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But as molecularbiology has advanced, so too has our approach to finding new drugs. Another promising avenue is the use of technologies like RNA interference and gene editing, which allow scientists to turn off the production of certain proteins altogether. This method was more about serendipity than science.
By identifying proteins that only interact with each other in cancer, but not normal tissues, we can really expand the repertoire of ADC therapeutics beyond monoclonal antibodies developed based solely on RNA expression profiles. His work has been published in many high-impact journals and presented at international oncology meetings.
.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecularbiology and biophysics. How do transcription factors couple up with the correct RNA molecule?
.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecularbiology and biophysics. How do transcription factors couple up with the correct RNA molecule?
But the technologies devised in the process of trying may revolutionize other areas of science, especially reproductive biology. Biology is a Burrito. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. 15 of 31. Nature 28 of 31.
A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecularbiology history.
A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecularbiology history.
From her first biology course in high school, Rehm loved the logic of genetics: the clear trajectory from a simple code of DNA to RNA to proteins and how disrupting that process could lead to disease. That wouldnt happen without consistent variant interpretation.
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