Drug Target Review

DECEMBER 9, 2024

Baker’s model could revolutionise drug development, synthetic biology, and nanotechnology, opening possibilities for new medical treatments, vaccines, nanomaterials, and sensors. The Rosetta algorithm has been incorporated into AI-powered tools like RoseTTAfold, which uses a three-track neural network to predict protein structures.

Engineering 106

Engineering International Drug Development Science 106

Drug Target Review

DECEMBER 13, 2024

2 Unmet needs in lung cancer treatment Recent decades have seen significant advancements in lung cancer treatment, especially with the introduction of targeted therapies and immunotherapies, which have notably improved survival rates. 18 Indeed, early-phase clinical studies exploring TsAbs in solid tumours have recently commenced.

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Therapies Treatment Clinical Trials Drugs 98

SCIENMAG: Medicine & Health

MARCH 15, 2024

The liver is not only the largest internal organ but also vital for human life as a metabolic center. It also possesses remarkable self-healing powers: even when large portions are removed, such as during surgery, they quickly regenerate in healthy individuals.

Treatment 86

Treatment International 86

SCIENMAG: Medicine & Health

AUGUST 14, 2023

Among the various types of cancer, lung cancer stands out as the most prevalent, posing significant challenges in terms of treatment due […] Similarly, cancer was the primary cause of death in 2020.

International 77

International Treatment 77

ASPET

NOVEMBER 17, 2023

Benzodiazepine pharmacoresistance develops when treatment of status epilepticus (SE) is delayed. This response may result from gamma-aminobutyric acid A receptors (GABA A R) internalization that follows prolonged SE; this receptor trafficking results in fewer GABA A R in the synapse to restore inhibition.

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Treatment Therapies International Drugs 100

Drug Patent Watch

DECEMBER 9, 2024

Taxol: From Pacific Yew to Cancer Treatment Taxol (paclitaxel), a widely used cancer drug, was originally isolated from the bark of the Pacific yew tree. Artemisinin: Nobel Prize-Winning Malaria Treatment Artemisinin, derived from the sweet wormwood plant, has become a crucial treatment for malaria.

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Drugs Drug Development Pharmaceuticals Production 97

Common Sense for Drug Policy Blog

APRIL 21, 2024

Agonist Treatment for Cannabis Use Disorder "Cannabinoid agonist treatment is unlikely to be an approach relevant to all cannabis users seeking treatment, as evidenced by the large numbers of individuals who did not complete the study screening process, and the modest 12-week treatment retention rates. JAMA Intern Med.

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Treatment Clinical Trials International Therapies 52

SCIENMAG: Medicine & Health

SEPTEMBER 17, 2023

The early treatment of obesity in children is effective in both the short and long term, researchers from Karolinska Institutet report in a study published in The International Journal of Obesity.

Treatment 52

Treatment International Research 52

PLOS: DNA Science

SEPTEMBER 5, 2024

Diagnosis began to shift from a body-part basis to a molecular one, which I wrote about in “Mutation and location important in cancer treatment” for The Lancet in 2015. The researchers tested the model on 19 types of cancers, and validated the findings among several international patient groups.

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Treatment FDA Approval DNA Small Molecule 71

Policy Prescription

OCTOBER 22, 2024

Harvard doctors and public health experts recommend using the website PharmacyChecker.com to find international online pharmacies to order more affordable prescription drugs for personal importation when domestic savings strategies fail. They offer this advice in a new article in the Journal of the American Medical Association.

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Online Pharmacies Pharmacy Drugs FDA Approval 113

Drug Discovery Today

MARCH 1, 2022

People suffering from COVID-19 could have several different SARS-CoV-2 variants hidden away from the immune system in different parts of the body, finds new research published in Nature Communications by an international research team.

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Virus Research International Treatment 100

Advarra

MARCH 6, 2025

For more than 35 years, Advarra has been committed to protecting the rights and welfare of clinical trial participants while helping to improve healthcare outcomes, advancing medical knowledge, and bringing innovative, life-extending treatments to market that benefit millions of patients worldwide.

Clinical Research 52

Clinical Research Research Clinical Trials Bioethics 52

Chemical Biology and Drug Design

JANUARY 15, 2024

Subsequently, the ultrasonic diagnostic apparatus was adopted to assess and compare the left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular internal diameter at end diastole (LVIDd), and left ventricular internal diameter at end systole (LVIDs) in rats.

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Disease International Regulations Treatment 100

Drug Target Review

DECEMBER 11, 2024

By employing advanced analytical techniques like high-resolution mass spectrometry (HRMS) and carefully calibrating systems with optimal internal standards (IS), we effectively mitigate matrix effects and provide reliable preclinical toxicology data. These solutions must contain analytes and internal standards at known concentrations.

International 52

International Laboratories Drugs Pharmacokinetics 52

Codon

NOVEMBER 3, 2024

In the 1924 novel, The Magic Mountain , Thomas Mann describes a sanatorium patient named Anton Ferge as he undergoes a painful tuberculosis (TB) treatment. Over time, the frequency of resistance gene variants in the population will continue increasing because only the bacteria lacking those variants will die with treatment.

Vaccine 92

Vaccine Trials Therapies Clinical Trials 92

Drug Target Review

MARCH 19, 2024

In the current study undertaken by an international team of researchers, co-led by Dr William Reay, we used the genetics of retinol itself as a way to proxy its effect in thousands of traits, including brain structure, vision, and the immune system through causal modelling.

Laboratories 106

Laboratories Bioinformatics International Research Laboratories 106

ASPET

SEPTEMBER 28, 2023

Status epilepticus (SE) is a life-threatening development of self-sustaining seizures that becomes resistant to benzodiazepines when treatment is delayed. Benzodiazepine pharmacoresistance is thought in part to result from internalization of synaptic GABA A receptors, which are the main target of the drug.

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Therapies Treatment International Drugs 100

Alta Sciences

SEPTEMBER 13, 2023

Four Pain Models Altasciences Uses to Assess Treatments During Clinical Trials pmjackson Wed, 09/13/2023 - 17:01 September is pain awareness month, and the importance of pain management and continued research into effective analgesics is integral to helping patients suffering from various pain conditions.

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Clinical Trials Treatment Trials Drug Development 52

FDA Law Blog: Biosimilars

DECEMBER 4, 2023

A prescription not issued in the usual course of professional treatment or in legitimate, authorized research is not a prescription within the meaning of the CSA and the pharmacist knowingly filling it, along with the prescriber issuing it, is subject to penalties. 21 U.S.C. § 829; 21 C.F.R. Complaint ¶ 58. Complaint ¶ 59.

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Pharmacy Government Treatment Compliance 139

SCIENMAG: Medicine & Health

OCTOBER 20, 2023

Now an international team led by the Hudson Institute of Medical Research has found a way to determine which species are important and how they interact to create a healthy microbiome. The more diverse species in your gut, the better it is for your health. Credit: Hudson Institute of Medical Research The more diverse species […]

Treatment 52

Treatment Disease International Research 52

PPD

DECEMBER 16, 2024

Rising costs have become a persistent challenge for drug developers, driven by a combination of internal and external pressures that have intensified in recent years. Each delay not only increases costs but also jeopardizes a treatments viability, underscoring the urgency for efficient timelines and streamlined processes.

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Drug Development Clinical Trials Compliance Trials 52

The Pharma Data

MAY 19, 2023

HIGH SCHOOL SCIENTISTS AND ENGINEERS WIN NEARLY $9 MILLION AT THE REGENERON INTERNATIONAL SCIENCE AND ENGINEERING FAIR 2023 Regeneron Pharmaceuticals, Inc. Congratulations to the Regeneron International Science and Engineering Fair 2023 winners,” said Maya Ajmera, President and CEO, Society for Science and Executive Publisher, Science News.

Engineering 52

Engineering International Science Virus 52

Drug Target Review

DECEMBER 21, 2023

Researchers at the Allen Institute for Cell Science , a division of the Allen Institute in Seattle, US, developed a unique mathematical framework to uncover internal organisation of cellular structures in human induced pluripotent stem cells (hiPSCs) while taking account of the wide range of variation that naturally occurs in cell shapes.

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International Science Disease Research 106

The Pharma Data

APRIL 12, 2022

The decision was taken at the inaugural International Strategic Dialogue on Noncommunicable Diseases (NCDs) and the Sustainable Development Goals, held today in Accra, Ghana, where a new Global Compact on NCDs was launched. The economic, as well as the health, benefits of investing in NCDs was a clear theme at the Dialogue.

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International Disease Government Treatment 52

Drug Target Review

DECEMBER 6, 2024

In cases where control or treatment groups show large variability, this could reflect true biological responses to a treatment, and removing such data could reduce the accuracy of the analysis. It is crucial during this phase to strike a balance between removing erroneous data and preserving meaningful biological variability.

RNA 52

RNA Drugs Research Science 52

The Pharma Data

FEBRUARY 24, 2022

Today’s approval will provide a treatment option for a wider range of patients with heart failure,” said Norman Stockbridge, M.D., Despite therapies in multiple drug classes, mortality remains high and treatment options for a broader range of patients are needed.

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FDA Approval FDA Treatment Hospitals 52

The Pharma Data

APRIL 4, 2022

The high rate of unvaccinated people will continue to put a strain on hospitals and healthcare systems around the world, furthering the need for effective treatments for patients hospitalised with COVID-19,” said Levi Garraway, M.D., If approved, Actemra/RoActemra would be the first U.S. Roche also partnered with Gilead Sciences, Inc.,

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Treatment FDA Approval Clinical Trials FDA 52

The Open Targets Blog

FEBRUARY 29, 2024

You can see how gene expression changes in specific cell types or even individual cells, and get a much finer picture of how a disease or a treatment might impact the biology of a tissue. Open Targets actually has some research projects in this area.

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International Bioinformatics RNA Disease 58

Drug Target Review

SEPTEMBER 5, 2024

With all this experience, I was very excited to take on the CEO role for Alzinova, a company developing a vaccine and other treatments against Alzheimer’s disease. In addition to the previously mentioned new treatment for children with rare liver diseases, I foresee two other important fields and breakthroughs.

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Pharma Companies Licensing Licensing Disease 112

The Pharma Data

MAY 27, 2022

The FDA’s decision is informed by the results of Pfizer’s nonclinical studies and a Phase 2a clinical study of ervogastat/clesacostat, which showed that treatment with ervogastat/clesacostat reduced liver fat with a favorable safety and tolerability profile. Pfizer Inc. NYSE: PFE) today announced the U.S.

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Treatment FDA Therapies Vaccine 52

Broad Institute

JUNE 28, 2023

The findings, published today in Nature , could lead to new ways of guiding cancer treatment or developing targeted drugs. Towards treatments In nearly one-third of all cancers in TCGA, one arm of chromosome 8 is missing, but researchers had never been sure why this aneuploidy is so common.

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DNA Medical Schools Treatment Research 122

National Institute on Drug Abuse: Nora's Blog

AUGUST 28, 2024

Over the past two decades, substance use treatment admissions have increased among people aged 50 and over. Chronic pain is prevalent among older adults, and treatment for pain is less effective in this age group than it is in younger people; it negatively impacts quality of life and is a risk factor for cognitive decline and premature death.

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Treatment Research Disease Drugs 110

Drug Target Review

NOVEMBER 6, 2023

Advances in research and development and the utilisation of combination treatment strategies are revolutionising the haematology care landscape, but more must be done to address patients’ individual needs. Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium. References Blood Cancer UK. 2018;9:1300.

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Small Molecule Therapies Treatment Disease 111

Drug Target Review

OCTOBER 11, 2023

This momentous discovery has the potential to reshape how we approach the diagnosis, treatment, and prevention of this deadly disease. Prostate cancer is a complex and heterogeneous disease, and the quest to tailor treatment to individual patients has never been more crucial. However, this study comes with two important caveats.

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Research Disease Treatment DNA 98

ASPET

OCTOBER 20, 2023

The intentional release of chemical warfare agents (CWAs) during World War I caused life-long damage for survivors, and CWA use is outlawed by international treaties. Emergency treatment is limited to supportive care using bronchodilators to control airway constriction, and rescue with mechanical ventilation to improve gas-exchange.

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International Regulations Treatment Disease 100

Drug Target Review

SEPTEMBER 21, 2023

The findings supported the possibility put forward by Cotton et al (2016) concerning the chance of repurposing these drugs for adulticidal treatment. The available treatment for that is minor surgery -to remove the nodules. With accessible and effective treatments, this is feasible. doi: 10.1002/14651858.CD011146.pub2.

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Drugs Treatment Disease Research 106

PPD

OCTOBER 31, 2024

These internal issues are compounded by external pressures like inflation, the development of innovative therapies that require complex protocols and the need to comply with shifting regulatory requirements. This aims to ensure that treatments are effective across varied demographics and to address historical gaps in clinical research.

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Drug Development Clinical Trials Trials Drugs 52