Codon

NOVEMBER 3, 2024

Even after microbiologists discovered the bacterium that causes the illness in 1882, it wasn’t until the 1920s that researchers were able to develop a vaccine for TB. These breakthroughs have significantly curbed cases, with vaccination reducing the odds of death by 74 percent. tuberculosis , to develop the vaccine.

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KIF1A

MAY 4, 2024

Later, she developed an interest in the RNA world, specifically focusing on alternative splicing and its correlation with neuron cell properties within and across cell types. During her undergraduate studies, she worked on heart disease research in Chi Kueng Lam’s laboratory at the University of Delaware.

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The Pharma Data

MAY 7, 2021

During an early May meeting, the European Medicines Agency’s safety committee concluded two reviews of safety signals related to COVID-19 vaccines, while it continued following other vaccine-related “topics of interest.” These included reports of heart muscle inflammation after receipt of the Pfizer-BioNTech vaccine. .

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Broad Institute

JANUARY 30, 2024

He has also emerged in recent years as a skilled and relatable science communicator, renowned for his efforts at Broad and beyond during the COVID-19 pandemic to unpack the fast-moving research on the new virus in an accessible way and give practical advice about masking, vaccines, and other public health measures.

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The Pharma Data

DECEMBER 10, 2020

Unsupervised use of this technique by people without medical training can lead to transmission of pathogens, according to Paul Carlson, principal investigator in the Laboratory of Mucosal Pathogens and Cellular Immunology at FDA’s Office of Vaccines Research and Review. 1, 2019, until effective screening methods are implemented.”.

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Codon

AUGUST 27, 2024

When doctors sequenced the DNA and RNA found in Alice’s blood and synovial fluid—the liquid that surrounds and lubricates joints—they found abnormally low levels of genes encoding iron-storing proteins and high levels of epidermal growth factor receptor RNA. New Yorkers wait to receive a monkeypox vaccine.

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Codon

JULY 11, 2023

Scientists at the Institute for Protein Design have crafted proteins that self-assemble into nanomaterials or that can be used as vaccines for the flu and HIV. That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Computers are plentiful and electricity is cheap.

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The Pharma Data

JANUARY 13, 2021

13, 2021 — A single-shot COVID-19 vaccine from Johnson & Johnson has shown very strong results in early clinical trials, potentially providing a significant boost to U.S. vaccination efforts. The new vaccine remains stable for a time in the refrigerator. WEDNESDAY, Jan. 13 in the New England Journal of Medicine.

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The Pharma Data

NOVEMBER 16, 2020

The primary endpoint of the Phase 3 COVE study is based on the analysis of COVID-19 cases confirmed and adjudicated starting two weeks following the second dose of vaccine. All 11 cases occurred in the placebo group and none in the mRNA-1273 vaccinated group. The majority of adverse events were mild or moderate in severity.

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The Pharma Data

MARCH 20, 2021

As laboratories around the world tackle the challenges of screening large numbers of samples for SARS-CoV-2, the managers of these labs have turned to the use of automation to address some key concerns. As there are fewer steps carried out by hand this reduces potential exposure for laboratory staff as well. In the examples below, we.

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Codon

JULY 11, 2023

Scientists at the Institute for Protein Design have crafted proteins that self-assemble into nanomaterials or that can be used as vaccines for the flu and HIV. That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Computers are plentiful and electricity is cheap.

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RNA DNA Engineering Laboratories 52

Codon

APRIL 9, 2023

Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. npj Vaccines. Robinson A.O. Nature Biotechnology.

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Codon

APRIL 2, 2023

A giant dataset about the rat brain, and how neurons connect to each other, was collected and pooled together from 20 different research laboratories. Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). Nature Neuroscience. Andreano E.

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The Pharma Data

NOVEMBER 19, 2021

Still, PAXLOVID, which began in Pfizer’s laboratories, If approved or authorized. ” PF-07321332 is designed to block the exertion of the SARS-CoV-2-3CL protease, an enzyme that the coronavirus needs to replicate, at a stage known as proteolysis-which occurs before viral RNA replication. Food and Drug Administration (FDA).

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Broad Institute

OCTOBER 4, 2023

Today, scientists use such reactions to produce the customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and more. It is because we had the Fellowship that we could buy our very first DNA and RNA synthesizer in the lab.”

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The Pharma Data

FEBRUARY 25, 2022

“The SARS-CoV-2 vaccines target the spike protein, but this protein is under strong selection pressure and, as we have seen with Omicron, can undergo significant mutations,” said Joyce Jose, assistant professor of biochemistry and molecular biology, Penn State. ” The findings published today (Feb. Commun Biol 5, 169, 2022.

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NIH Director's Blog: Drug Development

NOVEMBER 16, 2021

That progress includes the development of life-preserving monoclonal antibody infusions and repurposing existing drugs , to which NIH’s Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV ) public-private partnership has made a major contribution. November 5, 2021. [3] Food and Drug Administration. October 14, 2021.

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PLOS: DNA Science

MARCH 30, 2023

It is also difficult to identify with standard laboratory methods,” summed up Mahmoud Ghannoum, director of the Center for Medical Mycology at University Hospitals Cleveland Medical Center. Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA).

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The Pharma Data

MARCH 22, 2022

Nirmatrelvir [PF-07321332], which originated in Pfizer laboratories, is designed to block the activity of the Mpro, an enzyme that the coronavirus needs to replicate. Nirmatrelvir is designed to inhibit viral replication at a stage known as proteolysis, which occurs before viral RNA replication.

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The Pharma Data

DECEMBER 8, 2020

Curexsys is founded by Herbert Stadler, a serial biotech entrepreneur, and Jens Gruber, a former group leader of Medical RNA Biology who is going to lead Curexsys as Chief Scientific Officer. ABOUT SARTORIUS The Sartorius Group is a leading international partner of life science research and the biopharmaceutical industry.

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Codon

MAY 15, 2023

2/ Monkey Embryos Grow to 25 Days Two Chinese groups published papers in Cell , back-to-back, that show how cultured monkey embryos can be grown in the laboratory, for up to 25 days, in 3-D gels. link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature. See the Twitter thread from Will Ratcliff.

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Codon

MAY 15, 2023

2/ Monkey Embryos Grow to 25 Days Two Chinese groups published papers in Cell , back-to-back, that show how cultured monkey embryos can be grown in the laboratory, for up to 25 days, in 3-D gels. link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature. See the Twitter thread from Will Ratcliff.

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The Pharma Data

NOVEMBER 30, 2020

(Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced that the primary efficacy analysis of the Phase 3 study of mRNA-1273 conducted on 196 cases confirms the high efficacy observed at the first interim analysis.

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The Pharma Data

JANUARY 21, 2021

In the ATLAS study, CABENUVA met the primary endpoint for noninferiority (the proportion of participants with plasma HIV-1 RNA ?50 50 copies per milliliter [c/mL] at Week 48), with a comparable number of patients receiving either CABENUVA or their daily current antiretroviral regimen (CAR) having an HIV-1 RNA level ?50

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The Pharma Data

JULY 18, 2021

Food and Drug Administration (FDA) approved VAXNEUVANCE ™ (Pneumococcal 15-valent Conjugate Vaccine) (pronounced VAKS-noo-vans) for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F and 33F in adults 18 years of age and older.

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The Pharma Data

SEPTEMBER 1, 2021

Study Now Enrolling Participants Who Live in the Same Household as Someone With Symptomatic, Laboratory-Confirmed COVID-19. The global study is enrolling individuals who are at least 18 years of age and reside in the same household as someone with laboratory-confirmed SARS-CoV-2 infection with symptoms. MOVe-AHEAD Study.

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The Pharma Data

OCTOBER 25, 2021

At 48 weeks, both trials met their primary efficacity endpoint of chance of actors with HIV-1 RNA situations ? Merck Research Laboratories. “ 50 clones/ mL, demonstrating that antiviral efficacity was similar between DOR/ ISL and ART ( ILLUMINATE SWITCH A) and between DOR/ ISL and BIC/ FTC/ TAF (ILLUMINATE SWITCH B). About Merck.

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The Pharma Data

NOVEMBER 18, 2021

As previously reported, at 48 weeks, both trials met their primary efficacy endpoint of percentage of participants with HIV-1 RNA levels ?50 All clinical studies provide important learnings to help us in the fight against HIV, and we are grateful to the patients and investigators for their contributions.”. About Merck.

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PPD

NOVEMBER 8, 2022

The approval of mRNA-based COVID-19 vaccines was a key step in reifying a mainstream future for novel therapeutic platforms, including other nucleic acid therapeutics and cell and gene therapies. Novel therapeutic platforms will drive developments in priority therapeutic areas.

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The Pharma Data

OCTOBER 27, 2021

Joan Butterton, vice chairman, global clinical development, contagious conditions, Merck Research Laboratories. The primary endpoint is the proportion of study actors with HIV-1 RNA viral cargo ? 50 c/ mL at Week 24. Lenacapavir and islatravir, alone and in combination, are investigational and not approved anywhere encyclopedically.

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Codon

AUGUST 28, 2024

A concerned employee at a laboratory supply company had called the Centers for Disease Control, or CDC, after fielding repeated calls from Harris asking when his samples of plague would arrive in the mail. She previously worked as a laboratory automation engineer and as the safety officer at the iGEM synthetic biology competition.

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The Pharma Data

JUNE 7, 2023

Rubin, senior vice president, global clinical development, Merck Research Laboratories. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines.

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Codon

NOVEMBER 1, 2024

” Nobody really knows without trying it out in the laboratory. Scientists are already building a model that can, for example, look at which RNA molecules are expressed in a cell at t=0 and predict how those molecules will change at t=1. But these models will become increasingly sophisticated over time. There are a few reasons.

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FDA Law Blog: Biosimilars

OCTOBER 24, 2024

Mutations in these genes vastly increase the risk of breast and ovarian cancer in women who carry them, and the isolation of BRCA 1/2 allowed clinical laboratories to develop tests enabling the identification of women at heightened risk. animal, viral, bacterial) DNA and RNA sequences. Supporters of AMP v.

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Codon

OCTOBER 27, 2024

The second part — focused on vaccines and medicines — will be published next Sunday, concluding Issue 04 of Asimov Press. Identifying the bacteria behind the pathogen would later set the stage for many upcoming diagnostics, treatments, and even a vaccine. Other TB tests exist, but most also rely on laboratory access.

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Codon

APRIL 16, 2023

Read The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Read [Comment] Delivering the next generation of cancer immunotherapies with RNA. Molecular Therapy.

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Promising new malaria vaccine for kids approved in Ghana. This is not the first vaccine approved to prevent malaria, but it is by far the most effective.

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