Broad Institute

AUGUST 7, 2023

A surprising new role for a major immune regulator By Tom Ulrich August 7, 2023 Breadcrumb Home A surprising new role for a major immune regulator By Anne Trafton, MIT News August 7, 2023 Credit: RCSB Protein Data Bank A model of the human STING protein. Paper Cited Liu B, Carlson R, et al. Human STING is a proton channel.

Regulations 91

Regulations Clinical Trials Engineering DNA 91

Drug Target Review

FEBRUARY 26, 2024

Our data demonstrate that the CoREST complex is a critical mediator of the distinct melanoma phenotypes, working through the regulation of both the phenotype-defining genes MITF and AXL as well as the master regulators of epithelial-to-mesenchymal transitions (EMT) and phenotype switching in melanoma and other cancers, SNAIL/SLUG/ZEB1/ZEB2.

Therapies 59

Therapies Molecular Biology Regulations Medical Schools 59

Drug Target Review

JULY 1, 2024

SRP-001 targets the central nervous system (CNS) by producing N-arachidonoylaminophenol (AM404) in the midbrain’s periaqueductal grey (PAG) region, crucial for pain sensation and regulation. He and his team have completed Phase I clinical trials, paving the way for Phase II RCTs in acute and neuropathic pain.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Broad Institute

NOVEMBER 20, 2024

Scientists find a region of the mouse gut tightly regulated by the immune system By Allessandra DiCorato November 20, 2024 Breadcrumb Home Scientists find a region of the mouse gut tightly regulated by the immune system A spatial map of gene expression across the intestine reveals the organ’s remarkable adaptability.

Regulations 84

Regulations Immune Response Molecular Biology Disease 84

Codon

JUNE 26, 2023

Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. … There was a time when the film was being shown in biology courses from middle school to graduate courses in genetics and biochemistry and even in post graduate education lectures to physicians.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. … There was a time when the film was being shown in biology courses from middle school to graduate courses in genetics and biochemistry and even in post graduate education lectures to physicians.

DNA 52

DNA Therapies Engineering Clinical Trials 52