Broad Institute

JUNE 18, 2024

By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples. The researchers also adapted SHINE to distinguish between different flu strains.

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Virus RNA Medical Schools Laboratories 144

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. The study appears in Nature Biotechnology.

RNA 98

RNA Medical Schools Engineering DNA 98

Broad Institute

MARCH 8, 2024

Little is known about what pathogens cause these infections, and so these “non-malarial febrile illnesses” (NMFI) often fly under the radar of infectious disease surveillance programs because researchers don’t know which pathogens to look for. Tags: Infectious Disease DNA sequencing RNA sequencing Nature Communications.

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Research Disease Medical Schools RNA 111

Broad Institute

AUGUST 19, 2024

A team of researchers at the Broad Institute of MIT and Harvard; the Ragon Institute of Mass General Brigham, MIT, and Harvard; and St. Jude Children’s Research Hospital have discovered that oleic acid, one of the most abundant fatty acids in the body, restores a healthy balance of vaginal microbes in a laboratory model of BV.

Hospitals 121

Hospitals Medical Schools Treatment Science 121

Drug Target Review

AUGUST 28, 2024

We then incubate the cells to mature into ‘pro-regenerative’ macrophages and insert two RNA messages to produce two human proteins that will be expressed at the site of injury when these ‘engineered’ macrophages are given back to the patient. The patient’s own monocytes, a type of white blood cell, are removed via an apheresis procedure.

Therapies 114

Therapies Disease Engineering Medical Schools 114

KIF1A

MAY 4, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In this week’s article, researchers in Brazil identified a KIF1A mutation in a cohort of patients with congenital ataxia.

Science 116

Science Medical Schools RNA Research 116

Drug Discovery World

APRIL 16, 2023

According to Sullivan, a technical limitation of the neoantigen vaccine approach is that it is based on DNA and RNA sequencing of tumour tissue, therefore it may not be applicable to patients with earlier-stage disease, whose tumours may be smaller and not provide enough tissue.

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Vaccine Immune Response Medical Schools Trials 130

Drug Target Review

AUGUST 16, 2024

After medical school and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I joined the pharmaceutical industry to leverage my passion and hands-on clinical experience to care for people all over the world by bringing a unique perspective to drug and device research and development.

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Medical Schools Nurses Research Production 106

Drug Target Review

JUNE 6, 2023

Difficult-to-treat and rare, complicated cancers remain a perplexing challenge for IO researchers. Research has shown that these immune system proteins have the ability to trigger anti-cancer immune pathways. Currently he is Alkermes’ Oncology Fellow and Head of a Oncology Preclinical Research at the company. References: M; LWR.

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Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

The Pharma Data

DECEMBER 13, 2020

Dr. Zhang has around 20 years of experience in research and drug development in both industry and academia in the US. Prior to that, he held various oncology research and development positions at Merrimack Pharmaceuticals and Archemix. Dr. Zhang completed his postdoctoral fellowship at Harvard Medical School/Boston Children’s Hospital.

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Medical Schools Clinical Development Hospitals RNA 40

PLOS: DNA Science

JULY 27, 2023

I tracked the numbers of sequenced SARS-CoV-2 genomes posted at GISAID every few days during the pandemic, contributed by researchers everywhere. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages. Right now it’s just below 16 million variations of the tiny genome.

Disease 68

Disease DNA Virus RNA 68

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

Bioinformatics 287

Bioinformatics Pharmacogenetics RNA Medical Schools 287

The Pharma Data

DECEMBER 5, 2020

5, 2020 — A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients’ bone marrow cells, researchers report. SATURDAY, Dec.

Therapies 52

Therapies Disease Medical Schools Virus 52

Broad Institute

MARCH 6, 2024

Related news New project aims to map cellular variation in the healthy human brain Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schizophrenia and from older adults. “To

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Medical Schools RNA Science Research 134

Drug Discovery World

DECEMBER 26, 2023

Representing a dominant field of drug discovery, it isn’t surprising that breakthroughs in cancer research were popular with DDW readers in 2023, particularly strategies to overcome treatment resistance and prevent the spread of disease.

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Clinical Trials Vaccine RNA Trials 162

Broad Institute

JANUARY 30, 2024

More bottles on the medicine shelf would help, but Bhattacharyya, who’s now also a research scientist, realized that science might lead to better tools for diagnosing and treating such challenging cases. Bhattacharyya originally wanted to become a fiction writer, but during high school, his fascination with science became a stronger pull.

Hospitals 137

Hospitals Medical Schools Virus Science 137

Broad Institute

AUGUST 31, 2023

By Leah Eisenstadt August 31, 2023 Credit: Susanna Hamilton, Broad Communications Researchers studied the effects of a schizophrenia gene mutation in different regions of the mouse brain. One of these is the GRIN2A gene, which encodes a subunit of a protein complex called the NMDA receptor.

RNA 143

RNA Medical Schools Research Science 143

Broad Institute

AUGUST 14, 2023

Three studies highlight how proteins are altered in multiple cancer types By Allessandra DiCorato August 14, 2023 Breadcrumb Home Three studies highlight how proteins are altered in multiple cancer types Researchers identify protein modifications that underlie many key cancer processes.

DNA 98

DNA RNA Regulations Medical Schools 98

Broad Institute

SEPTEMBER 28, 2023

Related people Evan Macosko Beth Stevens Most Alzheimer’s disease research on human brain tissue has studied postmortem samples, making it difficult for scientists to discern the earliest events in the brain that might have triggered the buildup of plaques and the death of neurons.

Disease 144

Disease Medical Schools Hospitals Research 144

Broad Institute

DECEMBER 6, 2023

A new, large-scale reference created by researchers at the Broad Institute of MIT and Harvard could help scientists and clinicians better understand the role of cytokines in health and disease. AC: This research could have far-reaching implications, accelerating our understanding of natural immune responses and human immune-related diseases.

Immune Response 138

Immune Response RNA Medical Schools Disease 138

Broad Institute

JUNE 21, 2023

Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane. Typically, studying drug therapies is an expensive and time-consuming undertaking.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

Broad Institute

JUNE 30, 2023

Previous Next To assess LipocyteProfiler, the researchers analyzed white and brown fat cells and liver cells, focusing on traits such as the size, the number, and the location of lipid droplets in a cell. Credit: Phil Kubitz, Claussnitzer lab A merged image showing all of the stained cellular components together.

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105

The Pharma Data

APRIL 22, 2023

” Uncovering cancer immune system suppression: A three-part investigation As the basis of their investigation, the team profiled primary and metastatic lymph node tumours from 14 patients with head and neck squamous cell cancers, using single cell RNA sequencing. Source link: [link]

Medical Schools 40

Medical Schools Hospitals Therapies RNA 40

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. He was bestowed the 2024 NIH HEAL Director’s Trailblazer Award for this work.

Treatment 59

Treatment Clinical Trials Molecular Biology Therapies 59

Broad Institute

JUNE 13, 2023

Although it focused on a rare form of cancer – blastic plasmacytoid dendritic cell neoplasm (BPDCN) – the research may shed light on how other cancers develop, particularly those involving blood or lymph cells that travel the bloodstream to all corners of the body, investigators say.

Hospitals 52

Hospitals Medical Schools Disease Research 52

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. Tell us a bit about your research.

Science 124

Science Medical Schools Hospitals Disease 124

The Pharma Data

NOVEMBER 22, 2020

Their research – the first of its kind – suggests that the system can be utilized to address cancer in animals, according to Professor Dan Peer, whose peer-reviewed research was published in the Science Advances journal. In humans, this technology may be able to extend life expectancy, according to Peer.

DNA 52

DNA Medical Schools RNA Science 52

Codon

JUNE 26, 2023

Goodsell, Scripps Research and RCSB Protein Data Bank. And for another study, researchers engineered bacteriophage T4 to target and deliver payloads to human cells , simply by swapping around the proteins on their outer shells and then coating them in positively-charged lipid molecules. “Every query is like $2.” in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Goodsell, Scripps Research and RCSB Protein Data Bank. And for another study, researchers engineered bacteriophage T4 to target and deliver payloads to human cells , simply by swapping around the proteins on their outer shells and then coating them in positively-charged lipid molecules. “Every query is like $2.” in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

The Pharma Data

DECEMBER 28, 2020

According to The New York Times , polls conducted by Gallup, the Kaiser Family Foundation and the Pew Research Center all show vaccine acceptance rates rising from about 50% this summer to more than 60% and, in one poll, 73%. is so sporadic,” Jeremy Luban, a virologist at the University of Massachusetts Medical School, told the Post.

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Vaccine Government Virus Medical Schools 52