Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

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Broad Institute

OCTOBER 23, 2024

What is special about these synthetically designed elements is that they show remarkable specificity to the target cell type they were designed for," said Ryan Tewhey, an associate professor at The Jackson Laboratory and co-senior author of the work with Steven Reilly of Yale, and Pardis Sabeti of the Broad.

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Broad Institute

OCTOBER 16, 2024

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

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Broad Institute

FEBRUARY 24, 2025

Although this ancestral replicase appears to have been lost, key aspects of RNA-catalyzed RNA replication can be studied by proxy with the use of modern RNA enzymes (ribozymes) generated by in vitro evolution.

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RNA Molecular Biology Laboratories Engineering 52

Broad Institute

OCTOBER 17, 2024

The method, called Genotypic and Phenotypic Antibiotic Susceptibility Testing through RNA detection, or GoPhAST-R, analyzes the growth and genetic activity of the bacteria to quickly determine the pathogen’s susceptibility to various medicines.

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Broad Institute

AUGUST 19, 2024

Jude Children’s Research Hospital have discovered that oleic acid, one of the most abundant fatty acids in the body, restores a healthy balance of vaginal microbes in a laboratory model of BV. Using RNA sequencing and working with the Broad’s Metabolomics Platform and collaborators at St.

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Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

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Alta Sciences

APRIL 16, 2024

Gene therapy requires DNA and/or RNA delivery and analysis, and while most ongoing research involves therapies being delivered in vivo via adeno-associated viral (AAV) vectors, other in vivo delivery methods are on the rise. This ability to analyze variation from limited samples has made genetic diagnosis easier than ever.

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Drug Target Review

AUGUST 30, 2023

We can test their viability in the population, speeding up discovery and saving resources associated with laboratory target validation. 1 Targets were then further validated by combining testing the most promising drug candidates and knocking down specific targets using short interfering RNA (siRNA) and antisense oligonucleotides (ASOs).

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The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. Photo: Business Wire).

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PerkinElmer

JULY 13, 2020

Imaging Modalities Help Visualize and Confirm Findings An emerging method of studying viruses is by using high-content imaging solutions to visualize the activity of small interfering RNA (siRNA), also known as short interfering RNA or “silencing” RNA.

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RNA Virus Laboratories Science 52

NIH Director's Blog: Drug Development

SEPTEMBER 29, 2015

Each cultured 3D “organoid”—which sits comfortably in the bottom of a pea-sized well on a standard laboratory plate—comes complete with its very own neurons, support cells, blood vessels, and immune cells! The sequencing data reflect the genomic activity within the organoid following exposure to each of the 60 compounds.

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Drug Target Review

APRIL 9, 2024

In a previous study, we showed that these peptides decorate all cellular RNAs and thus impair the binding of RNA-binding proteins to RNA. Today, several companies have ATR inhibitors at various stages of clinical development, which to a significant extent was influenced by early works from the laboratory.

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The Pharma Data

MARCH 8, 2021

Roy Baynes, senior vice president and head of global clinical development, chief medical officer, Merck Research Laboratories. About Molnupiravir. Molnupiravir has been shown to be active in several models of SARS-CoV-2, including for prophylaxis, treatment, and prevention of transmission, as well as SARS-CoV-1 and MERS.

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The Pharma Data

OCTOBER 27, 2020

. “Applying 3a’s proprietary enhanced RNA technology to PCR testing was a logical next step in our product development pipeline,” said Dr. Heinrich Jehle, managing director of 3a-Diagnostics. “We are currently developing two saliva-based tests to detect SARS-CoV-2 RNA.

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The Pharma Data

JULY 12, 2021

The Phase 3 portion of the global MOVe-OUT trial studying molnupiravir in non-hospitalized adult patients with laboratory-confirmed COVID-19 and at least one risk factor associated with poor disease outcomes is underway. If successful, molnupiravir could help address the continued urgent need for therapeutics.”. About Molnupiravir.

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The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

Learn how Strateos’ automated synthetic biology modules supported rapid, iterative screening of RNA sequences in modular pbuE expression system and E. Owing to their modular organization, riboswitches are ideal for engineering de novo sensing elements for use in synthetic biology. coli extract-based cell-free protein expression assays.

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The Pharma Data

DECEMBER 17, 2020

The Early Access Program is intended to allow select customers access to the panel in their laboratories or through services to be performed in our development laboratory prior to commercial launch of this product.

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Conversations in Drug Development Trends

AUGUST 14, 2024

Molecular Biomarkers : Encompass various molecules, such as RNA and metabolites, to reflect the physiological state of the cells and their disease pathways. FLT3 mutations seen in acute myeloid leukemia (AML) and BCR-ABL1 fusion gene seen in chronic myeloid leukemia (CML) are two examples.

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Drug Target Review

FEBRUARY 5, 2024

Adult laboratory mice heal injuries with scar tissue, but spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body. It also showed that increasing and maintaining this type of signalling in laboratory mice could initiate a regenerative response instead of scarring.

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Alta Sciences

MARCH 1, 2024

The new cells are then grown in high numbers in a laboratory and then are re-administered to the patient, where the genetically modified cells will attack more specific cancer cells. This technology extensively utilizes immunofluorescence and flow cytometry technology, which is a platform offered in our laboratories.

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The Pharma Data

NOVEMBER 7, 2020

Flow cytometry and RNA sequencing analysis demonstrated these cells to be both cytotoxic and actively proliferating. Furthermore, RNA sequencing suggested that these cells may respond to the immune-related protein interferon, but more research is needed to confirm the significance.

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sptlabtech

JUNE 27, 2022

Farruk Kabir | NGS Lab Manager | Aperture NextGen Laboratories Aperture NextGen Laboratories is an FDA approved CLIA lab for interdisciplinary clinical testing and research. "For the last couple of years, we've been Covid testing and have been very successful with the SPT Labtech liquid handlers."

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The Pharma Data

MARCH 8, 2021

In both studies, >98% of participants who initiated treatment with Biktarvy and remained in the study achieved and maintained an undetectable viral load (HIV-1 RNA <50 copies/mL) through four years of follow-up (n=235/237 for study 1489, n=241/243 for study 1490). If appropriate, anti-hepatitis B therapy may be warranted.

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The Pharma Data

MARCH 20, 2021

Coronaviruses are RNA viruses and include common human coronaviruses, severe acute respiratory syndrome-CoV (SARS-CoV), Middle East respiratory syndrome-CoV (MERS-CoV) and SARS-CoV-2 ( 1 ). Accurate and timely laboratory diagnosis of COVID-19 is one of the most pivotal requirements for optimal disease management and contact tracing.

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The Pharma Data

SEPTEMBER 1, 2020

Point of care testing increases access to high quality diagnostics solutions for the detection of a current SARS-CoV-2 infection, regardless of laboratory testing infrastructure or patient mobility. This is highly beneficial where timely decisions are needed or laboratory testing is inaccessible.

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The Pharma Data

MAY 7, 2021

Despite PRAC’s ongoing surveillance and review, no safety signal is being found for the low platelet and clotting syndrome with either of the two authorized messenger RNA (mRNA) vaccines. Currently, EMA is evaluating “the first batch of data” for sotrovimab, including laboratory and animal studies and quality-related data, said the agency.

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Drug Target Review

SEPTEMBER 28, 2023

Researchers were able to use our synthetic RNA controls as a reference to verify and validate assays. We were able to develop these rapidly to eliminate the need to grow COVID-19 in BSL-3 labs for the purpose of making a reference sample.

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Drug Target Review

SEPTEMBER 18, 2024

At the recent ISCT 2024 – Signature Series, researchers from Charles River Laboratories presented a study 1 to predict the optimal cell culture parameters using a ML model. How is AI being integrated into current cell and gene therapy manufacturing processes to enhance operational efficiency and accelerate treatment access?

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Broad Institute

AUGUST 24, 2022

Data from standard DNA and RNA sequencing approaches were integrated with mass spectrometry-based proteomics and phosphoproteomic analyses to derive more complete molecular portraits of treatment-responsive versus treatment-resistant tumors.

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The Pharma Data

JANUARY 17, 2021

That’s not the case with RNA-targeted drugs. The Foundation also is working with contract research organizations to conduct limited preclinical studies, with Illumina and Covance for genomics data, and with Charles River Laboratories and the Korea Institute of Toxicology. “I

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The Pharma Data

NOVEMBER 4, 2020

CENTOGENE’s SARS-CoV-2 test is a molecular diagnostic test performed for the in vitro qualitative detection of RNA from the SARS-CoV-2 in oropharyngeal samples from presymptomatic patients and probands according to the recommended testing by public health authority guidelines.

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The Pharma Data

JULY 12, 2021

“Our decades-long commitment to fighting the epidemic is stronger than ever as we continue to build on our legacy of research and innovation in HIV,” said Dr. Joan Butterton, vice president, Global Clinical Development, Infectious Diseases, Merck Research Laboratories. “We If appropriate, initiation of anti-HBV therapy may be warranted.

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The Pharma Data

JANUARY 13, 2021

” The Johnson & Johnson vaccine also would be hardier than either of the already approved vaccines because it relies on DNA technology rather than messenger RNA to prompt an immune system response.

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The Pharma Data

OCTOBER 19, 2020

CTCs enable the complete picture of a cancer to be seen, as, being an intact cell, they allow DNA, RNA and protein analysis and thus provide comparable analysis to a tissue biopsy. The system is epitope independent and can capture all types of CTCs as well as CTC clusters in a viable form (alive).

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The Pharma Data

NOVEMBER 16, 2020

Moderna’s partner PPD (Nasdaq: PPD), a leading global contract research organization providing comprehensive, integrated drug development, laboratory and lifecycle management services, has also been essential to the successful execution of the COVE study. CAMBRIDGE, Mass.–(BUSINESS –(BUSINESS WIRE)–Nov.

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Codon

JULY 10, 2024

Bright light engulfs the Cultivarium laboratory in Watertown, Massachusetts. Lee showed me around the laboratories on a clear day in April. While the laboratory itself wasn’t out of the ordinary, some of its contents were. Extremophiles streaked on agar plates in the Cultivarium laboratory. Photos by the author.

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