KIF1A
JUNE 30, 2023
With these models established, we are preparing to test our first batch of small molecules drugs later this year! Dr. Kaur now oversees 5 KAND research projects that utilize our patient-derived cell lines to screen for small molecule therapeutics and test potential gene therapies.
New Drug Approvals
SEPTEMBER 13, 2024
“LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders” Neuropharmacology. PMID 34826432. Rorick-Kehn LM, Witkin JM, Statnick MA, Eberle EL, McKinzie JH, Kahl SD, et al. February 2014). 77 : 131–144.
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PLOS: DNA Science
JUNE 22, 2023
The candidate drug, vorasidenib, is a small molecule that inhibits survivin. Gleevec came from a massive effort throughout the 1980s to screen more than 400 small molecules for one that would block the activity of the errant tyrosine kinase, without derailing other important enzymes. It is a cyclin-dependent kinase.
Codon
APRIL 16, 2023
” Joshua Sokol for Quanta Magazine. Read Aer Therapeutics, a University of California, San Francisco lab spinout developing an inhaled small molecule drug for chronic obstructive pulmonary disease, raised $36 million in a Series A. Read Postdocs who work in an HHMI laboratory now get a minimum salary of $70,000.
Codon
MAY 30, 2023
Read Programming inactive RNA-binding small molecules into bioactive degraders. My essay for Works in Progress magazine. Molecular Therapy. Read Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies. Nature Communications. ACS Synthetic Biology. eClinicalMedicine. .
Codon
MAY 30, 2023
Read Programming inactive RNA-binding small molecules into bioactive degraders. My essay for Works in Progress magazine. Molecular Therapy. Read Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies. Nature Communications. ACS Synthetic Biology. eClinicalMedicine. .
Codon
DECEMBER 12, 2024
Some scientists even think it had a virus defense system; “researchers say LUCA likely housed 19 CRISPR genes, which bacteria use to slice up viral threats,” reports Quanta Magazine. The most obvious defense would not be vaccines, but rather antibiotics; small molecules that treat or prevent bacterial infections.
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