Drug Target Review

APRIL 7, 2025

Advancements in screening technologies for small-molecule drug discovery including cellular assays, computational screening, and biophysics-based methods enhanced by structural biology breakthroughs have improved screening hit rates and facilitated the identification of drug candidates for previously undruggable targets.

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The Pharma Data

NOVEMBER 19, 2020

The Company is also aiming to leverage the highly conserved structure of the SARS-CoV-2 M pro protease as a basis for the design of novel oral small molecules against predicted future variants of SARS-CoV-2 and other related human viruses.

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Small Molecule Structure Based Drug Design (SBDD) Molecular Biology International 40

The Pharma Data

NOVEMBER 30, 2020

Biohaven acquires exclusive global rights to a portfolio of novel, small-molecule CGRP antagonists. The lead candidate, HTL0022562, has advanced through preclinical development demonstrating promising and differentiated properties for further investigation in human trials. Vlad Coric , M.D.,

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The Pharma Data

SEPTEMBER 10, 2021

This is the first marketing authorization globally for abrocitinib-. This is the first marketing authorization globally for abrocitinib-. This is the first marketing authorization worldwide for this treatment. “We CIBINQO (abrocitinib) is an oral small molecule that selectively inhibits Janus kinase (JAK) 1.

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The Premier Consulting Blog

NOVEMBER 20, 2024

In the case of urgent or immediate public interest, process validation may be conducted concurrently with manufacturing the commercial small molecule or biologic product to expedite product availability for patients.

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DrugBank

OCTOBER 17, 2024

By utilizing high-resolution protein structures obtained through X-ray crystallography, researchers could design small molecules that potently inhibit the SARS-CoV-2 main protease, a key enzyme essential for viral replication.

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Drug Target Review

APRIL 7, 2025

Novel mechanisms of action associated with CGTs naturally create dosing effects that apply in very different ways than with traditional small molecule pharmacotherapies.

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The Pharma Data

JUNE 22, 2023

Kite Announces Completion of Marketing Authorization Transfer for Yescarta® CAR T-cell Therapy in Japan SANTA MONICA, Calif.–(BUSINESS in December 2022 about changes to their initial 2017 partnership whereby Daiichi Sankyo obtained the Marketing Authorization for Yescarta ®. –(BUSINESS WIRE)– Kite Pharma, Inc.,

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Conversations in Drug Development Trends

APRIL 4, 2024

Stability Tests: For small molecule, only -20°C stability testing is required, while large molecule need both -20°C and -70°C tests if samples are intended for storage at these temperatures. Select the right partner with experience meeting regulatory standards for all target markets.

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Alta Sciences

FEBRUARY 10, 2025

As a leading CRO, we provide a suite of unparalleled services designed to streamline your path to market. Contact us to get started!

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The Pharma Data

NOVEMBER 22, 2020

SAN DIEGO–( BUSINESS WIRE )– Vividion Therapeutics , a biotechnology company discovering and developing selective small molecule medicines that drug traditionally inaccessible targets, today announced that Jeffrey Hatfield has been appointed as the company’s chief executive officer. market access. 23, 2020 13:30 UTC.

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Nvidia Developer: Drug Discovery

MARCH 21, 2023

Creating new drug candidates is a heroic endeavor, often taking over 10 years to bring a drug to market. Creating new drug candidates is a heroic endeavor, often taking over 10 years to bring a drug to market. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

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Drug Target Review

JUNE 19, 2024

Transplanting cells could prove to be more beneficial than treating a particular condition with a small molecule or an antibody, and that really speaks to the power of cell therapy. Just like small molecules and antibodies, cell therapies are changing how we treat patients.

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Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

The Pharma Data

JANUARY 25, 2021

–( BUSINESS WIRE )– Veralox Therapeutics, a biotechnology company developing first-in-class small molecule therapeutics that treat the underlying pathologies of diseases with significant unmet medical needs, today announced that the U.S. 26, 2021 13:00 UTC. FREDERICK, Md.–( About VLX-1005.

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The Pharma Data

AUGUST 7, 2021

Vividion’s platform is able to produce a variety of small molecule therapies across indications, with initial focus on targets relevant to oncology and immunology. The acquisition of Vividion strengthens Bayer’s small molecule capabilities and expands Bayer’s reach into new modalities.

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LifeSciVC

APRIL 24, 2024

and whether a molecule’s pharmacology can help to mitigate safety risk. Especially for oligo or small molecule discovery and development, it’s important to understand whether there are highly homologous sequences or proteins that may be impacted by a given therapeutic approach. in liver, in CNS)? Consider Fig.

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The Pharma Data

NOVEMBER 29, 2020

(Headquarters: Cambridge, UK, “Wren”) today announced that the companies have entered into an exclusive research collaboration agreement aiming to advance the discovery of novel small molecules that target ?-synuclein synuclein for the potential treatment of synucleinopathies including Parkinson’s disease and dementia with Lewy bodies.

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PerkinElmer

SEPTEMBER 8, 2019

Over the last 20 years, Cisbio has become a leading Life Sciences company which develops, manufactures, and markets high quality kits and reagents for the drug discovery and life science markets used by pharmaceutical, biotechnology, academia and contract research organizations across the globe. Learn more about Cisbio here.

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Cell Based Assays Small Molecule Science Pharmaceuticals 52

The Pharma Data

OCTOBER 4, 2021

The GSK structures were collected at different stages of the pharmaceutical pipeline and are not limited to marketed products. The authors at GSK and CCDC completed a robust analysis of the small molecule crystal structures containing X-ray diffraction results from GSK and its heritage companies for the past 40 years.

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The Pharma Data

NOVEMBER 26, 2020

This novel nanoparticle formation technology provides hope for improving the possibilities and probabilities of developing better medicines for patients and it expands Nanoform’s reach into the growing biological market. Edward Hæggström, Nanoform CEO: “Small is powerful, also in Bio! ” Prof. Finnish time.

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Molecular Design

DECEMBER 31, 2024

My pulse will be quickenin' With each drop of strychnine We feed to a pigeon It just takes a smidgin To poison a pigeon in the park Tom Lehrer, Poisoning Pigeons in the Park | video ** Ill be reviewing the H2024 study (Occurrence of Natural Selection in Successful Small Molecule Drug Discovery) in this post.

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The Pharma Data

JUNE 28, 2021

Broadens company’s oncology platform of Targeted Alpha Therapies / Acquisition includes actinium-225 labeled differentiated PSMA small molecule for the treatment of prostate cancer. Bayer today announced that it has entered into an agreement to acquire Noria Therapeutics Inc. Noria) and PSMA Therapeutics Inc.

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The Pharma Data

JANUARY 13, 2021

Knopp’s clinical-stage oral small molecule, dexpramipexole, is in Phase 2 clinical trials in moderate-to-severe eosinophilic asthma. Knopp’s preclinical Kv7 platform is directed to small-molecule treatments for developmental and epileptic encephalopathies, other epilepsies, neuropathic pain, and tinnitus.

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Drug Target Review

JANUARY 4, 2024

This is in part due to a complex manufacturing process, which is harder to control than those used for other modalities (such as small molecules and monoclonal antibodies). By this point, we have undertaken a thorough analysis of what the market will look like at the anticipated product launch, including potential reimbursement models.

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New Drug Approvals

OCTOBER 12, 2024

After tramiprosate failed in Phase 3, its maker, NeuroChem, marketed it as a nutritional supplement. A more recent study found that homotaurine activates GABA receptors, and suggests an alternative mechanism of action for ALZ-801 ( Meera et al., 2016 ; Abushakra et al., 2016 ; Abushakra et al.,

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The Pharma Data

NOVEMBER 11, 2020

As an orally bioavailable small molecule with broad antiviral activity, SLV213 could be a valuable treatment to meet today’s urgent need to fight COVID-19 as well other life-threatening infectious diseases, such as Chagas disease, Ebola virus disease, and Nipah virus infection.”. About SLV213.

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LifeSciVC

AUGUST 5, 2024

The Nimbus experience to date is that this merger of scientific disciplines shows less benefit in speed and much clearer benefit in a wider range of tractable drug discovery targets and enhancement in the quality of small molecule clinical candidates developed. a company with the strongest pipeline in the entire industry.”

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The Pharma Data

DECEMBER 15, 2020

So far, Enveda has validated three candidates, which target the liver fibrosis, inflammation and neurodegenerative markets. Its platform applies cutting-edge advancements in knowledge graphs, metabolomics, and machine learning to discover the next generation of small molecule therapeutics.

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The Pharma Data

NOVEMBER 15, 2020

Urovant’s lead drug candidate, vibegron, is an oral, once-daily small molecule beta-3 agonist being evaluated for the treatment of OAB, abdominal pain associated with irritable bowel syndrome (IBS) in men with OAB, and for men suffering from OAB with benign prostatic hyperplasia (BPH).

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PPD

OCTOBER 18, 2023

As exponential growth and global expansion continue in both the biotech and pharmaceutical industries, it is critical for drug development companies to partner with good manufacturing practices (GMP) / chemistry manufacturing and controls (CMC) contract labs to conduct analyses of a range of small molecules and biologics and drive therapies forward (..)

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The Pharma Data

APRIL 6, 2021

The product is approved in several markets around the world, including the U.S., Approximately 2-3% of all non-small cell lung cancers (NSCLC) have an in-frame insertion within exon 20 of the EGFR, which has been linked to resistance of approved EGFR tyrosine kinase inhibitors, posing a very high unmet medical need for these patients.

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Practical Cheminformatics

JANUARY 8, 2024

The authors provided examples where GPT-4 could provide a SMILES string, IUPAC name, or descriptive text for a marketed drug. pBRICS: A Novel Fragmentation Method for Explainable PropertyPredictionof Drug-Like Small Molecules [link] Perspective: I can’t say I saw a lot of progress in explainable AI for molecules this year.

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Alta Sciences

AUGUST 29, 2024

The global market for CNS therapeutics is a multi-billion-dollar industry, and is projected to grow from $102.4 Large molecules are less able to penetrate the blood/brain barrier to deliver therapeutic results and thus most CNS-active drugs are small molecules.” --The Altascientist, Issue 33, pg.

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The Pharma Data

OCTOBER 27, 2020

Attention: Equity Capital Markets, 55 East 52nd Street, 35th Floor, New York, NY 10055, or by telephone at (888) 474-0200, or by email at ecm.prospectus@evercore.com. Adagrasib is an investigational small molecule and selective KRAS G12C inhibitor in clinical development as a monotherapy and in combinations.

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The Pharma Data

DECEMBER 21, 2020

Program focused on identifying small molecules that target a GPCR for degradation as potential therapeutic agents for gastrointestinal disorders. The principle of TPD is to use small molecules to commit the target protein into the E3 ligase-mediated degradation pathway thereby eliminating or reducing its activity.

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Targeted Protein Degradation Small Molecule Structure Based Drug Design (SBDD) Drugs 40

Drug Target Review

JULY 31, 2023

If you are collaborating with all of these different people, if you’re providing the small molecule tools for lots of different projects, how can I evaluate you as an independent scientist?” When I started in academics 16 years ago, I heard the question, “how can I evaluate your work if you are not the last author?

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The Pharma Data

OCTOBER 6, 2021

The European Commission (EC) will review the CHMP recommendation and is expected to make a final decision on a variation to the Conditional Marketing Authorization in the near future. years of age and older. If the EC grants the variation regarding a booster dose, the decision will be immediately applicable to all 27 EU member states.

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