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Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. ” Quanta Magazine. If you want to edit a gene inside of a neuron, what do you do? These fat bubbles are injected straight through the skull.
Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. ” Quanta Magazine. If you want to edit a gene inside of a neuron, what do you do? These fat bubbles are injected straight through the skull.
A phage is a virus that infects bacteria. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. ” Bacteriophages infect a bacterium. They’re incredibly versatile. in Nature.
A phage is a virus that infects bacteria. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. ” Bacteriophages infect a bacterium. They’re incredibly versatile. in Nature.
The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Base editor proteins were delivered into the mice using a virus, called AAV9. coli genes into a piece of simian virus DNA. Asterisk Magazine 13 of 31. Biology is a Burrito.
Some scientists even think it had a virus defense system; “researchers say LUCA likely housed 19 CRISPR genes, which bacteria use to slice up viral threats,” reports Quanta Magazine. DNA and RNA molecules are also built from exclusively right-handed nucleic acids.
The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Read more in Nature Methods.
The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Read more in Nature Methods.
Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Comparison of transformations for single-cell RNA-seq data.
Influenza incidence and severity are increasing , against a backdrop of novel drifts (small genetic changes) and shifts (larger changes) to the virus, all against a backdrop of novel infection pathways, such as birds to cows to people. The mRNA in COVID vaccines tells cells to produce the virus’s spike protein.
Link Experimental Tests of the Virtual Circular Genome Model for Nonenzymatic RNA Replication. Link U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes. Link A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth. Link Probing metabolism in an E. Mimoso C.A.
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