Drug Discovery World

NOVEMBER 3, 2023

New UK therapy option for hard-to-treat lymphoma The MHRA has granted conditional marketing authorisation for Abbvie’s Tepkinly (epcoritamab) as a bispecific treatment for adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy.

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Chemical Biology and Drug Design

JANUARY 15, 2024

The expression levels of endoplasmic reticulum (ER) stress-related protein and silent information regulator 1/nuclear factor kappa-B (Sirt1/NF-κB) signaling pathway were used to observe the therapeutic effect of naringin. Cardiac tissue damage and fibrosis caused by 20 Gy XR were significant improved after NG treatment.

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Drug Discovery World

OCTOBER 24, 2023

MP : We currently develop CRISPR based molecular tools for clients creating new therapies for the treatment of various diseases, but we also work in diagnostics and agriculture. As an example, we work with Spanish company Integra Therapeutics, combining their technology with ours to develop a therapeutic treatment approach.

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Drug Discovery World

JANUARY 11, 2024

Patients affected by the disease are found to also experience an imbalance of glutathione regulation, which is important for liver detoxification. Successful industry/academia collaboration Fewer than 5% of rare diseases have approved therapies and most of these treatments use gene therapy.

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Drug Discovery World

JULY 30, 2024

Their findings, published in Annals of Internal Medicine , have raised interest about the drug’s potential benefit for tobacco use disorders (TUDs). The authors have called for clinical trials to evaluate semaglutide’s potential as a TUD treatment.

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Drug Discovery World

NOVEMBER 14, 2023

A very rare, inherited blood clotting disorder, cTTP is caused by a disease-causing mutation in the ADAMTS13 gene, which is responsible for making an enzyme, also named ADAMTS13, that regulates blood clotting. Without treatment, cTTP is ultimately fatal.

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Agency IQ

MARCH 1, 2024

What we expect European regulators to do in March 2024 In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

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Drug Discovery World

AUGUST 28, 2024

JT: We are developing novel small molecule, disease-modifying, allosteric regulators to treat serious diseases such as Parkinson’s disease and other dementias. Gain’s lead drug candidate GT-02287 is a best-in-class small molecule for the treatment of GBA-Parkinson’s disease and other neurodegenerative diseases.

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Drug Discovery World

JANUARY 10, 2024

In alignment with the FDA’s stance, we maintain that the benefits of CAR-T therapies still outweigh the potential risks in the majority of cases. “Risks from CAR-T cell therapy should be contextualised against other standard treatment modalities such as chemotherapy and radiotherapy.

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Drug Discovery World

MARCH 31, 2023

News round-up for 27-31 March by DDW Digital Content Editor Diana Spencer. As March draws to a close, this week’s key announcements have demonstrated the breadth of international approaches to tackling cancer, with vaccines, proenzymes, immunotherapies and antibody-based treatments all currently under investigation around the world.

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The Pharma Data

NOVEMBER 18, 2020

The topic of sanitation regulation is also covered in ‘ Catalysing Citywide Sanitation For All Through Regulating Service Providers ‘ by IWA’s Regulation for Citywide Inclusive Sanitation initiative’s advisory and taskforce members – Yvonne Magawa (ESAWAS), Diego Polania (CRA), and Gustavo Saltiel (World Bank).

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Drug Discovery World

JANUARY 23, 2023

This action sensitised GBM cells to radiotherapy both in vitro and in vivo (in mouse models). “Our research has revealed cladribine as a radiosensitiser for GBM treatment by drug repurposing, which can offer multiple advantages,” says Prof Youn. “As

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Agency IQ

DECEMBER 1, 2023

What we expect European regulators to do in December 2023 In this new recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

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Agency IQ

OCTOBER 27, 2023

What we expect European regulators to do in November 2023 In this new recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

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Drug Discovery World

JUNE 15, 2023

The International Society for Cellular Therapy (ISCT) is a global society of clinicians, regulators, technologists, and industry partners with a shared mission to drive the translation of all cell and gene (CGT) therapies for the benefit of patients worldwide. Regulation is necessary, but optimising timescales would be ideal.

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Drug Discovery World

JUNE 22, 2023

Although immune checkpoint inhibitors have already made an impact in cancer treatment, most patients either fail to achieve a response or experience relapse. The Nature publication reveals the previously unrecognised role of the RGMb molecule in regulating the body’s response against cancer cells.

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H1 Blog

SEPTEMBER 26, 2023

Breaking Down Barriers to International Clinical Trials Global Disruptions, Health Equity & Data Sharing As the U.S. Breaking Down Barriers to International Clinical Trials Global Disruptions, Health Equity & Data Sharing As the U.S. It comes just a day after the U.S. First let’s look at some challenges and then opportunities.

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Drug Discovery World

JUNE 19, 2024

JT: Cancer is an incredibly complex and heterogeneous disease, and, devastatingly, around 10 million people worldwide lose their lives to it every year 1. Despite the progress made in care, there remains a significant gap in treatment options for people with rare cancers and those that are resistant to standard therapies.

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Drug Target Review

JANUARY 30, 2024

This kind of regulation in AC activity is a kind of cellular adaptation in to the activation of opioid receptors and contributes to the development of opioid tolerance, dependence, and withdrawal 5. To facilitate MOR to transform to such a conformation is one of the strategies to induce MOR endocytosis. Br J Pharmacol. 2012;165(6):1704-16.

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Conversations in Drug Development Trends

AUGUST 9, 2024

It broadens recruitment strategies, diversifies the patient population, and expands the study population, thus increasing access to potentially life-saving treatments. These trials increase the chances of success by enabling the early detection of effective treatments in defined populations and focusing efforts on the most promising options.

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Drug Discovery World

AUGUST 3, 2023

Medical cannabis is often a first-thought when regarding plant-based medicines, but there remains public scepticism, arguably due to the regulations relating to the substance. For example, the FDA has not approved a marketing application for cannabis for the treatment of any disease or condition to date 1.

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The Pharma Data

FEBRUARY 24, 2022

Today’s approval will provide a treatment option for a wider range of patients with heart failure,” said Norman Stockbridge, M.D., Despite therapies in multiple drug classes, mortality remains high and treatment options for a broader range of patients are needed. Source link: [link].

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Drug Discovery World

JULY 5, 2023

Precision oncology supports targeted therapeutic treatments by determining the specific molecular characteristics of a tumour – the molecular phenotype, as it’s called – to obtain an in depth understanding of the patient’s unique cancer and using it to specifically target the patient’s cancer on a molecular level.

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The Pharma Data

MAY 27, 2022

The FDA’s decision is informed by the results of Pfizer’s nonclinical studies and a Phase 2a clinical study of ervogastat/clesacostat, which showed that treatment with ervogastat/clesacostat reduced liver fat with a favorable safety and tolerability profile. Pfizer Inc. NYSE: PFE) today announced the U.S.

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Drug Discovery World

JUNE 16, 2023

The International Society for Cellular Therapy (ISCT) is a global society of clinicians, regulators, technologists, and industry partners with a shared mission to drive the translation of all cell and gene (CGT) therapies for the benefit of patients worldwide. DDW’s Megan Thomas heard from attendees about key trends in the sector.

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Drug Target Review

MARCH 19, 2024

In the current study undertaken by an international team of researchers, co-led by Dr William Reay, we used the genetics of retinol itself as a way to proxy its effect in thousands of traits, including brain structure, vision, and the immune system through causal modelling.

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Drug Discovery World

OCTOBER 19, 2022

There are clearly ethical issues associated with suddenly discontinuing treatment and wider medicine availability at a time of crisis, and it’s clear that trial sponsors and personnel have worked hard to maintain a high level of activity despite supply chain and security challenges. . The role of the international community .

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Drug Discovery World

DECEMBER 6, 2022

To explore the analytics further, MPE conducted a literature review exploring the barriers and facilitators to clinical trial access in Europe, alongside qualitative interviews with haematologists, researchers and regulators in three selected CEE countries (Poland, Croatia and Macedonia). Key findings include: .

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The Pharma Data

JANUARY 18, 2021

Food and Drug Administration (FDA) has granted the Company a Breakthrough Device designation for its first-in-class, implantable Atrial Flow Regulator (AFR) for heart failure (HF) patients with preserved (HFpEF) or reduced (HFrEF) ejection fraction. SOURCE Occlutech International. SCHAFFHAUSEN, Switzerland , Jan. Source link.

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The Pharma Data

NOVEMBER 27, 2020

FDA Approves Danyelza (naxitamab-gqgk) for the Treatment of Neuroblastoma. the “Company” or “Y-mAbs”) (Nasdaq: YMAB) a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, antibody-based therapeutic products for the treatment of cancer, today announced that the U.S. NEW YORK, Nov.

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Drug Discovery World

APRIL 20, 2023

There is a clear opportunity to repurpose some of these candidates for preventative/ prophylactic treatment for post-Covid-19 cognitive impairment. These may provide an opportunity for treatment for post-Covid-19 cognitive impairment. New therapeutics of course depend on an understanding of biological mechanisms. depression).

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Drug Discovery World

JUNE 12, 2023

The International Society for Cellular Therapy (ISCT) is a global society of clinicians, regulators, technologists, and industry partners with a shared mission to drive the translation of all cell and gene therapies for the benefit of patients worldwide. DDW’s Megan Thomas heard from attendees about key trends in the sector.

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Drug Discovery World

MARCH 2, 2023

DDW’s Diana Spencer reports on the recent Avacta Therapeutics Science Day, which explored the latest exciting developments in targeted treatments for cancer and asked what advances the future might bring. She explained the mechanism by which AVA6000 can provide more precise treatment than current chemotherapies.

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Drug Target Review

MARCH 4, 2024

This distinction in stem cell regulation may explain the features of colon cancers in the two regions of the colon, and therefore lead to new combinations of existing therapies to improve treatment efficacy. However, the loss of CDX2 produced notable differences in regulation of the genes controlling stem cell differentiation.

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Drug Discovery World

MARCH 16, 2023

With a maturing clinical pipeline, many FDA-approved treatments are on the horizon. Regulators, developers, and manufacturers must work together to establish appropriate guidelines, which requires collaboration across all elements of the value chain. The post Can characterisation industrialise cell and gene therapy?

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Agency IQ

AUGUST 2, 2024

What We Expect the FDA to do in August and September 2024 In this ongoing feature, AgencyIQ looks at public data to determine what the FDA is likely to do in the months ahead, including key deadlines, meetings, events, planned regulations, comment periods and more.

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Drug Discovery World

MAY 17, 2024

Predicting treatment outcomes with AI & tumour genetics in oncology trials In a study 8 conducted by the University of California San Diego School of Medicine, researchers used artificial intelligence to overcome a significant hurdle in oncology: predicting chemotherapy resistance. So, what does this mean for clinical trials in oncology?

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