Drug Discovery World

FEBRUARY 13, 2024

AM1476, a first-in-class, peripheral-acting serotonin receptor antagonist, has been granted US and EU Orphan Drug Designation as an anti-fibrotic treatment for systemic sclerosis. There are currently no treatments on the market that effectively stop or reverse scarring in both skin and lung tissue.

Disease 130

Disease Treatment Small Molecule Pharmacokinetics 130

Drug Discovery World

DECEMBER 18, 2023

The international team from the University of Cambridge, Scotland, the USA and Sri Lanka used a combination of approaches including human genetics, new ways of measuring hormones in pregnant women’s blood, and studies in cells and mice.

Treatment 130

Treatment Hospitals International Science 130

Drug Discovery World

APRIL 11, 2023

Owing to the complexity of severe asthma, many patients have unclear or multiple drivers of airway inflammation resulting in some patients not responding to the current standard of treatment, and being at increased risk of asthma attacks, hospitalisations, and a poor quality of life 3,4,5,6. Final draft guidance is subject to appeal.

Treatment 246

Treatment Clinical Trials Trials Science 246

Drug Discovery World

MAY 28, 2023

The International Day of Action for Women’s Health has been celebrated on 28 May every year since 1987. Despite the high prevalence of the condition and the debilitating day-to-day effects it has, there are currently no drug treatments approved that restore function and have a long-term effect.

International 130

International Vaccine Nurses Clinical Trials 130

Drug Discovery World

AUGUST 2, 2022

An international team of researchers has won £30 million for its work in developing a potential cure for inherited heart muscle conditions in young people. . The post International researchers win £30m for work in treating heart conditions appeared first on Drug Discovery World (DDW).

International 130

International Research DNA Clinical Trials 130

Drug Discovery World

FEBRUARY 16, 2023

Minoryx Therapeutics has revealed the findings from the first and largest international study to enroll adult male X-linked adrenoleukodystrophy patients. Treatment with leriglitazone also significantly reduced plasma levels of MMP-9, a marker of blood-brain barrier integrity.

Treatment 130

Treatment Disease Clinical Trials International 130

Drug Discovery World

AUGUST 8, 2022

Earlier this year, pharmaceutical company Novo Nordisk announced positive results from Phase I & II clinical trials investigating its antibody treatment for haemophilia A. . SS: Mim8 is a next-generation human IgG4 bispecific antibody for treatment of haemophilia A regardless of inhibitor status.

Treatment 130

Treatment Clinical Trials International Disease 130

Drug Discovery World

MARCH 16, 2023

Overcoming Resistance to FLT3 Inhibitors in the Treatment of FLT3-Mutated AML. International Journal of Molecular Science, 21(4): 1537. Around one third of patients with AML are diagnosed with FLT3-mutations, which are associated with a higher risk of relapse and poor clinical outcome. and Leung, A. and Wang, H-G.

Treatment 130

Treatment FDA FDA Approval Drug Development 130

Drug Discovery World

FEBRUARY 9, 2023

The Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorisation to AstraZeneca for Imfinzi (durvalumab) in combination with gemcitabine and cisplatin in Great Britain for use as a first-line treatment of adults with locally advanced, unresectable or metastatic biliary tract cancer (BTC). versus 11.5%).

Treatment 130

Treatment Clinical Research International FDA 130

Drug Discovery World

DECEMBER 13, 2022

In the international Phase IIb study, 274 patients were recruited and randomly assigned 1:1:1:1:1 to rocatinlimab every four weeks (150mg or 600mg) or every two weeks (300 mg or 600 mg) or subcutaneous placebo up to week 18, with an 18-week active-treatment extension and 20-week follow-up. . Clinical trial details.

Treatment 130

Treatment Clinical Trials Laboratories Therapies 130

Common Sense for Drug Policy Blog

APRIL 21, 2024

Agonist Treatment for Cannabis Use Disorder "Cannabinoid agonist treatment is unlikely to be an approach relevant to all cannabis users seeking treatment, as evidenced by the large numbers of individuals who did not complete the study screening process, and the modest 12-week treatment retention rates. JAMA Intern Med.

Treatment 52

Treatment Clinical Trials International Therapies 52

SCIENMAG: Medicine & Health

JUNE 15, 2023

A new therapy is on the horizon for patients with metastatic colorectal cancer who have run out of treatment options. Credit: Vanderbilt University Medical Center A new therapy is on the horizon for patients with metastatic colorectal cancer who have run out of treatment options.

Treatment 83

Treatment Clinical Trials International Therapies 83

Drug Discovery World

JULY 14, 2022

Biotech company Actigen has moved closer to clinical trials for rare disease treatment for Hunter syndrome, following a pre-Investigational New Drug (IND) meeting with the US Food and Drug Administration (FDA). ? . It occurs primarily in males and current treatment options such as enzyme replacement therapy, only offer a partial solution.

Clinical Trials 130

Clinical Trials Trials Treatment Disease 130

National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

Kendal Chidwick NDARC’s Kendal Chidwick discusses the findings from a recently published study that examined how patterns of opioid agonist treatment medicines have changed over the past decade. Other changes around this time aimed at improving treatment accessibility included increased use of take-home doses and telehealth appointments.

Treatment 133

Treatment Community Pharmacies Pharmacy International 133

SCIENMAG: Medicine & Health

MARCH 15, 2024

The liver is not only the largest internal organ but also vital for human life as a metabolic center. It also possesses remarkable self-healing powers: even when large portions are removed, such as during surgery, they quickly regenerate in healthy individuals.

Treatment 86

Treatment International 86

Drug Discovery World

JULY 13, 2022

The first new treatment in 20 years that prevents a common, painful side-effect in patients with sickle cell disorder (SCD) has been issued interim acceptance by the Scottish Medicines Consortium (SMC). . Not all patients respond to the current treatment options available, and so there is a significant unmet need in managing this disease.

Treatment 130

Treatment Hospitals International Disease 130

Broad Institute

NOVEMBER 7, 2023

While RA therapies targeted to specific inflammatory pathways have emerged, only some patients’ symptoms improve with treatment, emphasizing the need for multiple treatment approaches tailored to different disease subtypes. They also found that patients’ CTAPs were dynamic and could change over time in response to treatment.

Treatment 96

Treatment RNA Hospitals Disease 96

SCIENMAG: Medicine & Health

SEPTEMBER 17, 2023

The early treatment of obesity in children is effective in both the short and long term, researchers from Karolinska Institutet report in a study published in The International Journal of Obesity.

Treatment 52

Treatment International Research 52

SCIENMAG: Medicine & Health

AUGUST 14, 2023

Among the various types of cancer, lung cancer stands out as the most prevalent, posing significant challenges in terms of treatment due […] Similarly, cancer was the primary cause of death in 2020.

International 77

International Treatment 77

Drug Discovery World

JUNE 27, 2024

The trial assessed both once-weekly and once-monthly prophylactic treatment with the investigational treatment Mim8. The data were presented at the International Society of Thrombosis and Haemostasis Annual Congress (ISTH 2024) in Bangkok, Thailand. for those who received no prior prophylaxis treatment.

FDA Approval 147

FDA Approval Trials Treatment Hospitals 147

Drug Discovery World

MAY 10, 2024

Study 008A Study 008A was a four-week, international, randomised, double-blind and placebo-controlled add-on Phase II/III study performed in 45 centres in 11 countries in Europe, Asia and Latin America. 291 patients were randomised to treatment either with evenamide or placebo as add-on to their current antipsychotic therapy.

International 182

International Pharmaceuticals Treatment Trials 182

Drug Discovery World

FEBRUARY 16, 2024

Emmanuel Caeymaex, Executive Vice President, Immunology Solutions, and Head of US, UCB, said: “Results presented re-affirm the high levels of sustained clinical response achieved with bimekizumab treatment, the positive impact on health-related quality of life as reported by patients, and the importance of timely treatment following diagnosis.”

International 130

International Treatment Hospitals Clinical Trials 130

Drug Discovery World

MAY 30, 2024

Atrogi’s CEO, Alexandra Ekman Ryding, said: “This publication highlights strong pre-clinical data relating to ATR-127 and validates our approach for the development of a novel modality for the treatment of obesity. We believe our pioneering dual receptor beta-agonist approach has the potential to transform the obesity treatment landscape.

Small Molecule 147

Small Molecule Treatment International Production 147

Common Sense for Drug Policy Blog

JUNE 4, 2023

Heroin Treatment in the UK "Heroin Assisted Treatment (HAT) is an alternate treatment modality for people for whom more traditional forms of OST have been ineffective. Despite a robust international evidence base for the social and health benefits of HAT ( Haasen et al., 2010 ; van den Brink et al., patient safety (i.e.

Treatment 40

Treatment International Government Trials 40

Drug Discovery World

JANUARY 5, 2024

The top stories: China’s NMPA okays maribavir for post-transplant cytomegalovirus Takeda’s Livtencity (maribavir) has been approved in China for the treatment of adult patients with post-hematopoietic stem cell transplant (HSCT) or solid organ transplant (SOT) cytomegalovirus (CMV) infection/disease.

International 130

International Drugs FDA Regulations 130

Drug Discovery World

JANUARY 30, 2024

A UK-based start-up is developing technology to build a pharmaceuticals factory in space that will make antibody treatments more accessible and easier to administer. Long term, our vision is to establish a pharmaceutical manufacturing facility in space within the next decade, enabling patients to access treatment conveniently at home.”

Pharmaceuticals 245

Pharmaceuticals Hospitals International Treatment 245

Drug Discovery World

AUGUST 2, 2023

Renaissance Pharma has announced its first development programme focused on Hu14.18, a humanised anti-GD2 monoclonal antibody (mAb), licensed from St Jude Children’s Research Hospital for the treatment of newly diagnosed high-risk neuroblastoma. A novel Phase II trial incorporating Hu14.18 and three-year event-free (EFS) of 73.7%.

Licensing 246

Licensing Licensing Hospitals Therapies 246

Drug Discovery World

NOVEMBER 28, 2023

An international team of scientists has shown that a stem cell therapy for multiple sclerosis (MS) could prevent further damage to the brain. This was a very small, early-stage study and we need further clinical trials to find out if this treatment has a beneficial effect on the condition.

Therapies 264

Therapies Clinical Trials Trials Treatment 264

Drug Discovery World

OCTOBER 9, 2023

Positive Phase I trial data indicates that Reqorsa (quaratusugene ozeplasmid) has shown early efficacy for the treatment of non-small cell lung cancer (NSCLC). The data will be presented at the 2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.

Therapies 277

Therapies Clinical Trials Trials International 277

Common Sense for Drug Policy Blog

JUNE 4, 2023

Opioid Substitution Treatment in the UK "Opioid substitution therapy (OST) is an evidence-based treatment for opioid dependency, with treatment engagement shown to be protective against drug related deaths ( Santo et al., The International journal on drug policy , 116 , 104025. 2019 ; Public Health England, 2018 ).

Treatment 40

Treatment Pharmacy International Therapies 40

Drug Discovery World

MARCH 11, 2024

The US Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) to iOnctura for its autotaxin inhibitor cambritaxestat for the treatment of pancreatic cancer. Following a separate submission process the World Health Organization has proposed the International Nonproprietary Name (INN) of cambritaxestat.

Therapies 173

Therapies Drugs FDA International 173

Drug Discovery World

NOVEMBER 16, 2023

An international research team is the first to use artificial intelligence (AI) analysis to identify dual-purpose target candidates for the treatment of cancer and ageing. Of these, 22 were proposed as dual-purpose targets for anti-ageing and anti-cancer treatment with the same therapeutic direction.

Engineering 200

Engineering Treatment International Research 200

The Pharma Data

JULY 23, 2021

(Nasdaq: BIIB) today announced it will share multiple oral and poster presentations from its Alzheimer’s disease clinical development portfolio at the Alzheimer’s Association International Conference (AAIC), which will be held in Denver, Colorado and online July 26-30, 2021. ADUHELM is indicated for the treatment of Alzheimer’s disease.

International 52

International Disease Clinical Trials Trials 52

SCIENMAG: Medicine & Health

OCTOBER 20, 2023

Now an international team led by the Hudson Institute of Medical Research has found a way to determine which species are important and how they interact to create a healthy microbiome. The more diverse species in your gut, the better it is for your health. Credit: Hudson Institute of Medical Research The more diverse species […]

Treatment 52

Treatment Disease International Research 52

Drug Discovery Today

NOVEMBER 10, 2022

A team of surgeons and scientists from the UK, Sweden and Canada, funded by Rinri Therapeutics, has confirmed secure surgical access to the central core of the human cochlea The research, published in Scientific Reports, is critical to the first in-human trials of new cell, gene and drug therapies for the inner ear, and will assist with treatment for (..)

International 100

International Research Therapies Trials 100

Drug Discovery World

JUNE 25, 2024

“Diseases like dementia with Lewy bodies, or Parkinson’s disease, or Alzheimer’s disease are debilitating, and we don’t really have any good treatments that can modify the disease progression,” explained lead study author Jacob Simmering, UI Assistant Professor of Internal Medicine.

Drugs 147

Drugs Disease International Production 147

Drug Discovery World

JUNE 12, 2024

GLP-1RAs are a breakthrough class of drugs for the treatment of diabetes that have produced impressive results in a number of studies by mimicking GLP-1 in the body. Nonetheless, oral GLP-1RAs represent a multifaceted approach to the treatment of diabetes and related metabolic conditions.

Drugs 219

Drugs FDA Approval Treatment Compliance 219