environment

Athletes have significantly better working memory than sedentary people

Boost Alphafold2 Protein Structure Prediction with GPU-Accelerated MMseqs2

How the brain is flexible enough for a complex world (without being thrown into chaos)

Gravitational waves unveil previously unseen properties of neutron stars

Nature and plastics inspire breakthrough in soft sustainable materials

What makes a memory? It may be related to how hard your brain had to work

Storm in a laser beam: Physicists create 'light hurricanes' that could transport huge amounts of data

More plants on the menu of ancient hunter-gatherers

New technique helps AI tell when humans are lying

Climate change threatens Antarctic meteorites

Quantum researchers cause controlled 'wobble' in the nucleus of a single atom

Autobiographical memory in the digital age: Our lives in the mirror of our data

Compact error correction: Towards a more efficient quantum 'hard drive'

Mysteries of icy ocean worlds

'Wraparound' implants represent new approach to treating spinal cord injuries

ChEMBL brings drug bioactivity data to the Protein Data Bank in Europe

Study sheds light on the origin of the genetic code

Genetic risk prediction for 10 chronic diseases moves closer to the clinic

Top 10 climate science insights unveiled

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