Laboratories Packaging RNA 
Broad Institute
JUNE 27, 2024
CRISPRoff silences the targeted gene by adding methyl groups, chemical tags that prevent the gene from being transcribed or read into RNA and so from being expressed as protein. The first problem they had to tackle was the editor’s size, because the editor needs to be small enough to be packaged and delivered to specific cells in the body.
The Pharma Data
OCTOBER 19, 2020
Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. Photo: Business Wire).
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Codon
JULY 27, 2023
A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?
Codon
JULY 27, 2023
A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?
Codon
APRIL 2, 2023
A giant dataset about the rat brain, and how neurons connect to each other, was collected and pooled together from 20 different research laboratories. Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). Nature Neuroscience. Gene Therapy.
Codon
APRIL 2, 2024
But in those early years, everything in the laboratory was so slow and difficult. AP: We can’t even grow most types of cells in the laboratory. The RNA Exporter , which was developed by Felix Horns and others in my lab, is one example. The exported RNA could transfect just the target cell. Elowitz: Exactly.
The Pharma Data
JANUARY 17, 2021
It received FDA guidance January 5 th and is in the midst of preparing the first package of investigational new drug (IND) applications – usually with an n-of-1, for individual patients. That’s not the case with RNA-targeted drugs. Patient dosing is expected to begin later this year. “No
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