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Chemists synthesize unique anticancer molecules using novel approach

Science Daily: Pharmacology News

The chemical structures of these molecules, which consist of a dense, highly complex knot of oxidized rings and nitrogen atoms, has attracted the interest of organic chemists worldwide, who aimed to recreate these structures from scratch in the laboratory. However, despite considerable effort, it has remained an elusive task.

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New drug triggers rapid cell death in cancer models

Broad Institute

This small molecule reactivates the apoptosis cascade in tumor cells while sparing healthy cells in animal models. Previous clinical and laboratory studies on other MCL1 inhibitors have suggested that these molecules can impair heart cells, likely because of prolonged exposure to the compounds.

Drugs 133
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How to find a drug: the past, present and future of small molecule drug discovery?

DrugBaron

Despite the current hype around so called “advanced therapies”, which range from gene editing to cell therapies, and the inexorable advance of biologic therapeutics such as monoclonal antibodies, even in 2022 the majority of drugs in development and reaching patients are still small organic molecules.

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The Ultimate Guide to Effective Sample Management in the Laboratory

sptlabtech

It encompasses a range of essential tasks such as identifying, storing, handling, tracking, and retrieving individual vials within the laboratory environment. The challenge of managing samples becomes increasingly challenging as the volume of compounds handled in the laboratory grows. What are the risks of poor sample management?

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Multifaceted approach toward mapping out the anticancer properties of small molecules via in vitro evaluation on melanoma and nonmelanoma skin cancer cells, and in silico target fishing

Chemical Biology and Drug Design

To identify new lead compounds with potential anticancer properties for further optimization, in vitro assays combined with in-silico target fishing and docking have been used to identify and further map out the antiproliferative and potential mode of action of molecules from a small library of compounds previously prepared in our laboratory.

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Lilly and Kumquat Biosciences Announce Collaboration to Discover and Develop Novel Small Molecules that Stimulate Tumor-Specific Immune Responses

The Pharma Data

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

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New patent lawsuit: Galderma Laboratories, L.P. v. Dr. Reddys Laboratories, Ltd. – Drug patent: 8,206,740

Drug Patent Watch

The small molecule drug covered by this patent is ORACEA. See more details at Galderma Laboratories, L.P. Dr. Reddys… The post New patent lawsuit: Galderma Laboratories, L.P. Dr. Reddys Laboratories, Ltd. A new lawsuit citing drug patent 8,206,740 has been filed.