Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

Bioinformatics 287

Bioinformatics Pharmacogenetics RNA Medical Schools 287

Codon

APRIL 2, 2024

But in those early years, everything in the laboratory was so slow and difficult. I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits.

RNA 56

RNA Engineering Molecular Biology Synthetic Chemistry 56

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It is the untouchable foundation of molecular biology. This is simple.

RNA 64

RNA DNA Engineering Laboratories 64

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It is the untouchable foundation of molecular biology. This is simple.

RNA 52

RNA DNA Engineering Laboratories 52

Codon

JUNE 25, 2024

So-called primary cells, harvested from living tissues and cultured in the laboratory, can take weeks to grow and spread across a culture flask, hampered partly by their large genomes, which take time to copy. Proteins are colored blue and RNA molecules are colored orange and yellow. The large and small ribosome subunits.

DNA 70

DNA RNA Laboratories Engineering 70

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Broad Institute

JANUARY 30, 2024

He spent many school breaks at Argonne National Laboratory where his parents both worked as scientists. His advisor marched him down to the office of a new faculty member, Tobin Sosnick, who is now chair of the Department of Biochemistry and Molecular Biology at the University of Chicago.

Hospitals 137

Hospitals Medical Schools Virus Science 137

Drug Discovery World

NOVEMBER 15, 2022

Although simple in its concept, the method itself is highly involved and requires the use of hazardous, unstable chemicals, making the whole ordeal labour-intensive and cost-prohibitive for individual laboratories to synthesise DNA sequences on their own.

DNA 246

DNA Engineering Drugs Vaccine 246

Codon

JULY 10, 2024

But in the 1950s, at the dawn of molecular biology, scientists gained a new appreciation for it after searching for organisms that were easy to work with and quick to grow. 1 This singular organism has become the de facto microbe for molecular biology. Lee showed me around the laboratories on a clear day in April.

Laboratories 76

Laboratories DNA Molecular Biology Engineering 76

Codon

JUNE 26, 2023

This reminds me of the Chemputer , “an autonomous compiler and robotic laboratory platform to synthesize organic compounds on the basis of standardized methods descriptions,” that was reported back in 2019. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. Paper by Sha G. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

This reminds me of the Chemputer , “an autonomous compiler and robotic laboratory platform to synthesize organic compounds on the basis of standardized methods descriptions,” that was reported back in 2019. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. Paper by Sha G. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52