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This edition includes Maze’s glycogen synthase 1 (GYS1) inhibitors that were recently licensed to Sanofi, allosteric androgen receptor (AR) modulators that may be of interest to targetedproteindegradation researchers, and brain-penetrant HER2 and ROCK2 inhibitors.
This collaboration has the potential to be transformational, as it combines our leadership in targetedproteindegradation with Pfizer’s global capabilities and deep expertise in breast cancer. Arvinas and Pfizer are seeking to develop ARV-471 as the potential endocrine therapy of choice for patients and their physicians.
In-licensing molecules from other players, due to a partner’s strategic shifts, budget challenges, or geographic access, can be a great way to jumpstart early stage companies around more advanced assets. That deal catalyzed it’s next financing and IPO… but the asset eventually failed. Intellia, Kymera , Dyne, Replimune, etc).
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