Drug Target Review

JULY 24, 2023

Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The initial subject of my research carrier was RNA polymerase principal sigma factors in bacteria. The first identification was based on a bioinformatic analysis.

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

DNA 145

DNA RNA Engineering Laboratories 145

Broad Institute

OCTOBER 23, 2024

What is special about these synthetically designed elements is that they show remarkable specificity to the target cell type they were designed for," said Ryan Tewhey, an associate professor at The Jackson Laboratory and co-senior author of the work with Steven Reilly of Yale, and Pardis Sabeti of the Broad.

Research 136

Research DNA Laboratories Molecular Biology 136

Codon

AUGUST 26, 2024

Brian Wang (co-founder of the nonprofit Panoplia Laboratories ) outlines his approach to making broad-spectrum antivirals. Last year, several colleagues and I joined these efforts by co-founding Panoplia Laboratories , a nonprofit organization developing broad-spectrum antivirals using tools from synthetic biology.

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RNA Virus DNA Vaccine 85

PLOS: DNA Science

MAY 16, 2024

That’s thanks to accelerated genome sequencing technologies, expanded laboratory capabilities, and interacting infrastructure on a global level. As soon as the initial RNA genome sequence of the pathogen that would be named SARS-CoV-2 was published, CDC and other organizations began developing diagnostic tests.

Virus 97

Virus DNA RNA Laboratories 97

Broad Institute

JUNE 28, 2023

Today, scientists use these reactions to produce customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and many aspects of basic biomedical research. “I Longer synthetic DNA and RNA molecules are also critical for modern biologic drugs.

DNA 98

DNA RNA Science Therapies 98

Broad Institute

OCTOBER 16, 2024

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

Vaccine 64

Vaccine RNA Laboratories Molecular Biology 64

Broad Institute

OCTOBER 17, 2024

The method, called Genotypic and Phenotypic Antibiotic Susceptibility Testing through RNA detection, or GoPhAST-R, analyzes the growth and genetic activity of the bacteria to quickly determine the pathogen’s susceptibility to various medicines.

RNA 69

RNA Hospitals Laboratories Medical Schools 69

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

RNA 99

RNA DNA Vaccine Virus 99

Broad Institute

AUGUST 19, 2024

Jude Children’s Research Hospital have discovered that oleic acid, one of the most abundant fatty acids in the body, restores a healthy balance of vaginal microbes in a laboratory model of BV. Using RNA sequencing and working with the Broad’s Metabolomics Platform and collaborators at St.

Hospitals 121

Hospitals Treatment Medical Schools Science 121

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

RNA 59

RNA Immune Response DNA Molecular Biology 59

Drug Target Review

AUGUST 28, 2024

We then incubate the cells to mature into ‘pro-regenerative’ macrophages and insert two RNA messages to produce two human proteins that will be expressed at the site of injury when these ‘engineered’ macrophages are given back to the patient. The patient’s own monocytes, a type of white blood cell, are removed via an apheresis procedure.

Therapies 116

Therapies Disease Engineering Medical Schools 116

Drug Target Review

SEPTEMBER 4, 2023

I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. He has over two years of experience in research and laboratory work. We were part of a team that studies the efficacy of garlic (Allium sativum) against the Cowpea Weevil Callosobrocus maculatus.

Drugs 111

Drugs RNA DNA Disease 111

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. Blueprints The first step is to build a loop of RNA that encodes all the different codons.

RNA 63

RNA DNA Engineering Laboratories 63

KIF1A

MAY 4, 2024

Later, she developed an interest in the RNA world, specifically focusing on alternative splicing and its correlation with neuron cell properties within and across cell types. During her undergraduate studies, she worked on heart disease research in Chi Kueng Lam’s laboratory at the University of Delaware.

Science 116

Science Medical Schools RNA Research 116

Drug Target Review

FEBRUARY 6, 2024

Advances in DNA and RNA-focused molecular diagnostic methods have made blood-based multi-cancer early detection (MCED) tests a reality, but not for all patients. His more than 30 years of experience ranges from start-ups such as Exact Sciences and Good Start Genetics to established multinationals such as Abbott Laboratories.

DNA 105

DNA RNA Science Laboratories 105

Broad Institute

SEPTEMBER 28, 2023

By Allessandra DiCorato September 28, 2023 Credit: Strittmatter Laboratory, Yale University Amyloid beta clusters (red) builds up among neurons (green) in a mouse model of Alzheimer’s disease. Macosko knew samples from these living patients presented a rare chance to observe cells exposed to the initial stages of Alzheimer’s pathology.

Disease 144

Disease Medical Schools Research Hospitals 144

Codon

AUGUST 27, 2024

When doctors sequenced the DNA and RNA found in Alice’s blood and synovial fluid—the liquid that surrounds and lubricates joints—they found abnormally low levels of genes encoding iron-storing proteins and high levels of epidermal growth factor receptor RNA. At least nine laboratories outside the U.S.

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DNA Laboratories Hospitals Virus 84

The Pharma Data

DECEMBER 10, 2020

Unsupervised use of this technique by people without medical training can lead to transmission of pathogens, according to Paul Carlson, principal investigator in the Laboratory of Mucosal Pathogens and Cellular Immunology at FDA’s Office of Vaccines Research and Review. 1, 2019, until effective screening methods are implemented.”.

FDA 52

FDA Laboratories RNA Virus 52

Alta Sciences

APRIL 16, 2024

Gene therapy requires DNA and/or RNA delivery and analysis, and while most ongoing research involves therapies being delivered in vivo via adeno-associated viral (AAV) vectors, other in vivo delivery methods are on the rise. This ability to analyze variation from limited samples has made genetic diagnosis easier than ever.

Therapies 52

Therapies DNA RNA Laboratories 52

Drug Target Review

APRIL 9, 2024

In a previous study, we showed that these peptides decorate all cellular RNAs and thus impair the binding of RNA-binding proteins to RNA. Today, several companies have ATR inhibitors at various stages of clinical development, which to a significant extent was influenced by early works from the laboratory.

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RNA Cell Biology Clinical Development DNA 64

The Pharma Data

MARCH 20, 2021

As laboratories around the world tackle the challenges of screening large numbers of samples for SARS-CoV-2, the managers of these labs have turned to the use of automation to address some key concerns. As there are fewer steps carried out by hand this reduces potential exposure for laboratory staff as well. In the examples below, we.

Laboratories 52

Laboratories Virus RNA Bioinformatics 52

Codon

JUNE 25, 2024

So-called primary cells, harvested from living tissues and cultured in the laboratory, can take weeks to grow and spread across a culture flask, hampered partly by their large genomes, which take time to copy. Proteins are colored blue and RNA molecules are colored orange and yellow. The large and small ribosome subunits.

DNA 69

DNA RNA Laboratories Research 69

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. Blueprints The first step is to build a loop of RNA that encodes all the different codons.

RNA 52

RNA DNA Engineering Laboratories 52

The Pharma Data

FEBRUARY 12, 2022

The primary study endpoints are the proportion of actors passing treatment-imperative adverse events; proportion of actors passing treatment-emergent graded laboratory abnormalities; and tube attention of remdesivir and metabolites, independently.

Pharmacokinetics 52

Pharmacokinetics RNA Hospitals Laboratories 52

Drug Target Review

AUGUST 30, 2023

We can test their viability in the population, speeding up discovery and saving resources associated with laboratory target validation. 1 Targets were then further validated by combining testing the most promising drug candidates and knocking down specific targets using short interfering RNA (siRNA) and antisense oligonucleotides (ASOs).

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Drugs RNA Treatment Disease 105

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. Photo: Business Wire).

RNA 52

RNA DNA Engineering Virus 52

PerkinElmer

JULY 13, 2020

Imaging Modalities Help Visualize and Confirm Findings An emerging method of studying viruses is by using high-content imaging solutions to visualize the activity of small interfering RNA (siRNA), also known as short interfering RNA or “silencing” RNA.

RNA 52

RNA Virus Laboratories Science 52

NIH Director's Blog: Drug Development

SEPTEMBER 29, 2015

Each cultured 3D “organoid”—which sits comfortably in the bottom of a pea-sized well on a standard laboratory plate—comes complete with its very own neurons, support cells, blood vessels, and immune cells! The sequencing data reflect the genomic activity within the organoid following exposure to each of the 60 compounds.

RNA 52

RNA Laboratories Science Clinical Trials 52

Broad Institute

JUNE 27, 2024

CRISPRoff silences the targeted gene by adding methyl groups, chemical tags that prevent the gene from being transcribed or read into RNA and so from being expressed as protein. However, with a strong therapy design and promising laboratory results in hand, the researchers have good reason to be hopeful.

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Disease Therapies Engineering Clinical Trials 142

The Pharma Data

OCTOBER 27, 2020

. “Applying 3a’s proprietary enhanced RNA technology to PCR testing was a logical next step in our product development pipeline,” said Dr. Heinrich Jehle, managing director of 3a-Diagnostics. “We are currently developing two saliva-based tests to detect SARS-CoV-2 RNA.

RNA 52

RNA Production International Compliance 52

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

Learn how Strateos’ automated synthetic biology modules supported rapid, iterative screening of RNA sequences in modular pbuE expression system and E. Owing to their modular organization, riboswitches are ideal for engineering de novo sensing elements for use in synthetic biology. coli extract-based cell-free protein expression assays.

Engineering 52

Engineering Protein Expression Research Laboratories RNA 52

The Pharma Data

DECEMBER 17, 2020

The Early Access Program is intended to allow select customers access to the panel in their laboratories or through services to be performed in our development laboratory prior to commercial launch of this product.

Laboratories 52

Laboratories Pharmaceutical Companies Production RNA 52

Drug Target Review

FEBRUARY 5, 2024

Adult laboratory mice heal injuries with scar tissue, but spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body. It also showed that increasing and maintaining this type of signalling in laboratory mice could initiate a regenerative response instead of scarring.

Laboratories 59

Laboratories Immune Response RNA Regulations 59

Alta Sciences

MARCH 1, 2024

The new cells are then grown in high numbers in a laboratory and then are re-administered to the patient, where the genetically modified cells will attack more specific cancer cells. This technology extensively utilizes immunofluorescence and flow cytometry technology, which is a platform offered in our laboratories.

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Conversations in Drug Development Trends

AUGUST 14, 2024

Molecular Biomarkers : Encompass various molecules, such as RNA and metabolites, to reflect the physiological state of the cells and their disease pathways. FLT3 mutations seen in acute myeloid leukemia (AML) and BCR-ABL1 fusion gene seen in chronic myeloid leukemia (CML) are two examples.

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Treatment Therapies Disease Protein Expression 78

Codon

JULY 27, 2023

A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52