Drug Discovery World

FEBRUARY 6, 2024

Scientific sessions Tuesday’s presentations spanned a range of topics, including functional genomics for target identification, next-generation proteomics, self-driving laboratories, the future of cell culture, and ‘lab on a particle’ technology. The post SLAS2024: Day Two Highlights appeared first on Drug Discovery World (DDW).

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RNA Laboratories Science Vaccine 162

Broad Institute

JUNE 18, 2024

By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples. Then, in 2022, they began adapting the assay to detect other viruses they knew were always circulating: influenzas.

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Virus RNA Medical Schools Laboratories 143

Drug Discovery World

MARCH 3, 2023

SiSaf will develop miRNA Bio-Courier formulations that will be tested in pancreatic cancer models in Professor Aigner’s laboratory. Under the terms of the agreement SiSaf has an exclusive option to acquire a worldwide license to a patent by the University.

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RNA Clinical Pharmacology Regulations Licensing 130

Drug Discovery World

NOVEMBER 1, 2022

He published ‘maps” depicting how various cell types use alternative splicing of messenger RNA to construct genetic templates that produce an ever-changing set of proteins in the cell. . In human ocular melanomas cultured in the laboratory, the scientists delivered SLED packages into only melanoma cells that lack the SF3B1 gene.

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Packaging RNA Laboratories Therapies 130

Drug Target Review

JANUARY 2, 2024

Forging the toolkit for subcellular omics Cellular components known as organelles, consisting of RNA and protein, exert vital influences on human wellbeing and ailments by sustaining equilibrium, managing growth and ageing, and producing energy.

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RNA Immune Response Therapies Disease 128

Drug Discovery World

FEBRUARY 6, 2023

A case in point is the emerging omics and other high-throughput laboratory technologies that allow simultaneous profiling of genetic alterations in combination with profiling thousands of molecules in plasma, cell populations, or single cells. It also helps to quickly address unplanned changes.

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Bioinformatics RNA Vaccine Clinical Trials 130

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

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Bioinformatics Pharmacogenetics RNA Medical Schools 287

Drug Target Review

JULY 24, 2023

Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The initial subject of my research carrier was RNA polymerase principal sigma factors in bacteria. The first identification was based on a bioinformatic analysis.

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RNA Regulations Bioinformatics Laboratories 98

Drug Discovery World

OCTOBER 28, 2022

New research suggests messenger RNA can be effectively used as a ‘universal’ therapy against different coronaviruses. . A panel of investigational monoclonal antibodies (mAbs) targeting different sites of the Epstein-Barr virus (EBV) have been shown to block infection when tested in human cells in a laboratory setting. . .

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Virus RNA Drugs Laboratories 130

Drug Discovery World

JANUARY 26, 2023

The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells. Provided by Sophia Kolesnikova of the Laboratory of Marine Natural Compounds Chemistry at the GB Elyakov Pacific Institute of Bioorganic Chemistry.

Organic Chemistry 130

Organic Chemistry Laboratories RNA DNA 130

Drug Discovery World

JULY 18, 2023

Nucleic acid-based diagnostics, which typically require PCR reagents and laboratory equipment, are crucial for identifying, treating, and preventing common infectious diseases. CRISPR diagnostics have successfully detected various pathogens, including RNA viruses (eg. Herpesviridae, Polyomaviridae, and Papillomaviridae), bacteria (e.g.,

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Disease DNA RNA Therapies 246

Codon

JUNE 25, 2024

So-called primary cells, harvested from living tissues and cultured in the laboratory, can take weeks to grow and spread across a culture flask, hampered partly by their large genomes, which take time to copy. Proteins are colored blue and RNA molecules are colored orange and yellow. The large and small ribosome subunits.

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DNA RNA Laboratories Engineering 97

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

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RNA Immune Response DNA Molecular Biology 58

PLOS: DNA Science

MAY 16, 2024

That’s thanks to accelerated genome sequencing technologies, expanded laboratory capabilities, and interacting infrastructure on a global level. As soon as the initial RNA genome sequence of the pathogen that would be named SARS-CoV-2 was published, CDC and other organizations began developing diagnostic tests.

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Virus DNA RNA Laboratories 82

Drug Discovery World

JULY 2, 2024

Superlab Suisse, a provider of laboratory and research spaces, is a great example of this mix of regionality and reproducibility. This also means there is no shortage of skilled workers thanks to the universities and the well-established apprenticeship system, for example, in the field of biology laboratory technicians.

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Science Drugs Clinical Trials Licensing 147

Alta Sciences

APRIL 16, 2024

Gene therapy requires DNA and/or RNA delivery and analysis, and while most ongoing research involves therapies being delivered in vivo via adeno-associated viral (AAV) vectors, other in vivo delivery methods are on the rise. This ability to analyze variation from limited samples has made genetic diagnosis easier than ever.

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Therapies DNA RNA Laboratories 52

Drug Discovery World

APRIL 11, 2023

The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells.

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Drug Research Research Drugs RNA 130

Drug Discovery World

AUGUST 1, 2022

Chief of the Virus Persistence and Dynamics Section in the VRC Laboratory of Immunology, described NIAID’s long-standing collaboration with a bioengineering research group at the University of California, San Francisco. In the presentation, Eli Boritz, M.D.,

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Virus RNA DNA Therapies 130

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. Blueprints The first step is to build a loop of RNA that encodes all the different codons.

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RNA DNA Engineering Laboratories 75

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

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DNA Engineering RNA Laboratories 145

Broad Institute

JUNE 28, 2023

Today, scientists use these reactions to produce customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and many aspects of basic biomedical research. “I Longer synthetic DNA and RNA molecules are also critical for modern biologic drugs.

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DNA RNA Science Therapies 98

Drug Discovery World

JULY 26, 2022

Pharmaceutical company BioNTech will deliver the 2022 César Milstein Lecture on 26 July with a focus on how messenger RNA (mRNA) technology can be used within vaccines for cancer and Covid-19. . The César Milstein Lecture is named in honour of the MRC Laboratory of Molecular Biology (LMB) LMB Nobel Laureate César Milstein.

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Vaccine Immune Response Molecular Biology RNA 130

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. Blueprints The first step is to build a loop of RNA that encodes all the different codons.

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RNA DNA Engineering Laboratories 52

Drug Target Review

APRIL 9, 2024

In a previous study, we showed that these peptides decorate all cellular RNAs and thus impair the binding of RNA-binding proteins to RNA. Today, several companies have ATR inhibitors at various stages of clinical development, which to a significant extent was influenced by early works from the laboratory.

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RNA Cell Biology Clinical Development DNA 63

Drug Discovery World

JANUARY 4, 2023

They found that neutralising several distinct immunosuppressive mechanisms of the tumour immune microenvironment (TIME) dramatically improved survival rates in laboratory models, pointing to a potential treatment option for this notoriously lethal and unresponsive cancer. . Details of the study .

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Immune Response Therapies RNA Clinical Trials 130

Drug Discovery World

AUGUST 8, 2023

Outside of academia, there are institutions such as the CSIR- Central Drug Research Institute (CDRI), a multidisciplinary research laboratory in Lucknow 11. It is India’s largest multi-tenanted lab space infrastructure cluster in a single location, with the addition of over 250,000 sq ft of laboratory space annually 12.

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Research Pharmacy Pharmaceuticals Government 130

Alta Sciences

MARCH 1, 2024

The new cells are then grown in high numbers in a laboratory and then are re-administered to the patient, where the genetically modified cells will attack more specific cancer cells. This technology extensively utilizes immunofluorescence and flow cytometry technology, which is a platform offered in our laboratories.

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Drug Discovery World

NOVEMBER 7, 2022

7 The collaboration will see Children’s Mercy Kansas City use PacBio’s Sequel IIe system in the study of genetic disease and the research will apply direct methylation detection and Iso-Seq full-length RNA sequencing.

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Therapies DNA Disease Research 246

Drug Discovery World

MARCH 13, 2024

Sanofi is also building a facility there, one of two fully digitised vaccine manufacturing EVolutive Facilities (EVF), capable of producing up to four vaccines at the same time, along with Hilleman Laboratories, which has recently opened a US$20 million vaccine manufacturing plant. We are small and integrated.

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Government Science Pharmaceuticals Vaccine 173

The Pharma Data

FEBRUARY 12, 2022

The primary study endpoints are the proportion of actors passing treatment-imperative adverse events; proportion of actors passing treatment-emergent graded laboratory abnormalities; and tube attention of remdesivir and metabolites, independently.

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Pharmacokinetics RNA Hospitals Laboratories 52

KIF1A

MAY 4, 2024

Later, she developed an interest in the RNA world, specifically focusing on alternative splicing and its correlation with neuron cell properties within and across cell types. During her undergraduate studies, she worked on heart disease research in Chi Kueng Lam’s laboratory at the University of Delaware.

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Science Medical Schools RNA Research 116

The Pharma Data

DECEMBER 10, 2020

Unsupervised use of this technique by people without medical training can lead to transmission of pathogens, according to Paul Carlson, principal investigator in the Laboratory of Mucosal Pathogens and Cellular Immunology at FDA’s Office of Vaccines Research and Review. 1, 2019, until effective screening methods are implemented.”.

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FDA Laboratories RNA Virus 52

The Pharma Data

MARCH 20, 2021

As laboratories around the world tackle the challenges of screening large numbers of samples for SARS-CoV-2, the managers of these labs have turned to the use of automation to address some key concerns. As there are fewer steps carried out by hand this reduces potential exposure for laboratory staff as well. In the examples below, we.

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Laboratories Virus RNA Bioinformatics 52

Drug Target Review

SEPTEMBER 4, 2023

I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. He has over two years of experience in research and laboratory work. We were part of a team that studies the efficacy of garlic (Allium sativum) against the Cowpea Weevil Callosobrocus maculatus.

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Drugs RNA DNA Disease 110

Drug Target Review

FEBRUARY 6, 2024

Advances in DNA and RNA-focused molecular diagnostic methods have made blood-based multi-cancer early detection (MCED) tests a reality, but not for all patients. His more than 30 years of experience ranges from start-ups such as Exact Sciences and Good Start Genetics to established multinationals such as Abbott Laboratories.

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DNA RNA Science Laboratories 105

Drug Target Review

FEBRUARY 5, 2024

Adult laboratory mice heal injuries with scar tissue, but spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body. It also showed that increasing and maintaining this type of signalling in laboratory mice could initiate a regenerative response instead of scarring.

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Laboratories Immune Response Regulations RNA 58

The Pharma Data

SEPTEMBER 1, 2021

Study Now Enrolling Participants Who Live in the Same Household as Someone With Symptomatic, Laboratory-Confirmed COVID-19. The global study is enrolling individuals who are at least 18 years of age and reside in the same household as someone with laboratory-confirmed SARS-CoV-2 infection with symptoms. MOVe-AHEAD Study.

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Laboratories Virus Clinical Trials Research Laboratories 52