Conversations in Drug Development Trends

JANUARY 21, 2025

Jayaprakash Kotha, MBBS, PhD, ASCP (SH), Vice President, Bioanalytical Laboratory Satish Kumar, MBB, Head of Process Improvement Continuous Innovation is a Cornerstone of Bioanalysis Approximately 80% of drugs that begin the research process fail to reach approval. What is one contributing factor that sets the 20% that do apart from the rest?

Clinical Trials 78

Clinical Trials Laboratories Trials Drug Development 78

Broad Institute

JUNE 18, 2024

Now researchers have developed a low-cost paper strip test that could allow more patients to find out which type of flu they have and get the right treatment. Funding This work was supported by the Defense Advanced Research Projects Agency, the Centers for Disease Control and Prevention, the Flu Laboratory, and the TED Audacious Project.

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Virus RNA Laboratories Medical Schools 144

Precision for Medicine

DECEMBER 1, 2023

December 1, 2023 — Precision for Medicine, the first global biomarker-driven clinical research organization, is the recipient of a new accreditation from The College of American Pathologists (CAP) for its tissue and histopathology laboratory in Winston-Salem, North Carolina. Winston-Salem, Nc.,

Laboratories 45

Laboratories Clinical Trials Clinical Research Compliance 45

Broad Institute

OCTOBER 21, 2024

By Leah Eisenstadt October 21, 2024 Credit: Kevin Middleton, Broad Communications In the Bhattacharyya lab, researchers develop methods to quickly identify the most appropriate treatments for bacterial infections. The findings appear in the Journal of Clinical Microbiology.

RNA 115

RNA Hospitals Laboratories Medical Schools 115

KIF1A

MARCH 2, 2024

Read the Article Rare Roundup The Jackson Laboratory offers “Exploring Rare Disease Through Translational Research” MiniCourse Human health is incredibly complex; developing safe, effective treatments requires knowledge of molecular mechanisms, cell biology, and drug administration.

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Laboratories Cell Biology Disease Research 119

Conversations in Drug Development Trends

NOVEMBER 27, 2023

Casgevy, the commercial product formerly known as exa-cel, is administered by taking stem cells out of a patient’s bone marrow and editing a gene in the cells in a laboratory, with the modified cells then infused back into the patient after conditioning treatment to prepare the bone marrow.

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Treatment FDA Clinical Trials Therapies 75

SCIENMAG: Medicine & Health

AUGUST 14, 2023

After a highly lauded research campaign that successfully redesigned a hepatitis C drug into one of the leading drug treatments for COVID-19, scientists at the Department of Energy’s Oak Ridge National Laboratory are now turning their drug design approach toward cancer. Credit: Credit: Jill Hemman/ORNL, U.S.

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Laboratories Treatment Research Drugs 89

Conversations in Drug Development Trends

NOVEMBER 12, 2024

Modifying and expanding the cells in a GMP laboratory. Cell therapy can be effective, but clinically testing the treatment presents several logistical challenges that require early planning and rigorous management by specialized and experienced teams throughout the clinical trial timeline.

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Therapies Clinical Supply Clinical Trials Trials 72

ASPET

JANUARY 31, 2024

Recently, our laboratory reported that lucanthone slows GBM by inhibiting autophagic flux through lysosome targeting and decreases the number of Olig2+ glioma stem-like cells (GSC) in vitro and in vivo. Our results suggest that lucanthone may function as a potential treatment option for GBM tumors that are not amenable to TMZ treatment.

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Therapies FDA Approval Laboratories Treatment 100

Drug Target Review

APRIL 17, 2024

What are the potential implications of the research findings for cancer risk assessment, prevention strategies, and treatment approaches? Dr Chowell spent a year as a visiting graduate student at the Moe Win Laboratory for Information and Decision Systems at MIT.

Immune Response 105

Immune Response Laboratories DNA Virus 105

Broad Institute

AUGUST 19, 2024

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections.

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Hospitals Treatment Medical Schools Science 121

SCIENMAG: Medicine & Health

AUGUST 18, 2023

FINDINGS Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have identified how low levels of the TET2 gene fuel the rapid growth of acute myeloid leukemia in animal models. Credit: Jianjun Chen Laboratory/City of Hope FINDINGS Scientists at […]

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Research Laboratories Treatment 84

ASPET

SEPTEMBER 12, 2023

Opioid self-administration behavior in laboratory subjects can be reinstated by priming with MOR agonists or agonist-related stimuli, providing a procedure comparable to relapse. However, chronic naltrexone treatment has not been extensively investigated in nonhuman subjects and aspects of its pharmacology remain uncertain.

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Laboratories Treatment Drugs 100

NIH Director's Blog: Drug Discovery

NOVEMBER 5, 2020

In work published in the journal ACS Nano , a team that included Kirill Gorshkov, NIH’s National Center for Advancing Translational Sciences (NCATS), Rockville, MD, along with Eunkeu Oh and Mason Wolak, Naval Research Laboratory, Washington, D.C., Naval Research Laboratory (Washington, D.C.) That’s not science fiction. That’s now.

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Research Laboratories Laboratories Science Drugs 85

The Pharma Data

AUGUST 31, 2021

In addition, as part of the label update, this indication has been revised to be for the treatment of patients with locally advanced or metastatic urothelial carcinoma (mUC) who are not eligible for any platinum-containing chemotherapy.

FDA Approval 52

FDA Approval Treatment FDA Research Laboratories 52

The Pharma Data

OCTOBER 22, 2020

FDA Approves Veklury (remdesivir) for the Treatment of COVID-19. Food and Drug Administration (FDA) has approved the antiviral drug Veklury (remdesivir) for the treatment of patients with COVID-19 requiring hospitalization. FOSTER CITY, Calif.–(BUSINESS –(BUSINESS WIRE)–Oct. 22, 2020– Gilead Sciences, Inc.

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FDA Approval Treatment FDA Hospitals 52

The Pharma Data

APRIL 15, 2022

Designed computationally and refined in the laboratory, the new protein therapies thwarted infection by interfering with the virus’ ability to enter cells. The top protein neutralized the virus with similar or greater potency than antibody treatments with Emergency Use Authorization status from the U.S. 2 omicron subvariant.

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Treatment Virus Laboratories Engineering 52

Drug Target Review

MARCH 19, 2024

Our polygenic score will enable the application of these treatments to people that specifically need it through precision medicine by identifying the individual at high genetic risk of low circulating levels of the vitamin. The answer is no because there are both genetic and dietary (environmental) causes for low vitamin A.

Laboratories 105

Laboratories Bioinformatics International Research Laboratories 105

ASPET

JULY 20, 2023

Nitrogen mustard (NM), a bifunctional alkylating agent and potent analog of SM, is used in laboratories to study mustard vesicant-induced ocular toxicity. Previously, we showed that SM-/NM-induced injuries ( in vivo and ex vivo rabbit corneas) are reversed upon dexamethasone (DEX) treatment, an FDA approved, steroidal anti-inflammatory drug.

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FDA Approval Laboratories Treatment FDA 100

Drug Target Review

DECEMBER 11, 2024

Our approach, grounded in Good Laboratory Practice (GLP) and honed through thousands of studies, ensures that even the most subtle toxicological indicators are reliably detected. Sompura, Method Development Team Lead at Sannova Analytical, brings over 18 years of experience in the Bioanalytical Laboratory Department.

International 52

International Laboratories Drugs Pharmacokinetics 52

The Pharma Data

AUGUST 22, 2021

The findings, published online in The American Journal of Geriatric Psychiatry , evaluated the long-term use of AUSTEDO with the total motor Abnormal Involuntary Movements Scale (AIMS) score, and measures of treatment success and quality of life. About AUSTEDO (deutetrabenazine) Tablets. Indications and Usage. IMPORTANT SAFETY INFORMATION.

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Treatment Disease Therapies Pharmaceuticals 52

SCIENMAG: Medicine & Health

JUNE 26, 2023

Copenhagen, Denmark: Women are just as likely to give birth to live babies after fertility treatment if embryos are transferred to their wombs three days after fertilisation in the laboratory rather than five.

Clinical Trials 69

Clinical Trials Laboratories Trials Treatment 69

DrugBank

MARCH 28, 2024

The harsh conditions of space act as a natural laboratory, speeding up the progression of diseases and aging, offering unique insights that can be leveraged for medical advancements on Earth.

DNA 144

DNA Laboratories Disease Engineering 144

The Pharma Data

OCTOBER 29, 2021

Novartis blazoned moment that the US Food and Drug Administration (FDA) approved Scemblix ® (asciminib) for the treatment of habitual myeloid leukemia (CML) in two distinct suggestions. The blessing of Scemblix may offer stopgap to cases by addressing gaps in CML care.” Bosulif ® (bosutinib) * at 24 weeks (25vs. sites/www.novartis.us/files/scemblix.pdf.

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FDA Approval Treatment FDA Trials 52

Labcorp Drug Development

APRIL 24, 2023

Every clinical trial relies on data from its study participants to inform decisions regarding the safety and efficacy of a potential new treatment. Clinical trial sponsors rely on the data from laboratory tests to bring clear insights that advance studies. 4 core services to know appeared first on Insights From Our Labs to Yours.

Clinical Trials 52

Clinical Trials Laboratories Trials Treatment 52

The Pharma Data

MARCH 8, 2021

In both studies, >98% of participants who initiated treatment with Biktarvy and remained in the study achieved and maintained an undetectable viral load (HIV-1 RNA <50 copies/mL) through four years of follow-up (n=235/237 for study 1489, n=241/243 for study 1490). BOXED WARNING: POST TREATMENT ACUTE EXACERBATION OF HEPATITIS B.

Treatment 52

Treatment Therapies RNA Laboratories 52

Drug Target Review

NOVEMBER 6, 2023

Advances in research and development and the utilisation of combination treatment strategies are revolutionising the haematology care landscape, but more must be done to address patients’ individual needs. Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium. Falzone L, Salomone S, Libra M.

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Small Molecule Therapies Treatment Disease 111

PPD

OCTOBER 31, 2024

Patient recruitment and clinical laboratory and diagnostic services are the top drug development activities likely to be outsourced, similar to previous reports. This aims to ensure that treatments are effective across varied demographics and to address historical gaps in clinical research.

Drug Development 52

Drug Development Clinical Trials Trials Drugs 52

Drug Target Review

JANUARY 2, 2024

This proved that patient treatment population and customised isolation of the stem cells’ identities and their bioenergetic organelle function should be considered when selecting the tissue source. The experiment comprised two components: computational methodology development and laboratory experiments.

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RNA Immune Response Therapies Disease 128

The Pharma Data

JANUARY 13, 2021

Food and Drug Administration (FDA) has designated as a Fast Track development program the investigation of Brilacidin as a potential treatment for COVID-19. Laboratory testing at independent laboratories supports Brilacidin’s antiviral ability to safely and potently inhibit SARS-CoV-2, and multiple strains of human coronaviruses (H-CoVs).

Clinical Trials 52

Clinical Trials Trials Treatment Pharmaceuticals 52

Elrig

MARCH 25, 2025

In 2016, he was appointed Junior Group Leader with the Swiss National Centre for Competence in Research (NCCR) in RNA & Disease, where he established the laboratory for Genomics Of LncRNAs in Disease (GOLD Lab).

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Alta Sciences

NOVEMBER 4, 2024

With airlocks around the manufacturing and laboratory areas, staff could safely gown and de-gown. Product Disposal: We disposed of all waste and material generated from the manufacturing loteprednol etabonate at regulated chemical treatment facilities.

Engineering 52

Engineering Production Compliance Laboratories 52

The Pharma Data

AUGUST 19, 2021

The Janssen Pharmaceutical Companies of Johnson & Johnson today announced preliminary data from the Phase 1 CHRYSALIS study evaluating RYBREVANT TM (amivantamab-vmjw) for the treatment of patients with non-small cell lung cancer (NSCLC) with mesenchymal-epithelial transition (MET) exon 14 skipping (METex14) mutations. 4] , [5] , [6].

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Treatment FDA Approval Pharmacokinetics FDA 52

The Pharma Data

MARCH 13, 2021

“Lanadelumab is a fully human monoclonal antibody that specifically binds and decreases plasma kallikrein activity, with a proven efficacy and safety profile as a preventive treatment for HAE attacks. Subject to approval, we are looking forward to providing lanadelumab as a new treatment option for patients in Japan living with HAE.”.

Treatment 52

Treatment Pharmacokinetics Drugs Production 52

PPD

JUNE 24, 2024

Big data: The role of big data and real-world data (RWD) will continue to expand, providing deeper insights into patient behaviors, disease patterns and treatment effectiveness in real-world settings.

Vaccine 97

Vaccine Trials Clinical Trials Laboratories 97

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. The editing molecules are also smaller, potentially making it easier to deliver them into cells in key parts of the body as new disease treatments.

DNA 145

DNA RNA Engineering Laboratories 145

Broad Institute

OCTOBER 17, 2024

By Leah Eisenstadt October 17, 2024 Credit: Kevin Middleton, Broad Communications In the Bhattacharyya lab, researchers develop methods to quickly identify the most appropriate treatments for bacterial infections. The findings appear in the Journal of Clinical Microbiology (link).

RNA 69

RNA Hospitals Laboratories Medical Schools 69