Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. However, with a strong therapy design and promising laboratory results in hand, the researchers have good reason to be hopeful.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Drug Target Review

FEBRUARY 19, 2024

I did my PhD project on elucidating the role of the p53 protein that is relevant in many cancers. In the early 1990’s we did not fully understand what this protein was and how it worked. This made significant impact on accelerating lead discovery in the pharmaceutical industry.

Molecular Biology 110

Molecular Biology Science Protein Expression Production 110

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

Learn how Strateos’ automated synthetic biology modules supported rapid, iterative screening of RNA sequences in modular pbuE expression system and E. coli extract-based cell-free protein expression assays.

Engineering 52

Engineering Protein Expression Research Laboratories RNA 52

Drug Target Review

JULY 5, 2023

This selectable marker enables the identification of cells which have taken up the GOIs and aids the initial selection of recombinant protein expressing cell lines. However, some groups will decide to complete this stage within their own laboratories. We talk about personalised medicine; how about personalised host cell lines?

Engineering 105

Engineering DNA Laboratories Production 105

Elrig

JUNE 13, 2024

Protein Sciences in Drug Discovery 2024 takes place from 1819 November at Hinxton Hall Conference Centre in Cambridge, UK.

Science 52

Science Protein Expression Drugs International 52

Conversations in Drug Development Trends

AUGUST 14, 2024

Proteomics Proteomics involves studying the entire set of proteins expressed in a cell or tissue. While biomarkers must undergo rigorous validation and regulatory processes, it’s important to ensure the methods for biomarker testing are consistent and accurate across different laboratories and clinical settings.

Treatment 78

Treatment Therapies Disease Protein Expression 78

Drug Target Review

SEPTEMBER 4, 2023

10 Reported cAMP as the second messenger signalling molecule conserved from bacteria to humans and modulates several biological processes, including protein expression, gene transcription, and cell development and differentiation. He has over two years of experience in research and laboratory work.

Drugs 111

Drugs RNA DNA Disease 111

Broad Institute

AUGUST 24, 2022

The team then conducted analyses that triangulated treatment response, chromosomal deletion or gain, and concordant decreases or increases in mRNA and protein expression. Of the hundreds of genes deleted in this location, the DNA ligase gene LIG1 was one of the mostly consistently suppressed genes at both the mRNA and protein level.

DNA 52

DNA Protein Expression Treatment Protein Production 52

Drug Target Review

SEPTEMBER 10, 2024

However, developing an accelerated IND application requires that good laboratory practice (GLP) toxicological data must be generated, collected, interpreted and integrated in the IND-enabling data package. Novel vector design and synthetic promoters have been designed to maximise productivity and enhance gene expression stability.

Drug Development 64

Drug Development Clinical Supply Production FDA 64

The Pharma Data

JANUARY 13, 2021

said, “Nearly 30 years ago my laboratory at Columbia University generated the first anti-CD40-ligand mAb (5c8), discovered and characterized human CD40-ligand and elucidated the molecular basis of T cell helper function 1. CD40-ligand is a protein expressed on the surface of activated T lymphocytes that mediates T cell helper function.

Pharmaceuticals 52

Pharmaceuticals Small Molecule Vaccine Protein Expression 52

Broad Institute

OCTOBER 4, 2023

In this case the prize is designed to honor not just technologies that are exciting in the laboratory but technologies that have had an impact on public health and clinical care.” Wang concluded her presentation by expressing gratitude to Merkin. Yet we all know as scientists that it’s technology that drives discovery.

DNA 52

DNA RNA Science Protein Expression 52

The Pharma Data

JANUARY 13, 2021

based Mogrify Limited expanded its research collaboration with MRC Laboratory of Molecular Biology. The project aims to develop novel protein expression systems by leveraging recent advances in direct cell reprogramming to help improve the production of proteins which are not produced sufficiently well in existing expression systems.

Licensing 52

Licensing Licensing Clinical Trials Trials 52

The Pharma Data

JANUARY 15, 2021

3 HER2 is a tyrosine kinase receptor growth-promoting protein expressed on the surface of many types of tumors including breast, gastric, lung and colorectal cancer. The safety of Enhertu was evaluated in 187 patients with locally advanced or metastatic HER2 positive gastric or GEJ adenocarcinoma in DESTINY-Gastric01. 2,5 In the U.S.,

Treatment 52

Treatment Trials Disease Therapies 52

Codon

APRIL 9, 2023

Marine sponges were cultured in the laboratory continuously for the first time. AI + Bio *Transfer learning for cross-context prediction of protein expression from 5’UTR sequence. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. Biology is the world’s most advanced technology.

Therapies 52

Therapies RNA Engineering Vaccine 52

The Pharma Data

OCTOBER 26, 2020

Increased infiltrates, expression of immune related genes and higher PD-L1 protein expression were observed across all patients suggesting a remodeling of the tumor microenvironment consistent with a switch toward a “hot tumor” phenotype. Conclusions.

Vaccine 40

Vaccine Trials Treatment Virus 40