Drug Target Review

DECEMBER 13, 2024

2 Unmet needs in lung cancer treatment Recent decades have seen significant advancements in lung cancer treatment, especially with the introduction of targeted therapies and immunotherapies, which have notably improved survival rates. These can include anti-tubulin compounds, potentially reducing side effects and improving quality of life.

Therapies 98

Therapies Treatment Clinical Trials Drugs 98

ASPET

SEPTEMBER 28, 2023

Benzodiazepine pharmacoresistance is thought in part to result from internalization of synaptic GABA A receptors, which are the main target of the drug. The naturally occurring neurosteroid allopregnanolone is a therapy of interest against SE for its ability to modulate all isoforms of GABA A receptors.

Therapies 100

Therapies Treatment International Drugs 100

DrugBank

JUNE 13, 2024

Unlike traditional oral medications with limited bioavailability and potential for erratic absorption, IDDS function as internal drug repositories, delivering precise doses of medication directly at the site of action or into the systemic circulation via precisely adjusted release mechanisms. 

Therapies 74

Therapies Drugs DNA Treatment 74

PPD

DECEMBER 16, 2024

Rising costs have become a persistent challenge for drug developers, driven by a combination of internal and external pressures that have intensified in recent years. Lacking internal expertise or capacity often slows progress, making outsourcing a strategic necessity.

Drug Development 52

Drug Development Clinical Trials Compliance Trials 52

Drug Target Review

DECEMBER 11, 2024

By employing advanced analytical techniques like high-resolution mass spectrometry (HRMS) and carefully calibrating systems with optimal internal standards (IS), we effectively mitigate matrix effects and provide reliable preclinical toxicology data. These solutions must contain analytes and internal standards at known concentrations.

International 52

International Laboratories Drugs Pharmacokinetics 52

SCIENMAG: Medicine & Health

JUNE 21, 2023

New research published in the Journal of Internal Medicine demonstrates that optogenetics—which uses light-sensitive proteins to control the activity of targeted cells—is a promising shock-free approach to treating atrial fibrillation (AF), or an irregular, often rapid heart rate, for immediate restoration of regular rhythm.

Therapies 64

Therapies International Treatment Research 64

ASPET

AUGUST 2, 2024

Based on previous studies, we hypothesized that vascular senescence increases the risk of bleeding during warfarin therapy. After validating the models, we examined changes in the International Normalized Ratio (INR) at fixed warfarin doses (0.20 This study aimed to explore these effects using animal models and clinical cohorts.

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Drug Target Review

SEPTEMBER 6, 2024

What trends are driving the increased use of in vivo delivery methods in gene therapy? Generally, the amount of lentiviral vector that is used for in vivo gene therapy is larger than for ex vivo use. How are new therapeutic areas emerging as potential targets for in vivo gene therapy?

Therapies 59

Therapies Vaccine Marketing Disease 59

ASPET

NOVEMBER 17, 2023

This response may result from gamma-aminobutyric acid A receptors (GABA A R) internalization that follows prolonged SE; this receptor trafficking results in fewer GABA A R in the synapse to restore inhibition. Benzodiazepine pharmacoresistance develops when treatment of status epilepticus (SE) is delayed.

Treatment 100

Treatment Therapies International Drugs 100

SCIENMAG: Medicine & Health

JUNE 15, 2023

A new therapy is on the horizon for patients with metastatic colorectal cancer who have run out of treatment options. Credit: Vanderbilt University Medical Center A new therapy is on the horizon for patients with metastatic colorectal cancer who have run out of treatment options.

Treatment 83

Treatment Clinical Trials Therapies International 83

Drug Target Review

FEBRUARY 13, 2024

In light of the International Day of Women and Girls in Science, which celebrates the achievements of women in STEM, could you share an example of a project or research that has been particularly impactful within your field? I started my career in the early stages of the targeted approach to drug therapies.

International 59

International Science Drugs Engineering 59

Drug Target Review

OCTOBER 30, 2024

Organoids will play increasingly crucial roles not only in research and diagnostics, but also in therapies to restore and enhance the human body. About the author Anirban Datta, Head of Discovery Biology at Verseon International Corporation Anirban Datta PhD is the head of discovery biology at Verseon International Corporation.

Treatment 106

Treatment Disease Clinical Trials Molecular Biology 106

Advarra

JUNE 13, 2023

Research in gene therapies and genetically engineered drugs and vaccines are growing exponentially, and will only continue to become more popular. The accelerating gene therapy market is expected to grow globally by 16.6% As more therapies are moving out of the lab and into human clinical trials, this paradigm is changing.

Therapies 52

Therapies Research Clinical Trials Trials 52

FDA Law Blog: Drug Discovery

NOVEMBER 2, 2023

Lewis, Senior Regulatory Device & Biologics Expert — On October 20, 2023, FDA announced the availability of the final guidance authored by CBER titled “Voluntary Consensus Standards Recognition Program for Regenerative Medicine Therapies.” It finalized a draft guidance published in 2022.

Therapies 59

Therapies FDA Production Regulations 59

The Pharma Data

JULY 15, 2021

Amgen Inflammation Amgen brings therapies to millions of people with inflammatory diseases, with a focus on serving unmet patient needs. In doing so, we have introduced and evolved novel therapies that have changed the lives of patients. It’s a commitment that extends beyond introducing novel therapies. Source link:

International 52

International Disease Treatment Science 52

The Pharma Data

JULY 23, 2021

(Nasdaq: BIIB) today announced it will share multiple oral and poster presentations from its Alzheimer’s disease clinical development portfolio at the Alzheimer’s Association International Conference (AAIC), which will be held in Denver, Colorado and online July 26-30, 2021.

International 52

International Disease Clinical Trials Trials 52

Codon

NOVEMBER 3, 2024

The experience showed me that new therapies are needed not only to meet the targets laid out by the End TB Strategy but also to prevent drug resistance from negating the effectiveness of current therapeutics. When I interned in the TB laboratory as a biology student intrigued by infectious diseases, I knew very little about this condition.

Vaccine 92

Vaccine Trials Therapies Clinical Trials 92

Drug Patent Watch

DECEMBER 9, 2024

While the compound itself couldn’t be patented, various derivatives and combination therapies have been patented, allowing for continued development and distribution. Artemisinin: Nobel Prize-Winning Malaria Treatment Artemisinin, derived from the sweet wormwood plant, has become a crucial treatment for malaria.

Drugs 97

Drugs Drug Development Pharmaceuticals Production 97

The Pharma Data

AUGUST 30, 2021

.–(BUSINESS WIRE)– Showcasing Teva’s Commitment to Helping Patients Have More Migraine-Free Days, 18 Abstracts will be presented, Including One Late-Breaker, on AJOVY ® (fremanezumab-vfrm) Injection at the International Headache Society and European Headache Federation Joint Congress 2021. Teva Pharmaceuticals USA, Inc.,

International 52

International Clinical Trials Treatment Trials 52

The Pharma Data

MAY 6, 2021

INDIANAPOLIS , May 6, 2021 /PRNewswire/ — With a goal of integrating data and technology to help streamline diabetes management, Eli Lilly and Company (NYSE: LLY) signed strategic international agreements with four companies – DexCom, Inc., 1 International Diabetes Federation. Glooko Inc. IDF Diabetes Atlas, 9 th edn.

International 52

International Therapies Disease Production 52

Drug Target Review

JANUARY 14, 2025

Based in South Africa, she has worked extensively with international biotech companies, specialising in therapeutic development for ageing-related diseases and complex conditions such as glioblastoma and autosomal dominant polycystic kidney disease (ADPKD).

Drugs 69

Drugs Protein Expression Science Research 69

The Pharma Data

SEPTEMBER 9, 2021

This data will be presented as a late-breaker ePoster during the International Headache Society (IHS) and European Headache Federation (EHF) Joint Congress taking place virtually on Sept. If a hypersensitivity reaction occurs, consider discontinuing AJOVY and institute appropriate therapy. 8-12, 2021. Please click here for full U.S.

International 52

International Treatment Clinical Trials Trials 52

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union. Molecular Therapy 20 , 1831-1832 (2012). Nature 578 , 229-236 (2020).

Engineering 105

Engineering Virus Therapies Immune Response 105

KIF1A

JULY 8, 2023

Notably, last month the FDA granted accelerated approval to a gene therapy for Duchenne Muscular Dystrophy (DMD), a genetic muscle-wasting disorder that primarily impacts boys. Assessments of clinical benefits are still underway, reflecting the FDA’s commitment to accelerated approval of gene therapies for rare disorders.

Therapies 98

Therapies Regulations FDA Treatment 98

The Pharma Data

MAY 26, 2023

State-of-the-art cryogenic freezers alongside material transfer equipment have been installed that are designed to retain the integrity of investigational advanced therapy products by minimizing their time-out-of-environment. With sites in the U.S.,

Clinical Supply 52

Clinical Supply Therapies Clinical Trials Packaging 52

Drug Target Review

NOVEMBER 6, 2023

2 It is this complexity that necessitates powerful, targeted combination therapies. 4, 5 More recently, new combination regimens have emerged that incorporate targeted therapies to treat a variety of blood cancers, including multiple myeloma (MM), chronic lymphocytic leukaemia (CLL) and acute myelogenous leukaemia (AML).

Small Molecule 111

Small Molecule Therapies Treatment Disease 111

Vial

DECEMBER 11, 2023

In the decades since its identification in 1989, advances in clinical research for new Hepatitis C therapies and the introduction of direct-acting antiviral agents (DAAs) have led to viral eradication in more than 98% of patients, resulting in HCV crossing from manageable to being the first curable , chronic viral infection.

Clinical Research 52

Clinical Research Therapies Research Vaccine 52

Drug Target Review

AUGUST 17, 2023

This novel mouse model, in addition to a previously generated human FcγRIIB transgenic (Tg) mouse, along with a panel of FcγRIIB mAbs, were used to develop a deeper understanding of FcγRIIB’s inhibitory functions during mAb immunotherapy and how optimal targeting of FcγRIIB would potentiate mAb therapy. 2011 Sep 1;118(9):2530-40. Cancer Cell.

International 98

International Therapies Regulations Clinical Trials 98

The Pharma Data

MAY 27, 2022

Novartis today announced the US Food and Drug Administration (FDA) has granted accelerated approval for Kymriah ® (tisagenlecleucel) for the treatment of adult patients with relapsed or refractory (r/r) follicular lymphoma (FL) after two or more lines of systemic therapy.

FDA Approval 52

FDA Approval Therapies FDA Treatment 52

Advarra

MARCH 6, 2025

Furthermore, Advarras IRB includes hundreds of expert members, many of whom bring expertise and experience in several therapeutic areas and disciplines, including oncology, bioethics, investigational pharmacy, internal medicine, psychology, physiology, radiology, public health, pediatrics, nursing, and social and behavioral science.

Clinical Research 52

Clinical Research Research Clinical Trials Bioethics 52

PPD

OCTOBER 31, 2024

These internal issues are compounded by external pressures like inflation, the development of innovative therapies that require complex protocols and the need to comply with shifting regulatory requirements.

Drug Development 52

Drug Development Clinical Trials Trials Drugs 52

SCIENMAG: Medicine & Health

JULY 18, 2023

It’s time to stop prevaricating and explore the use of psilocybin—the active ingredient in ‘magic mushrooms’—and other psychedelics to ease the often overwhelming distress faced by women with late stage gynaecological cancers, urge doctors in a commentary published online in the International Journal of Gynecological Cancer.

Doctors 68

Doctors International Therapies 68

The Pharma Data

SEPTEMBER 11, 2021

– Designation is based on results from the EMPEROR-Preserved phase III trial, which established Jardiance as the first therapy to show statistically significant improvement in heart failure outcomes in adults with heart failure with preserved ejection fraction. vice president, Product Development, Lilly. About EMPEROR-Preserved.

Therapies 52

Therapies FDA Hospitals FDA Approval 52

Drug Target Review

DECEMBER 28, 2023

In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. However, if the therapy targets only the subclonal (branch) mutations, this will result in the mere ‘pruning’ of specific branches rather than elimination of the whole cancer.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

SCIENMAG: Medicine & Health

JUNE 28, 2023

An international team of researchers has developed a new method to deliver drugs into the inner ear. When combined to deliver a gene therapy that repairs inner ear hair cells, the researchers […]

International 65

International Therapies Research Drugs 65

Drug Target Review

JUNE 29, 2023

I think the cell-therapy field has evolved a lot – and is continuing to do so – in the time I’ve been working with this. Regarding the NY-ESO programme that we worked on, I started work on that in 2002 before we even knew that we were going to do cell therapy. I mean, I think cell-therapy is an great place to be.

Therapies 116

Therapies Science Production Cell Biology 116

PPD

MARCH 13, 2024

Within cell therapy clinical trials, apheresis collections contribute to the specific constituents of the given therapy. Whether this is via an allogeneic (healthy donors) or autologous (patient) approach, the material collected is then manufactured and returned to patients for infusion therapy.

Clinical Development 98

Clinical Development Clinical Trials Therapies Trials 98