article thumbnail

How the AI revolution can accelerate early drug discovery

Drug Target Review

Complex challenges such as metabolic stability or absorption, distribution, metabolism or excretion (ADME) properties could be better predicted, accurately filtering out poor candidates and streamlining discovery. To really benefit from AI, the pharmaceutical industry must be more open to data sharing.

Drugs 105
article thumbnail

Obstacles and innovations of macrocyclic drug development

Drug Target Review

Researchers have shown that cell permeability can be improved by designing macrocyclic peptides whose structure includes amide (NH) groups that are engaged in internal hydrogen bonding interactions. Cyclic Peptide Design, Chapter 2: Strategies to Enhance Metabolic Stabilities. Pharmaceuticals , 16(7):996, 2023. Springer, 2019.