Broad Institute

JUNE 18, 2024

By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples. Then, in 2022, they began adapting the assay to detect other viruses they knew were always circulating: influenzas.

Virus 144

Virus RNA Medical Schools Laboratories 144

Drug Target Review

AUGUST 28, 2024

We then incubate the cells to mature into ‘pro-regenerative’ macrophages and insert two RNA messages to produce two human proteins that will be expressed at the site of injury when these ‘engineered’ macrophages are given back to the patient. The patient’s own monocytes, a type of white blood cell, are removed via an apheresis procedure.

Therapies 114

Therapies Disease Engineering Medical Schools 114

Drug Discovery World

MARCH 21, 2023

“We believe we have developed the first technology to design an organism that can’t be infected by any known virus,” said the study’s first author, Akos Nyerges, research fellow in genetics in the lab of George Church in the Blavatnik Institute at Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering. “We

Engineering 130

Engineering Virus Research Medical Schools 130

Broad Institute

AUGUST 19, 2024

Using RNA sequencing and working with the Broad’s Metabolomics Platform and collaborators at St. I’m so proud of this team and the partnership we formed to follow the science and set up some major positive impacts on women’s health,” Blainey said.

Hospitals 121

Hospitals Medical Schools Treatment Science 121

Drug Discovery World

APRIL 16, 2023

According to Sullivan, a technical limitation of the neoantigen vaccine approach is that it is based on DNA and RNA sequencing of tumour tissue, therefore it may not be applicable to patients with earlier-stage disease, whose tumours may be smaller and not provide enough tissue.

Vaccine 130

Vaccine Immune Response Medical Schools Trials 130

KIF1A

MAY 4, 2024

Later, she developed an interest in the RNA world, specifically focusing on alternative splicing and its correlation with neuron cell properties within and across cell types. Her undergraduate research focused on lipid metabolism of NASH at UCSD Medical School and DNA breakage and repair mechanism at Scripps Research.

Science 116

Science Medical Schools RNA Research 116

Broad Institute

MARCH 8, 2024

First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad. Tags: Infectious Disease DNA sequencing RNA sequencing Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing. Nature Communications.

Research 111

Research Disease Medical Schools RNA 111

Drug Target Review

AUGUST 16, 2024

After medical school and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I graduated with my BS in physiology and later attended the University of Michigan Medical School.

Medical Schools 106

Medical Schools Nurses Research Production 106

The Pharma Data

DECEMBER 13, 2020

Dr. Zhang completed his postdoctoral fellowship at Harvard Medical School/Boston Children’s Hospital. Prior to that, he held various oncology research and development positions at Merrimack Pharmaceuticals and Archemix. He received his B.S. degree from Henan Normal University, M.S. degree from Chinese Academy of Sciences and Ph.D.

Medical Schools 40

Medical Schools Clinical Development Hospitals RNA 40

Drug Target Review

JUNE 6, 2023

Delivery of therapy is being evaluated through injections of DNA and RNA encoding IL-12, viral vectors, and other exploratory platforms designed to bring IL-12 in close proximity to the tumour and avoid excessive IL-12 in systemic circulation. Some approaches have already reached the clinical trial stage, with others not far behind.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

PLOS: DNA Science

JULY 27, 2023

Harvard Medical School researchers recently described an “AI tool” that “Decodes Brain Cancer’s Genome During Surgery,” in the journal Med. But, they have genomes, built of RNA or DNA. I was in graduate school for my PhD in genetics when the first virus genome sequences were published.

Disease 68

Disease DNA Virus RNA 68

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

Bioinformatics 288

Bioinformatics Pharmacogenetics RNA Medical Schools 288

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A.

Therapies 52

Therapies Disease Medical Schools Virus 52

Broad Institute

MARCH 6, 2024

Related news New project aims to map cellular variation in the healthy human brain Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schizophrenia and from older adults.

Medical Schools 134

Medical Schools RNA Science Research 134

Drug Discovery World

DECEMBER 26, 2023

Scientists from the Chemistry and Biochemistry Departments at the University of Liverpool and Nanjing Medical School in China discovered a possible way to block proteins that cause metastasis. Purple Biotech shared the new results at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Florida, US.

Clinical Trials 163

Clinical Trials Vaccine RNA Trials 163

Broad Institute

AUGUST 31, 2023

We were surprised to see that just missing one copy of this gene can induce many changes at the RNA level, at the protein level, at the functional level, and at the behavioral level,” said Farsi. The scientists also found reduced levels of an enzyme that degrades dopamine, providing further evidence for dopamine’s role in the disorder.

RNA 143

RNA Medical Schools Research Science 143

Broad Institute

JANUARY 30, 2024

He saw how genomic technology had progressed during the seven years he’d spent in medical school, spawning discoveries like new mutations underlying leukemia, and he wanted to bring the same capabilities to the study of infectious disease.

Hospitals 137

Hospitals Medical Schools Virus Science 137

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

DNA 98

DNA RNA Regulations Medical Schools 98

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. Tags: Cell Circuits Program Immunology RNA sequencing The reference, called the Immune Dictionary , appears today in Nature. Online December 6, 2023.

Immune Response 138

Immune Response RNA Medical Schools Disease 138

Broad Institute

SEPTEMBER 28, 2023

Beth Stevens , an institute member at the Broad, an associate professor at Harvard Medical School, and a research associate in neurobiology at Boston Children’s Hospital, was a co-author on the study as well.

Disease 144

Disease Medical Schools Hospitals Research 144

Broad Institute

JUNE 21, 2023

Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools RNA 52

Broad Institute

JUNE 30, 2023

Related Articles Study finds how a genetic variant raises diabetes risk through an unexpected mechanism Related People Anne Carpenter Melina Claussnitzer Related programs Imaging Platform Metabolism Program Novo Nordisk Foundation Center for Genomic Mechanisms of Disease The field of microscopy has advanced immensely over the last fifty years in its (..)

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105

The Pharma Data

APRIL 22, 2023

” Uncovering cancer immune system suppression: A three-part investigation As the basis of their investigation, the team profiled primary and metastatic lymph node tumours from 14 patients with head and neck squamous cell cancers, using single cell RNA sequencing.

Medical Schools 40

Medical Schools Hospitals Therapies RNA 40

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. He was bestowed the 2024 NIH HEAL Director’s Trailblazer Award for this work.

Treatment 59

Treatment Clinical Trials Molecular Biology Therapies 59

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science 124

Science Medical Schools Hospitals Disease 124

Broad Institute

JUNE 13, 2023

To better understand this process, researchers did a deep dive into the genetics of patients' bone marrow, blood, and skin leukemia cells – sequencing the DNA and RNA in individual cells. "We

Hospitals 52

Hospitals Medical Schools Disease Research 52

The Pharma Data

NOVEMBER 22, 2020

. “Operationally, you design a stretch of 20 [nucleotide] base pairs that match a gene that you want to edit,” George Church, a professor of genetics at Harvard Medical School, told the news source. Once the DNA has been cut, the cell’s natural repair mechanisms kick in.

DNA 52

DNA Medical Schools RNA Science 52

PLOS: DNA Science

FEBRUARY 29, 2024

But maternal genetic information, in the form of messenger RNA “transcripts,” still guides development. Acceptance into (a) preschool (b) college or (c) medical school; marriage; a career begins; when grown offspring leave home. Cleavage divisions ensue. Social milestones. My answer? #14.

DNA 77

DNA Medical Schools Science RNA 77

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

The Pharma Data

DECEMBER 23, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. is so sporadic,” Jeremy Luban, a virologist at the University of Massachusetts Medical School, told the Post. “It may very well be here. The sequencing in the U.S.

Vaccine 52

Vaccine Government Virus Medical Schools 52

The Pharma Data

DECEMBER 28, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. is so sporadic,” Jeremy Luban, a virologist at the University of Massachusetts Medical School, told the Post. “It may very well be here. The sequencing in the U.S.

Vaccine 52

Vaccine Government Medical Schools Virus 52