The Pharma Data

AUGUST 16, 2020

Eva Larkai, a fourth-year medical student, led the student group demanding change. A major British medical school is leading the drive to eliminate what it calls “inherent racism” in the way doctors are trained in the UK. And he says the problem is one that all UK medical schools and the wider NHS share.

Medical Schools 52

Medical Schools Doctors Government Drug Trials 52

Drug Discovery World

JUNE 12, 2024

Immune-checkpoint inhibitor (ICI) therapy has transformed treatment outcomes for RCC. Ofer Sharon, CEO of OncoHost, commented: “As we enter the era of precision medicine, validated biomarkers are increasingly used to guide treatment decisions and uncover resistance pathways in various types of tumours.

Protein Expression 130

Protein Expression Medical Schools Treatment Therapies 130

Drug Discovery World

MARCH 7, 2024

Research published in Cell Genomics has shown that prostate cancer includes two different subtypes of the disease, also known as evotypes. This discovery was made by using artificial intelligence (AI) to help unlock new discoveries about the evolution of prostate cancer which could lead to the development of new treatments.

Disease 147

Disease Medical Schools DNA International 147

Drug Target Review

AUGUST 29, 2024

However, these treatments will eventually fail for the majority of patients, so there is a strong need for better CAR therapies. How might the CD5 knockout approach impact the treatment of other types of cancers beyond T-cell lymphoma?

Therapies 59

Therapies Treatment Engineering Molecular Biology 59

Drug Discovery World

OCTOBER 13, 2023

A UK-based study will investigate whether a common anti-viral medication could double up as a treatment for long Covid. Millions have been affected by this terrible condition which makes research like this critically important as we seek to find new ways to improve care.” The post Could a common antiviral treat long Covid?

Medical Schools 147

Medical Schools Hospitals Virus Treatment 147

Drug Discovery World

MARCH 15, 2023

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer. First new treatment in 45 years Lead researcher Dr Darrell Green, from UEA’s Norwich Medical School, was inspired to study childhood bone cancer after his best friend died from the disease as a teenager.

Small Molecule 130

Small Molecule Medical Schools Drugs Clinical Trials 130

Drug Discovery World

NOVEMBER 8, 2023

While traditional approaches to clinical trials have helped us manage some of these conditions to a certain extent, they alone may not provide us the velocity we need to accelerate the research and conquer these diseases, raising the possibility that technologies such as artificial intelligence (AI) may hold the answer.

Clinical Trials 182

Clinical Trials Trials Disease Medical Schools 182

Drug Discovery World

MAY 8, 2024

“No medication has been approved by the FDA for vaping cessation in the United States,” said lead author Nancy Rigotti, Director of Massachusetts General Hospital’s Tobacco Research and Treatment Center and a Professor of Medicine at Harvard Medical School. For cytisinicline treatment compared to placebo, 31.8%

Clinical Trials 182

Clinical Trials Trials Compliance Drugs 182

Broad Institute

JANUARY 25, 2024

This could potentially help with disease prevention — if we know from someone’s retinal image that they are at high risk of developing glaucoma or cardiovascular disease in the future, we could refer them for follow-up screening or preventative treatment.”

Disease 124

Disease Research Medical Schools Science 124

Drug Discovery World

MAY 4, 2023

New research in mice has identified how gut bacteria alter the body’s response to PD-1 checkpoint blockade immunotherapy, currently used for the treatment of 25 forms of cancer. The findings could inform the design of treatments that boost the efficacy of cancer immunotherapy among patients with suboptimal response.

Medical Schools 130

Medical Schools Small Molecule Research Treatment 130

Drug Discovery World

FEBRUARY 6, 2024

Catherine Brownstein is an Assistant Professor in Pediatrics at Harvard Medical School and the Assistant Director of the Molecular Genetics Core Facility at Boston Children’s Hospital. Researchers gain insights into the latest trends, methodologies, and discoveries shaping the field.

Medical Schools 147

Medical Schools Clinical Trials Assay Development Hospitals 147

Drug Discovery World

NOVEMBER 28, 2023

The peer-reviewed article titled ‘Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease (PD) mouse model’ was the result of collaborative work between Cambridge University, Harvard Medical School, and Mission Therapeutics. Mission is planning to initiate a MTX325 Phase I trial in humans in early 2024.

Disease 130

Disease Therapies Medical Schools Trials 130

Broad Institute

MARCH 8, 2024

Little is known about what pathogens cause these infections, and so these “non-malarial febrile illnesses” (NMFI) often fly under the radar of infectious disease surveillance programs because researchers don’t know which pathogens to look for. What implications do your findings have for diagnosis, surveillance, and treatment?

Research 111

Research Disease Medical Schools RNA 111

Broad Institute

DECEMBER 20, 2023

In a study appearing in Nature , the researchers showed that these compounds could kill methicillin-resistant Staphylococcus aureus (MRSA) grown in a lab dish and in two mouse models of MRSA infection. This knowledge could help researchers to design additional drugs that might work even better than the ones identified by the model.

Research 111

Research Engineering Medical Schools Science 111

Drug Discovery World

JANUARY 5, 2023

CANbridge Pharmaceuticals has exercised its option to secure the exclusive global rights to develop, manufacture and commercialise a novel gene therapy to treat spinal muscular atrophy (SMA) from UMass Chan Medical School. . It also exhibited much less liver toxicity when administered intravenously. .

Therapies 130

Therapies Medical Schools Clinical Development Pharmaceuticals 130

Drug Discovery World

FEBRUARY 2, 2023

The first and only treatment specifically indicated for patients with ESR1 mutations in ER+, HER2- advanced or metastatic breast cancer has been approved in the US.

FDA Approval 130

FDA Approval Therapies FDA Medical Schools 130

Broad Institute

AUGUST 19, 2024

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections.

Hospitals 121

Hospitals Medical Schools Treatment Science 121

Broad Institute

JUNE 18, 2024

Now researchers have developed a low-cost paper strip test that could allow more patients to find out which type of flu they have and get the right treatment. Myhrvold, who is currently an assistant professor at Princeton University, was a postdoctoral researcher in Sabeti’s lab when the study began.

Virus 144

Virus RNA Medical Schools Laboratories 144

Drug Discovery World

APRIL 16, 2023

The mainstays of curative therapies for early-stage HCC include surgical resection and thermal ablation, a treatment that destroys the cancer cells with heat or cold. Patients who received the combination treatment had their risk of recurrence or death reduced by 28% compared with patients in the active surveillance arm.

Therapies 130

Therapies Medical Schools Trials Treatment 130

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. The study appears in Nature Biotechnology.

RNA 98

RNA Medical Schools Engineering DNA 98

Drug Discovery World

OCTOBER 26, 2022

The researchers also showed that H84T BanLec protected mice from getting infected by the flu virus. . Better flu treatments are desperately needed,” added Markovitz. The genetically engineered version has been called H84T and worked against the viruses that cause AIDS, hepatitis C and influenza in tests in tissue and blood samples.

Engineering 130

Engineering Virus Medical Schools International 130

biobide

FEBRUARY 2, 2024

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. How can research boost the discovery of specific therapies for childhood and adolescent cancers? This treatment was developed by performing a chemical screening on zebrafish.

Disease 59

Disease Medical Schools Pharma Companies Clinical Trials 59

Drug Target Review

SEPTEMBER 14, 2023

Dr Cristina Ureche from Hannover Medical School (MHH) guides us through the aseptic process of viral vector-based vaccines, and Dr Mark J. Steve O’Keeffe of Angry@Arthritis and Dr Ivan Martin of the University of Basel lead the charge in revolutionizing osteoarthritis treatment through innovative regenerative approaches.

Vaccine 105

Vaccine Medical Schools Drugs Therapies 105

Drug Target Review

AUGUST 28, 2024

What are the main challenges currently faced in the treatment of chronic liver diseases, and how does Resolution Therapeutics aim to address these challenges? Dr Brass has published over 85 peer reviewed articles and more than 200 abstracts, primarily in the field of hepatology, in both the areas of clinical and basic science research.

Therapies 114

Therapies Disease Engineering Medical Schools 114

Broad Institute

JUNE 28, 2023

But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply a side effect of cancer cells’ fast growth. The findings, published today in Nature , could lead to new ways of guiding cancer treatment or developing targeted drugs. Such large-scale changes in DNA have been difficult to study.

DNA 122

DNA Medical Schools Treatment Research 122

Drug Discovery World

JANUARY 8, 2024

Importantly, regulatory guidelines facilitate this, allowing us to use highly translatable animal model data to complement leaner clinical trials in support of registration,” said Michael Lobritz, Head of Infectious Diseases, Roche Pharma Research and Early Development (pRED). baumannii has reached patients in over 50 years.

Clinical Trials 130

Clinical Trials Government Drugs Trials 130

Drug Discovery World

APRIL 23, 2024

Valera, an Associate Professor of Psychiatry at Harvard University and a leading researcher on traumatic brain injuries among survivors of domestic violence, estimated that while hundreds of concussions occur in the NFL each year, there could be nearly 1.6 In a March 2022 report by the New York Times, Eve M.

Therapies 147

Therapies Drugs Laboratories Medical Schools 147

The Pharma Data

MAY 17, 2021

These initiatives could support insurance coverage of previously off-label uses, prevent costly new drugs from inappropriately receiving preferential regulatory treatment that is intended for drugs with no FDA-approved alternatives, and better inform clinicians by providing evidence-based information about how drugs should be used,” they noted. .

Research 52

Research FDA Approval Packaging FDA 52

Broad Institute

NOVEMBER 13, 2023

Liquid biopsies enable clinicians to find and analyze tumor DNA in a patient’s blood sample to detect cancer early, monitor cancer recurrence, assess the patient’s response to treatment, and measure other clinically important features in real time, without invasive procedures. Gerstner, Jr.,

DNA 116

DNA Medical Schools Treatment Therapies 116

The Pharma Data

JUNE 2, 2023

With only one currently approved treatment option, I see HS patients with a tremendous need for alternatives that reduce the disabling physical symptoms of HS, improve the emotional burden and help partially avoid invasive surgery, if treating early,” said Professor Christos C. Find out more at [link].

Medical Schools 52

Medical Schools Treatment Disease Therapies 52

The Pharma Data

SEPTEMBER 7, 2021

The first patients have been enrolled in a phase 1 randomized placebo-controlled clinical trial to study a therapeutic vaccine for opioid use disorder developed by researchers at the University of Minnesota Medical School. The study plans to enroll up to 45 volunteers. The total project cost is financed with federal dollars.

Clinical Trials 52

Clinical Trials Vaccine Trials Medical Schools 52

Drug Target Review

JULY 13, 2023

Drug discovery is a complex and vital field that continually seeks to identify new therapeutic targets and develop effective treatments. In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development.

Disease 98

Disease Small Molecule Cell Biology Medical Schools 98

Advarra

FEBRUARY 28, 2023

Rebecca Lee Crumpler Rebecca Lee Crumpler was one of the first African American women to graduate from medical school and to practice medicine. Crumpler’s focus on the care of women and children and her dedication to research led her to publish “A Book of Medical Discourses” in 1883. and abroad.

Medical Schools 52

Medical Schools Laboratories Clinical Research Treatment 52

Drug Target Review

FEBRUARY 26, 2024

Rather than solely identifying tumour-associated mutations which can be specifically targeted for effective treatment, we now need to consider how non-mutational events play into both the development of the primary tumour and the development of therapy resistance.

Therapies 59

Therapies Molecular Biology Regulations Medical Schools 59

On Medicine

APRIL 6, 2023

This inaugural conference was jointly sponsored by Sofia’s Hope, the Cincinnati Children’s Heart Institute, and Oishei Children’s Hospital/Jacobs School of Medicine and Biomedical Sciences, University at Buffalo. The “ Cardio-Oncology Journal Prize” for top original research posters was sponsored by BMC. Elizabeth (Lieke) A.M.

Medical Schools 52

Medical Schools Hospitals International Treatment 52

The Pharma Data

DECEMBER 3, 2020

They conducted the research with colleagues at the Barcelona Beta Research Centre in Spain, the University Medical Centre in Ljubljana, Slovenia, and the University of Paris. They published their research in the journal Alzheimer’s & Dementia. They published their research in the journal The Laryngoscope.

Disease 52

Disease Research Virus Hospitals 52

Drug Discovery World

APRIL 16, 2023

The association between this treatment approach and TMB will be further explored in upcoming studies. The vaccine-pembrolizumab combination led to a similar reduction in the risk of recurrence or death in patients with high and low TMB (35% and 41%, respectively).

Vaccine 130

Vaccine Immune Response Medical Schools Trials 130