Marketing and Screening Hits - Drug Discovery Digest

Advancements in hit identification for membrane protein drug discovery

Drug Target Review

APRIL 7, 2025

Advancements in screening technologies for small-molecule drug discovery including cellular assays, computational screening, and biophysics-based methods enhanced by structural biology breakthroughs have improved screening hit rates and facilitated the identification of drug candidates for previously undruggable targets.

Fragment Screening

Fragment Screening Drugs Small Molecule Biophysical Assays

How to Get Drugs Into the Brain

Drug Hunter

AUGUST 21, 2023

A) Progression of a Novartis HAT program from a screening hit to brain-penetrant leads. This program started from an HTS screen of 3M compounds, resulting in a singleton hit (Figure 17). Figure 18. B) Results from a computational model of brain-penetration correlated well with actual K p ’s across the series.

Drugs

Drugs Disease Targeted Protein Degradation Screening Hits

Drug Discovery Digest

Advancements in hit identification for membrane protein drug discovery

How to Get Drugs Into the Brain

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