Mogrify enters research collaboration with the MRC Laboratory of Molecular Biology
Drug Discovery Today
JANUARY 12, 2021
Exploratory research project aims to develop novel protein expression systems via cell reprogramming
Logistics in Focus: Orchestrating the Challenges of Cell Therapy
Conversations in Drug Development Trends
NOVEMBER 12, 2024
These advanced therapeutics harness the power of molecular biology to improve human health. Modifying and expanding the cells in a GMP laboratory. Despite their exciting potential, the smooth operation of cell therapy development trials requires extraordinary orchestration, perfectly aligning the product and patient journeys.
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Machine learning guides researchers to new synthetic genetic switches
Broad Institute
OCTOBER 23, 2024
What is special about these synthetically designed elements is that they show remarkable specificity to the target cell type they were designed for," said Ryan Tewhey, an associate professor at The Jackson Laboratory and co-senior author of the work with Steven Reilly of Yale, and Pardis Sabeti of the Broad. Chan School of Public Health. "By
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De-risking drug discovery with predictive AI
Broad Institute
JULY 17, 2024
As of now, papers describing three of these machine learning tools have been published, in the Journal of Chemical Information and Modeling , Molecular Biology of the Cell , and Chemical Research in Toxicology. Molecular Biology of the Cell. A fourth is in the works. DOI: 10.1021/acs.chemrestox.4c00015. Seal S, et al.
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Nucleic acid therapy accelerator
Drug Target Review
NOVEMBER 23, 2023
About the author Dr William Schafer Group Leader at MRC Laboratory of Molecular Biology William Schafer is a neuroscientist who has investigated conserved principles by which neurons and neural circuits control behaviour.
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Empowering scientists in the genomic revolution
sptlabtech
JUNE 9, 2023
However, with so many individual processes involved in NGS library preparation, you might think that automating this workflow requires several instruments costing large amounts of laboratory space. Enter firefly ®. What benefits can you expect to see from making the switch to automated liquid handling with firefly?
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The history – and the future – of antibody discovery technologies
DrugBaron
FEBRUARY 16, 2021
The first technological leap was the invention of hybridoma technology, by César Milstein together with his post-doc Georges Köhler working at the world-famous Laboratory of Molecular Biology in Cambridge.
Women in Stem with Dr Beate Mueller-Tiemann
Drug Target Review
FEBRUARY 19, 2024
I always found science fascinating, but I really fell in love with it in high school when I was introduced to biochemistry and molecular biology. Biochemistry and molecular biology fascinated me in school. Can you tell us about your journey in the field of STEM and the challenges you encountered along the way?
Samuel DePalma
Broad Institute
OCTOBER 24, 2024
Samuel DePalma By admin October 24, 2024 Samuel DePalma Research Scientist I Sam DePalma is a Research Scientist I in the Precision Cardiology Laboratory (PCL) of Bayer and the Broad Institute. Prior to joining Bayer and the PCL, DePalma earned his Ph.D.
Broad-MIT Seminars in Chemical Biology: Phil Holliger
Broad Institute
FEBRUARY 24, 2025
Broad-MIT Seminars in Chemical Biology: Phil Holliger By Rose Circeo February 24, 2025 Breadcrumb Home Broad-MIT Seminars in Chemical Biology: Phil Holliger Broad-MIT Seminars in Chemical Biology February 24, 2025 Broad Institute of MIT and Harvard Speaker: Phil Holliger, MRC Laboratory of Molecular Biology Talk title: Replicating RNA with RNA Description: (..)
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Liquid Handling - Empowering scientists in the genomic revolution
sptlabtech
JUNE 9, 2023
However, with so many individual processes involved in NGS library preparation, you might think that automating this workflow requires several instruments costing large amounts of laboratory space.
F. William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines
Broad Institute
OCTOBER 16, 2024
William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. It’s changing the world.”
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The essential role of recombinant phage display antibody libraries
Drug Target Review
OCTOBER 3, 2024
Moreover, ethical considerations regarding the use of laboratory animals further complicate the use of primate polyclonal serum, and successful immunisation is not always guaranteed. Methods in Molecular Biology. Journal of Molecular Biology. 2021;291–306. Prassler J, Thiel S, Pracht C, et al.
A how-to for performing quantitative bioimaging
Broad Institute
JULY 13, 2023
Funding Support for this work was provided by the National Institutes of Health, the Chan Zuckerberg Initiative DAF through the Silicon Valley Community Foundation, the European Molecular Biology Laboratory, and a Morgridge Postdoctoral Fellowship.
Phages could help to tackle antimicrobial resistance
Drug Target Review
DECEMBER 7, 2023
Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. He continued: “CBASS cyclases look a lot like cGAS, so they have to be sensing something.
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Q&A With Dr. Norbert Makori and Pierre Jolicoeur: The Benefits of Combining Preclinical and Bioanalytical for Your Gene Therapy Studies
Alta Sciences
MARCH 1, 2024
PJ: At Altasciences, we have a range of leading-edge platforms that include ligand binding assays (LBA), NAb, TAb, flow cytometry, and ELISpot, as well as on-site molecular biology instrumentation such as Bio-Rad’s ddPCR system, the NanoDropTM One spectrophotometer, and dedicated polymerase chain reaction (PCR) chambers.
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Chinese Government Arrests GenScript and Legend Biotech Founder for Smuggling
The Pharma Data
NOVEMBER 23, 2020
Before joining GenScript, Zhu worked at California-based Clontech Laboratories, Inc. as a director of molecular biology. Li Zhu, chief strategy officer at GenScript Biotech, was tapped to fill Zhang’s place on the board. Zhu founded Genetastix Corporation, Inc.,
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Internships at Altasciences: Q&A With Our Summer Interns
Alta Sciences
AUGUST 21, 2024
I have also learned a lot about the nuances of micropipettes that I would have never learned at school.” — Sheridan Moore , Research Associate Intern, Laboratory Sciences “My favorite part about interning at Altasciences is the potential for creating a long, meaningful career that I would be passionate about.
Trends & Insights: Spotlight Winter Edition
DrugBank
FEBRUARY 9, 2023
Check out previous Trends & Insights Spotlights Academic User Spotlight Subhajit Dutta 1,2 & Ted Natoli 3 Laboratory of Cellular Differentiation & Metabolic Disorder, Department of Biotechnology, National Institute of Technology Durgapur, India. 2 Cancer Program, Broad Institute of MIT and Harvard, USA.
AstraZeneca unveils The Discovery Centre (DISC) in Cambridge
The Pharma Data
NOVEMBER 22, 2021
Located within the Cambridge Biomedical Campus1, the physical propinquity of the structure’s m2 laboratories to leading hospitals, the University of Cambridge, other exploration institutions and a number of biotech companies will promote a culture of open cooperation and invention in its inviting open spaces.
Bristol Myers Squibb Awards “Golden Tickets” to Promising Biotechs for Residencies at LabCentral, Biolabs@NYULangone and MBC BioLabsf
The Pharma Data
NOVEMBER 18, 2021
LabCentral offers completely permitted laboratory and office space for as numerous as 70 startups comprising roughly 500 scientists and entrepreneurs. Each point has a complete molecular biology core installation that allows companies to do trials on day one. For further information, visitwww.labcentral.org or Twitter.
Code breaking and the Human Genome Project
The Open Targets Blog
APRIL 25, 2023
Although the estate was undoubtedly pretty, the Hall had seen better days and was rather dominated by a 1950s building that provided laboratories for the light engineering company that had owned the site. For the genome sequencing at the Sanger Centre, we also brought together diverse people to achieve our goals.
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Using AI to predict metastatic behaviour of NSCLC
Drug Target Review
APRIL 8, 2024
Dr Govindan is keen on translating genomic discoveries from the laboratory setting to clinical setting to improve the outcomes of patients with lung cancer and mentor trainees and junior faculty members. Chair of the Department of Pathology and Professor of Biochemistry and Molecular Biology. In 2009, he became the Joseph R.
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CytoDel Announces Pre-Clinical Data on Cyto-111 as Antidote to Botulinum Neurotoxin (BoNT) Published in Science Translational Medicine
The Pharma Data
JANUARY 6, 2021
Cyto-111 was conceived, expressed and purified in the laboratory of Konstantin Ichtchenko, Ph.D., About CytoDel CytoDel is a privately held biopharmaceutical company that uses the tools of 21st century molecular biology to produce recombinant derivatives of botulinum neurotoxin customized to specific applications.
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Sosei Heptares’ COVID-19 Program Identifies Potent Broad Spectrum Anti-Viral Small Molecules for Further Development
The Pharma Data
NOVEMBER 19, 2020
The program is being led by Sosei Heptares and progressed in collaboration with multiple companies including Syngene International, Domainex, Fidelta, o2h Discovery, Piramal, WuXi AppTec and the MRC Laboratory of Molecular Biology.
Meet the Flower Designer Who Built a Laboratory In His Home
Codon
JULY 17, 2024
In a quiet New York town, an amateur scientist has constructed a fully equipped research laboratory in which to advance plant biology research. ” Earlier this year, we sent a photographer to Sebastian’s home laboratory. ” Earlier this year, we sent a photographer to Sebastian’s home laboratory.
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Inside the Laboratory for Extraordinary Microbes
Codon
JULY 10, 2024
But in the 1950s, at the dawn of molecular biology, scientists gained a new appreciation for it after searching for organisms that were easy to work with and quick to grow. 1 This singular organism has become the de facto microbe for molecular biology. Lee showed me around the laboratories on a clear day in April.
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Breaking the Speed Limit on Cell Division
Codon
JUNE 25, 2024
So-called primary cells, harvested from living tissues and cultured in the laboratory, can take weeks to grow and spread across a culture flask, hampered partly by their large genomes, which take time to copy. As novel speed adaptations accumulate in laboratory cultures, researchers can cherry-pick bacteria that divide faster.
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Repurposing FDA-approved drugs may help combat COVID-19
The Pharma Data
FEBRUARY 25, 2022
. “The SARS-CoV-2 vaccines target the spike protein, but this protein is under strong selection pressure and, as we have seen with Omicron, can undergo significant mutations,” said Joyce Jose, assistant professor of biochemistry and molecular biology, Penn State. 25) in the journal Communications Biology.
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2021 Hansen Family Award goes to Professor Kai Johnsson
The Pharma Data
MARCH 16, 2022
As Professor Patrick Cramer, Professor at the Max-Planck Institute for Multidisciplinary Sciences and Director of the Molecular Biology Department, emphasized in his congratulatory speech: “Kai Johnsson is a world-leading research scientist in chemical biology.
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The Promise of Gas Vesicles
Codon
JUNE 18, 2024
These algae are “one of the most interesting, at least one of the most striking, of the plankton,” wrote Klebahn, who transported the cells back to his laboratory in Hamburg, one hundred kilometers to the south. Light and Sound Progress in biology has long been driven by light. ” During his Ph.D., up to 17 MHz.
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A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic
Broad Institute
APRIL 25, 2024
The project is a collaboration between the Broad and the African Center of Excellence for Genomics of Infectious Diseases (ACEGID) at Redeemer’s University outside Lagos in Nigeria, where Happi is a professor of molecular biology and genomics. Rural clinics use rapid, low-cost tests to detect a few common pathogens.
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Roche launches new quantitative antibody test to measure SARS-CoV-2 antibodies, to support the evaluation of vaccines
The Pharma Data
SEPTEMBER 17, 2020
The test is the latest addition to the comprehensive Roche diagnostic portfolio to help healthcare systems combat COVID-19 through testing in the laboratory and at the point of care. Hospitals and reference laboratories can run the test on Roche’s cobas e analyzers which are widely available around the world. Academic Press.
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Synthetic Origins
Codon
APRIL 2, 2024
But in those early years, everything in the laboratory was so slow and difficult. I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits.
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Study offers insights on why the elderly are more susceptible to COVID-19
The Pharma Data
NOVEMBER 9, 2021
Elias is part of a National Institutes of Health-funded laboratory that focuses on the cell and molecular biology of lung injury and repair.
Merkin Prize in Biomedical Technology awarded to F. William Studier for development of widely used protein- and RNA-production platform
Broad Institute
MAY 14, 2024
William Studier for development of widely used protein- and RNA-production platform The $400,000 award recognizes the far-reaching medical impacts of Studier’s development, in the 1980s, of an efficient and scalable technology to produce mass amounts of RNA and proteins in laboratories that is widely used today all over the world.
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Alpaca nanobodies potently neutralize SARS-CoV-2 variants
The Pharma Data
MARCH 25, 2022
“With the help of advanced laboratory techniques, we were able to identify a panel of nanobodies that very effectively neutralized several variants of SARS-CoV-2,” says Gerald McInerney, professor at the Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, and joint senior author of both studies.
Measure Cell Metabolism with Microplate Readers | BMG LABTECH
BMG Labtech
MARCH 8, 2023
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press. Alberts B, How Cells Obtain Energy from Food, Molecular Biology of the Cell (4th ed.). Alberts B, 2002, Energy Conversion: Mitochondria and Chloroplasts, Molecular Biology of the Cell (4th ed.). doi:10.1101/glycobiology.3e.005 PMID 28876856. PMC 1456893.
What is the largest CRO in the US?
Vial
MARCH 1, 2024
billion in 2023 attributable to its laboratory products and biopharma services segment (53.8% By type of service, clinical research services accounted for the lion’s share of the North American CRO services market, followed by early-phase development services, laboratory services, and consulting services. of total revenue).
Forty of the Nation’s Most Talented Young Scientists Named Finalists in Regeneron Science Talent Search 2021
The Pharma Data
JANUARY 21, 2021
Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to eight FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories.
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Optimizing your ELISA Assays | BMG LABTECH
BMG Labtech
MARCH 11, 2024
Enzyme-Linked Immunosorbent Assays (ELISAs) are an essential technique in today’s laboratory with many applications in the life sciences. 1,2 Anton Schuurs and Bauke van Weemen at the research laboratories of NV Organon, Oss, the Netherlands developed a similar technique which was also published in 1971.
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Codon Digest: Seeing Colors After Gene Therapy
Codon
JULY 27, 2023
.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. A YouTuber, The Thought Emporium , is growing rat neurons in the laboratory.
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Codon Digest: Seeing Colors After Gene Therapy
Codon
JULY 27, 2023
.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. A YouTuber, The Thought Emporium , is growing rat neurons in the laboratory.
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Codon Digest: Hackathon Prize Winners
Codon
JUNE 26, 2023
This reminds me of the Chemputer , “an autonomous compiler and robotic laboratory platform to synthesize organic compounds on the basis of standardized methods descriptions,” that was reported back in 2019. “Anyone with a few years of molecular biology training could do this if so inclined.”
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