Marketing, Screening Hits and Trials

Advancements in hit identification for membrane protein drug discovery

Drug Target Review

APRIL 7, 2025

Advancements in screening technologies for small-molecule drug discovery including cellular assays, computational screening, and biophysics-based methods enhanced by structural biology breakthroughs have improved screening hit rates and facilitated the identification of drug candidates for previously undruggable targets.

Fragment Screening

Fragment Screening Drugs Small Molecule Biophysical Assays

How to Get Drugs Into the Brain

Drug Hunter

AUGUST 21, 2023

Overall, only a few prodrugs for CNS disorders have even reached clinical trials , so for the most part traditional property-based drug design remains the best bet for the vast majority of programs. A) Progression of a Novartis HAT program from a screening hit to brain-penetrant leads. What is K p,uu ? Figure 18.

Drugs

Drugs Disease Targeted Protein Degradation Screening Hits

Drug Discovery Digest

Advancements in hit identification for membrane protein drug discovery

How to Get Drugs Into the Brain

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