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Tech Focus: How is HTS accelerating early-stage drug discovery?

Drug Discovery World

For example, multiple RNA helicases are being targeted for cancer and viral infections before their catalytic properties are well understood. She brings 18 years’ experience in both print and digital editorial roles for B2B publications dedicated to the life sciences sector, including medical and pharmaceutical industry journals/magazines.

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Codon Digest: Discovering Antibiotics with Deep Learning

Codon

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Read more in Nature Methods.

DNA 52
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Codon Digest: Discovering Antibiotics with Deep Learning

Codon

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Read more in Nature Methods.

DNA 52
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Codon Digest: Moore's Law

Codon

Link Experimental Tests of the Virtual Circular Genome Model for Nonenzymatic RNA Replication. Link Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase. Link U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes. Link Probing metabolism in an E.

DNA 52
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Codon Digest: GPT-4 Controls a Robot

Codon

Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Read [Comment] Delivering the next generation of cancer immunotherapies with RNA. Comparison of transformations for single-cell RNA-seq data. Read Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape.