SCIENMAG: Medicine & Health

MARCH 26, 2024

Credit: Redox Medicine […]

Small Molecule 78

Small Molecule International Drug Development Drugs 78

Drug Discovery World

MARCH 27, 2024

Delivery of synthesis targets within small molecule drug discovery often involves many chemists and other collaborators, both internal and external, across multiple locations. Join DDW and Cresset for this free event ‘ Enhancing collaboration in drug discovery – a biotech perspective ’.

Small Molecule 130

Small Molecule Drugs International Production 130

Drug Discovery World

MARCH 21, 2024

Delivery of synthesis targets within small molecule drug discovery often involves many chemists and other collaborators, both internal and external, across multiple locations. Join DDW and Cresset for this free event ‘ Enhancing collaboration in drug discovery – a biotech perspective ’.

Small Molecule 130

Small Molecule Drugs International Production 130

Drug Discovery World

MARCH 14, 2024

Delivery of synthesis targets within small molecule drug discovery often involves many chemists and other collaborators, both internal and external, across multiple locations. Join DDW and Cresset for this free event ‘ Enhancing collaboration in drug discovery – a biotech perspective ’.

Small Molecule 130

Small Molecule International Production Drugs 130

Drug Discovery World

MARCH 7, 2024

Delivery of synthesis targets within small molecule drug discovery often involves many chemists and other collaborators, both internal and external, across multiple locations. Join DDW and Cresset for this free event ‘ Enhancing collaboration in drug discovery – a biotech perspective ’.

Small Molecule 130

Small Molecule International Production Drugs 130

Drug Discovery World

FEBRUARY 29, 2024

Delivery of synthesis targets within small molecule drug discovery often involves many chemists and other collaborators, both internal and external, across multiple locations. Join DDW and Cresset for this free event ‘ Enhancing collaboration in drug discovery – a biotech perspective ’.

Small Molecule 130

Small Molecule Drugs International Production 130

Drug Discovery World

SEPTEMBER 29, 2022

Many companies have several projects ongoing simultaneously, which can limit internal resources (space, lab equipment, personnel) and delay progress. In asking these questions consider that internal resources may also have other commitments that delay progress. protein-protein or small molecule-target interactions).

Small Molecule 130

Small Molecule Assay Development DNA Biochemical Assays 130

Drug Discovery World

FEBRUARY 22, 2024

With no in-house laboratory space, the company works closely with multiple international contract research organisations (CROs), including Axxam, which carry out all of the Libra R&D, from compound screening assays, to in vivo pharmacokinetic/pharmacodynamic and ADME work, as well as in vitro and in vivo pre-clinical safety assessments.

Clinical Trials 130

Clinical Trials Trials Small Molecule Compound Screening 130

Drug Discovery World

FEBRUARY 13, 2024

AM1476 is a selective peripheral-acting 5-HT2B receptor small molecule antagonist that can be delivered orally. Systemic sclerosis is a chronic, progressive, autoimmune disease characterised by inflammation and fibrosis, such as uncontrolled scar tissue formation, in skin and various internal organs.

Disease 130

Disease Treatment Small Molecule Pharmacokinetics 130

DrugBank

MAY 15, 2024

One approach is to look beyond the traditional drug molecule. Researchers are experimenting with biologics—larger biological molecules that can do things small molecules can't, like targeting larger, more complex structures on cell surfaces or even inside cells.

Small Molecule 83

Small Molecule Molecular Biology Drugs Disease 83

The Pharma Data

NOVEMBER 19, 2020

Program has advanced rapidly under an international collaboration of companies led by Sosei Heptares as part of its commitment to socially responsible investing. Sosei Heptares has successfully designed three distinct series of compounds with attractive anti-viral drug-like properties and advanced the most promising molecules.

Small Molecule 40

Small Molecule Structure Based Drug Design (SBDD) Molecular Biology International 40

Drug Discovery World

OCTOBER 4, 2023

An international research effort is underway into how cancer patients develop resistance to drugs and to find suitable targets for intervention, but so far success had been limited. “For example, almost half of patients with lung cancer die from the disease due to tumour regrowth.

Small Molecule 130

Small Molecule Drug Development International Research 130

Drug Discovery World

JUNE 1, 2023

AP-325 is a small molecule drug candidate that binds and modulates the GABAA receptor, reducing the excitability of the respective neurons. Based on the positive DMC review and confirmed financial commitment from its investors, the company will expand the trial to Belgium, France, and Italy.

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Trials Small Molecule Drugs Pharmaceuticals 130

Drug Discovery World

AUGUST 2, 2023

For instance, protein palmitoylation involves the covalent attachment of fatty acyl chains, typically a palmitate to internal cysteine residues of a protein via labile thioester linkages. Ezurpimtrostat (GNS561) was identified from a large library of small molecules as a lead compound for drug development.

Small Molecule 130

Small Molecule Immune Response Clinical Trials International 130

Covalent Modifiers

SEPTEMBER 9, 2023

3c00297 Falling in between traditional small molecules and antibodies in size, peptides are emerging as a privileged therapeutic modality, one that can harness the benefits of both small molecule and antibody drugs. Mengmeng Zheng and Jianmin Gao ACS Chemical Biology 2023 DOI: 10.1021/acschembio.3c00297

Small Molecule 70

Small Molecule International Drugs 70

Covalent Modifiers

JANUARY 13, 2024

Thomas Kodadek Angewandte Chemie International Edition 2024 e202316726 [link] Many of the highest priority targets in a wide range of disease states are difficult-to-drug proteins.

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Small Molecule International Disease Drugs 70

The Pharma Data

NOVEMBER 30, 2020

Biohaven acquires exclusive global rights to a portfolio of novel, small-molecule CGRP antagonists. Mark Swallow , David Dible – International Media +44 (0)20 7638 9571 | SoseiHeptares@citigatedewerogerson.com. TOKYO and CAMBRIDGE, England , Dec. Vlad Coric , M.D., GPCR – G protein-coupled receptors.

Small Molecule 40

Small Molecule Licensing Licensing Clinical Trials 40

Drug Discovery World

MAY 11, 2023

The Phase II trial is part of a new agreement between US-based pharmaceutical company Algok Bio and BTG International, which partnered with the ICR earlier in the drug’s development. Cancer Research UK also helped to fund earlier research.

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Trials Small Molecule Drugs Pharmaceutical Companies 130

Drug Discovery World

OCTOBER 21, 2022

Enanta Pharmaceuticals, a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, has dosed the first subject in its Phase I clinical trial of EDP-323, a novel, oral L-protein inhibitor in development for the treatment of respiratory syncytial virus (RSV). .

Small Molecule 130

Small Molecule Virus Drugs Clinical Trials 130

Drug Discovery World

DECEMBER 7, 2022

Small molecules can face big challenges . Despite the emergence of, and excitement around, advanced therapeutic modalities, traditional small molecule pharmaceuticals still occupy a significant and steadily growing share of the market. By Dr Natalia Dadivanyan , Segment Marketing Manager, Malvern Panalytical .

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Small Molecule Pharmaceuticals Pharmaceutical Companies Drug Development 130

Drug Target Review

JULY 6, 2023

1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. 1 The concept of TPD was first demonstrated with a heterobifunctional small molecule to degrader a protein of interest in the early 2000s.

Targeted Protein Degradation 98

Targeted Protein Degradation Small Molecule Clinical Trials Science 98

The Pharma Data

JANUARY 19, 2021

As part of Aptorum Group’s Acticule infectious disease platform, ALS-4 is a novel orally administered first-in-class small molecule that was developed based on an anti-virulence approach targeting Staphylococcus aureus including MRSA. About ALS-4.

Small Molecule 52

Small Molecule Clinical Trials Trials Pharmacokinetics 52

The Pharma Data

DECEMBER 20, 2020

ALS-4 is a novel small molecule adopting an anti-virulence (non-antibiotic) approach to address the growing unmet medical needs of infections caused by Staphylococcus aureus. The secondary objective is to assess the pharmacokinetic profile of SAD and MAD of ALS-4 administered orally to healthy subjects. About ALS-4.

Small Molecule 40

Small Molecule Clinical Trials Trials Treatment 40

Drug Discovery World

JUNE 6, 2023

However, what he found particularly interesting at the meeting is the emergence of more small molecule immune oncology agents that are actually starting to look as though they might work. He is also a professor of medicine and immunology at the University of Washington School of Medicine.

Small Molecule 130

Small Molecule DNA RNA Research 130

Drug Discovery World

APRIL 29, 2024

Jean-Baptiste Agnus, Chief Business Officer, and Peter Carbone, Chief Quality Officer, KBI Biopharma: Agnus brings more than two decades of experience in the biopharmaceutical industry with expertise in biologics, small molecule APIs, antibody-drug conjugates (ADCs), and cell and gene therapies.

Drugs 130

Drugs Small Molecule Bioinformatics Pharmaceuticals 130

Conversations in Drug Development Trends

APRIL 4, 2024

To help integrate these various regulatory standards, the International Council for Harmonization (ICH) of Technical Requirements for Pharmaceuticals for Human Use was founded in 2016. However, with varying national regulatory agencies each requiring their own unique specifications, this process can be remarkably perplexing.

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Small Molecule Clinical Trials Pharmaceuticals Compliance 80

Drug Discovery World

DECEMBER 26, 2023

Anagenex and Nimbus Therapeutics Anagenex and Nimbus Therapeutics have initiated a research collaboration to discover small molecule drugs for multiple challenging targets. Peter Tummino, Nimbus’ Chief Scientific Officer, said: “At Nimbus, we have prioritised important but difficult-to-drug targets across multiple therapy areas.

Small Molecule 130

Small Molecule Drugs Molecular Biology Bioinformatics 130

Drug Discovery World

FEBRUARY 16, 2023

Dr Ouvry will be responsible for managing internal and external resources to advance the company’s pre-clinical pipeline of small molecule assets which inhibit the mitochondrial permeability transition pore (mPTP) through a novel MOA. Wang Zilong, H.E.L Group: H.E.L

Small Molecule 130

Small Molecule Pharmaceuticals Clinical Development Science 130

Drug Discovery World

FEBRUARY 27, 2023

For RNA, we’ve seen its success with Covid-19 vaccines and the approval of the first-ever RNA-targeting small molecule, risdiplam, for treating spinal muscular atrophy (SMA). Do you have any therapeutic targets in mind for your first small molecule drug candidate? RT : Currently, we are developing our internal pipeline.

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RNA Science Small Molecule Engineering 130

Dark Matter Blog

JANUARY 16, 2023

Our terra firma is small-molecule medicines. As we know, small molecules have been the mainstay of our pharmacopeia for several centuries and have, almost without exception, targeted proteins. This is why Arrakis set out in 2015 on an expedition to figure out how to develop small molecules that can target RNA.

Small Molecule 52

Small Molecule RNA International Disease 52

Covalent Modifiers

JULY 21, 2023

This allowed for tracking of PTK7 expression, localization, and cellular internalization. These studies validate the programmability of covalent aptamers and highlight their applicability in a cellular context, including protein and small molecule delivery

Small Molecule 52

Small Molecule International 52

Drug Discovery World

APRIL 6, 2023

from Fabien Vincent, Pfizer, Groton, US High content phenotypic and pathway profiling identifies novel drug mechanisms-of-action tailored towards cancers of unmet need by Neil Carragher, University of Edinburgh, Edinburgh, UK Functional genomics as an enabling tool for phenotypic screening by Matthew Garnett Chemistry to the Clinic: Part 1-3: (..)

Small Molecule 130

Small Molecule Targeted Protein Degradation Clinical Trials Engineering 130

Drug Target Review

JULY 13, 2023

They found that although the targets themselves may not be easily druggable due to their disordered nature, their ability to condense can be modulated using small molecules. By focusing on molecules that modulate the condensate formation, they identified tractable chemical matter that specifically impacted the target of interest.

Disease 98

Disease Small Molecule Cell Biology Medical Schools 98

Drug Target Review

AUGUST 25, 2023

However, in tissues where the 3 Hs are not present, the small molecule has anti-toxicity activity through 1) direct inhibition of the NLRP3 inflammasome, an inflammation starter and perpetuator, and 2) upregulation of the master antioxidant transcription factor, Nrf2.

Small Molecule 98

Small Molecule Virus International Clinical Trials 98

LifeSciVC

JULY 6, 2023

Although these results cannot prove that there is no possibility of finding a high-affinity small molecule binder of NBD1, they are discouraging…” It turns out the small molecules they were looking for are not only possible – they were ready for a dedicated team to push them ahead.

Small Molecule 48

Small Molecule Licensing Licensing Science 48

Drug Discovery World

MAY 10, 2023

The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) issues guidelines and develops testing strategies for evaluating carcinogenicity along with other risks such as genotoxicity, immunotoxicity, and reproductive toxicity.

Small Molecule 130

Small Molecule Pharmaceutical Companies Animal Testing Pharmaceuticals 130

Drug Discovery World

APRIL 27, 2023

San Diego, California At the time of writing, the DDW team are in San Diego for SLAS2023 International Conference and Exhibition, which speaks to this Californian city’s appropriateness for such an integral event within the industry. We’re observing many stakeholders move to San Diego from other US hubs like Boston.

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Small Molecule Science Drugs FDA Approval 130