Drug Target Review

JUNE 6, 2023

This suppressive mechanism involves a negative regulator – a protein called IL-18BP or IL-18 binding protein, that works as a “decoy receptor” by binding to IL-18 and preventing it from binding to its functional receptor. Clinical development of IL-18 therapies has been curtailed, however, by the protein’s lack of efficacy.

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Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

Drug Target Review

FEBRUARY 26, 2024

Our data demonstrate that the CoREST complex is a critical mediator of the distinct melanoma phenotypes, working through the regulation of both the phenotype-defining genes MITF and AXL as well as the master regulators of epithelial-to-mesenchymal transitions (EMT) and phenotype switching in melanoma and other cancers, SNAIL/SLUG/ZEB1/ZEB2.

Therapies 59

Therapies Molecular Biology Regulations Medical Schools 59

Broad Institute

AUGUST 2, 2023

Known to be a regulator of metabolism, we have found that in addition it has profound behavioral effects in animals and humans, even evident in population-level economic behavior. Daniel Hochbaum Daniel Hochbaum Daniel Hochbaum, Harvard Medical School Daniel Hochbaum, Ph.D. T3 is the active form of thyroid hormone.

Medical Schools 52

Medical Schools Disease Science International 52

The Pharma Data

DECEMBER 3, 2020

The phosphorylation of proteins has a major role in regulating protein function inside cells—these processes are typically highly controlled in normal, healthy cells. They were able to prove that the lack of the mps-2 gene resulted in decreased MPS-2 protein, which is an actively regulated process.

Disease 52

Disease Research Virus Hospitals 52

Drug Target Review

JULY 1, 2024

SRP-001 targets the central nervous system (CNS) by producing N-arachidonoylaminophenol (AM404) in the midbrain’s periaqueductal grey (PAG) region, crucial for pain sensation and regulation. He was bestowed the 2024 NIH HEAL Director’s Trailblazer Award for this work.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

NIH Director's Blog: Drug Development

APRIL 2, 2020

The protein is known to play a prominent role in the body’s complex system of regulating blood pressure. The ACE2 protein resides on the surface of cells in many parts of the human body, including the heart and lungs. These ACE inhibitors lower blood pressure by causing blood vessels to relax. The team, led by Scott D.

Drug Development 52

Drug Development Drugs Science Medical Schools 52

The Pharma Data

MAY 17, 2021

Two papers in JAMA Internal Medicine highlighted separate, but important issues concerning the US Food and Drug Administration’s authority to modify package inserts and the effect of a recently shuttered agency initiative. In a Viewpoint, Bishal Gyawali, MD, PhD, and colleagues at the Program on Regulation, Therapeutics and Law (PORTAL) research (..)

Research 52

Research FDA Approval Drugs FDA 52

Broad Institute

JUNE 21, 2023

LipocyteProfiler swaps concanavalin A, the dye that stains the ER, with BODIPY, which stains lipid droplets: fat-storing organelles that regulate lipids within every type of cell and which are particularly common in adipocytes (fat cells).

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

The Pharma Data

MARCH 13, 2021

Zucker professor of Psychiatry and Human Behavior, Department of Neurology, Warren Alpert Medical School of Brown University. “The donanemab results are a significant and encouraging milestone for people impacted by Alzheimer’s disease and we are eager to continue on in this fight.”

Disease 40

Disease Trials Treatment Medical Schools 40

Agency IQ

JUNE 7, 2024

BY CHELSEY MCINTYRE, PHARMD | JUN 3, 2024 8:43 PM CDT Regulatory background: DSHEA and dietary supplements The Dietary Supplement Health and Education Act ( DSHEA ) of 1994 defines the FDA’s authority in the regulation of dietary supplement products and dietary ingredients. See AgencyIQ’s deep dive into kratom research and regulation here. ]

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The Pharma Data

DECEMBER 15, 2020

In late 2020, the effort received $200,000 in seed funding from the Baker Department of Cardiometabolic Health at the University of Melbourne’s medical school. The researchers regulated the abnormal immunological memory processes found in these patients. The human monoclonal antibody targets specific immune plasma cells.

Disease 52

Disease Clinical Trials Small Molecule Trials 52

KIF1A

MAY 31, 2024

In addition to her role as Chief of the Department of Pediatrics, Dr. Chung serves as the Mary Ellen Avery Professor at Harvard Medical School (HMS), and President of the Children’s Hospital Pediatric Associates. Chung Chief of the Department of Pediatrics.

Treatment 52

Treatment Small Molecule International Research 52

The Pharma Data

AUGUST 16, 2020

Eva Larkai, a fourth-year medical student, led the student group demanding change. A major British medical school is leading the drive to eliminate what it calls “inherent racism” in the way doctors are trained in the UK. And he says the problem is one that all UK medical schools and the wider NHS share.

Medical Schools 52

Medical Schools Doctors Drug Trials Government 52

Broad Institute

AUGUST 7, 2023

A surprising new role for a major immune regulator By Tom Ulrich August 7, 2023 Breadcrumb Home A surprising new role for a major immune regulator By Anne Trafton, MIT News August 7, 2023 Credit: RCSB Protein Data Bank A model of the human STING protein.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Broad Institute

NOVEMBER 20, 2024

Scientists find a region of the mouse gut tightly regulated by the immune system By Allessandra DiCorato November 20, 2024 Breadcrumb Home Scientists find a region of the mouse gut tightly regulated by the immune system A spatial map of gene expression across the intestine reveals the organ’s remarkable adaptability.

Regulations 84

Regulations Immune Response Molecular Biology Disease 84

Policy Prescription

OCTOBER 22, 2024

Rome, MD, MPH Author Affiliations: Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts (Lalani, Hwang, Kesselheim, Rome); Harvard Medical School, Boston, Massachusetts (Lalani, Hwang, Kesselheim, Rome).

Online Pharmacies 113

Online Pharmacies Pharmacy Drugs FDA Approval 113

Broad Institute

AUGUST 14, 2023

A second Cell paper showed how certain mutations drive cancer by modifying the activity and regulation of key proteins. Pan-Cancer analysis of post-translational modifications reveals shared patterns of protein regulation. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center. Online August 14, 2023.

DNA 98

DNA RNA Regulations Treatment 98

KIF1A

MAY 4, 2024

During her time as an undergraduate student, she conducted research on proline metabolism and its effects on ATF4 regulation. Her undergraduate research focused on lipid metabolism of NASH at UCSD Medical School and DNA breakage and repair mechanism at Scripps Research. She graduated from UC San Diego with a B.S.

Science 116

Science Medical Schools Research RNA 116

Drug Target Review

MAY 16, 2024

Further, microbial metabolites contribute importantly to immune system regulation, which impacts cellular and immunological homeostasis. 5 Selected SCFAs accomplish this by acting as histone deacetylase inhibitors (HDACi), by regulating central signalling pathways of cellular growth and death in a variety of cell types and organs (e.g.,

Disease 64

Disease Therapies Medical Schools Treatment 64

Broad Institute

JULY 28, 2023

is joint professor of Neurology, Harvard Medical School at Children's Hospital Boston, and professor of Molecular and Cellular Biology at Harvard’s Center for Brain Science. Yang-Yu Liu & Jakob Hartmann, MGB/Harvard Medical School/McLean Hospital Yang-Yu Liu Yang-Yu Liu Yang-Yu Liu , Ph.D. earned his Ph.D.

Medical Schools 52

Medical Schools Hospitals Regulations Research 52

Broad Institute

AUGUST 7, 2024

At the Broad, he directs the Cancer Genome Computational Analysis Group , and he is a professor of pathology at Harvard Medical School and director of bioinformatics at Massachusetts General Hospital. He is also an associate professor of psychiatry at Massachusetts General Hospital and Harvard Medical School.

Medical Schools 90

Medical Schools Hospitals Bioinformatics Vaccine 90

The Pharma Data

MAY 14, 2021

By offering you another natural option, they are going against everything they have been taught during and since medical school and much of what the medical industry stands for…. While most of the focus is on the pancreas, as that’s the organ that produces insulin and plays a major role in regulating erratic blood levels….

Doctors 52

Doctors Production Medical Schools Pharma Companies 52

The Pharma Data

APRIL 12, 2022

Dana-Farber Cancer Institute, assistant professor of medicine at Harvard Medical School. The BCL-2 family of proteins are known regulators of the apoptosis pathway.3 . “Data obtained from this exploratory analysis holds promise for potential future clinical research,” said Jacqueline S. Garcia, M.D.,

Medical Schools 52

Medical Schools Trials Disease Clinical Development 52

PLOS: DNA Science

SEPTEMBER 21, 2023

Two compelling talks will be “Long Noncoding RNAs as Key Regulators of Mood in Women,” from Orna Issler at the Neuroscience Institute at NYU Langone, and “Advising the US Congress and Policymakers on Issues Related to Pathogen Genomics, ” from Sarah Harvey, from the US Government Accountability Office.

DNA 52

DNA Science Medical Schools Government 52

The Pharma Data

JULY 21, 2021

Health equity is not only accessible healthcare for patients, but developing educational and professional opportunities to create a diverse pipeline of educators, clinicians and other professionals, as well as ensuring all are included in clinical studies,” said Valerie Montgomery Rice, MD, President and CEO, Morehouse School of Medicine.

Medical Schools 52

Medical Schools Clinical Trials Trials Science 52

Codon

JUNE 26, 2023

plasmidsaurus @arjunrajlab (Regulation in biology is incredible. Scientists from the Cincinnati Zoo and Harvard Medical School used AAV9 to deliver and express a gene encoding the AMH hormone in six cats. And complicated.) Codon Prize Winner #3: BioConceptVec Explorer A project by Daniel George, Shrey Joshi, and Shahar Bracha.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

plasmidsaurus @arjunrajlab (Regulation in biology is incredible. Scientists from the Cincinnati Zoo and Harvard Medical School used AAV9 to deliver and express a gene encoding the AMH hormone in six cats. And complicated.) Codon Prize Winner #3: BioConceptVec Explorer A project by Daniel George, Shrey Joshi, and Shahar Bracha.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Agency IQ

NOVEMBER 20, 2023

During an annual update on the program and its various workstreams, regulators and researchers discussed ongoing projects at Sentinel, its work under the current Prescription Drug User Fee authorization (PDUFA) program and next steps in using active surveillance for regulatory purposes. DARWIN EU).

Science 40

Science FDA Research Regulations 40

Codon

OCTOBER 6, 2024

However, in a recent study using sheep , a team at the University of Michigan Medical School found that a nitric-oxide-rich ECMO circuit allowed them to operate an artificial womb without blood thinners. It remains to be seen how data generated this way might be regarded by regulators.

FDA 121

FDA Hospitals Engineering Research 121

Broad Institute

NOVEMBER 21, 2024

said study senior author Brad Bernstein , an institute member at Broad and director of the Gene Regulation Observatory at Broad. “We DOI: 10.1038/s43018-024-00865-3 Tags: Gene Regulation Observatory Cancer Brad Bernstein “We did this study because we wanted to know: How do IDH mutations lead to a fast-growing tumor? Nature Cancer.

Research 124

Research Medical Schools DNA Hospitals 124

Drug Target Review

APRIL 25, 2025

Standard approaches to moving a drug through the development pathway often dont apply or cannot be readily adapted, so you must be both creative and persistent to pave a new adjacent path that regulators will accept. In medical school and during residency, I was exposed to my share of chauvinism and disrespect purely based on sex.

Clinical Development 52

Clinical Development Drug Development Clinical Trials Trials 52

Drug & Device Law

DECEMBER 29, 2023

Indeed, even the weird alternatives the plaintiff advocated, such as “point of sale” signs and DTC advertising (assuming these were Prop 65 remedies at all), were still FDA-regulated labeling. Alcozar didn’t buy it, since the particular regulations did not even apply to the clinics and health care providers that plaintiffs were targeting.

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Testimonials Drugs FDA Vaccine 105