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By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples. Then, in 2022, they began adapting the assay to detect other viruses they knew were always circulating: influenzas.
Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts MedicalSchool (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs.
The method, called Genotypic and Phenotypic Antibiotic Susceptibility Testing through RNA detection, or GoPhAST-R, analyzes the growth and genetic activity of the bacteria to quickly determine the pathogen’s susceptibility to various medicines.
We were surprised to see that just missing one copy of this gene can induce many changes at the RNA level, at the protein level, at the functional level, and at the behavioral level,” said Farsi. The scientists also found reduced levels of an enzyme that degrades dopamine, providing further evidence for dopamine’s role in the disorder.
In the new work, the team used two single-cell RNA sequencing methods to analyze 67 metastatic breast cancer biopsies collected from 60 different patients. Methods matchup Metastatic breast cancer, which has spread from the breast to other areas of the body, remains incurable and is less well understood than breast cancer that hasn’t spread.
By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.
Using RNA sequencing and working with the Broad’s Metabolomics Platform and collaborators at St. I’m so proud of this team and the partnership we formed to follow the science and set up some major positive impacts on women’s health,” Blainey said.
Later, she developed an interest in the RNA world, specifically focusing on alternative splicing and its correlation with neuron cell properties within and across cell types. Her undergraduate research focused on lipid metabolism of NASH at UCSD MedicalSchool and DNA breakage and repair mechanism at Scripps Research.
The method, called Genotypic and Phenotypic Antibiotic Susceptibility Testing through RNA detection, or GoPhAST-R, analyzes the growth and genetic activity of the bacteria to quickly determine the pathogen’s susceptibility to various medicines.
Beth Stevens , an institute member at the Broad, an associate professor at Harvard MedicalSchool, and a research associate in neurobiology at Boston Children’s Hospital, was a co-author on the study as well.
He saw how genomic technology had progressed during the seven years he’d spent in medicalschool, spawning discoveries like new mutations underlying leukemia, and he wanted to bring the same capabilities to the study of infectious disease.
First author Zoë Levine is an MD-PhD candidate at Harvard MedicalSchool and graduate student in the lab of Pardis Sabeti at the Broad. Tags: Infectious Disease DNA sequencing RNA sequencing Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing. Nature Communications.
In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.
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After medicalschool and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I graduated with my BS in physiology and later attended the University of Michigan MedicalSchool.
Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.
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Harvard MedicalSchool researchers recently described an “AI tool” that “Decodes Brain Cancer’s Genome During Surgery,” in the journal Med. But, they have genomes, built of RNA or DNA. I was in graduate school for my PhD in genetics when the first virus genome sequences were published.
. “Operationally, you design a stretch of 20 [nucleotide] base pairs that match a gene that you want to edit,” George Church, a professor of genetics at Harvard MedicalSchool, told the news source. Once the DNA has been cut, the cell’s natural repair mechanisms kick in.
Dr. Zhang completed his postdoctoral fellowship at Harvard MedicalSchool/Boston Children’s Hospital. Prior to that, he held various oncology research and development positions at Merrimack Pharmaceuticals and Archemix. He received his B.S. degree from Henan Normal University, M.S. degree from Chinese Academy of Sciences and Ph.D.
Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane.
Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. He was bestowed the 2024 NIH HEAL Director’s Trailblazer Award for this work.
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To better understand this process, researchers did a deep dive into the genetics of patients' bone marrow, blood, and skin leukemia cells – sequencing the DNA and RNA in individual cells. "We
A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.
A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.
Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. Tags: Cell Circuits Program Immunology RNA sequencing The reference, called the Immune Dictionary , appears today in Nature. Online December 6, 2023.
We then incubate the cells to mature into ‘pro-regenerative’ macrophages and insert two RNA messages to produce two human proteins that will be expressed at the site of injury when these ‘engineered’ macrophages are given back to the patient. The patient’s own monocytes, a type of white blood cell, are removed via an apheresis procedure.
Isselbacher Professor of Medicine at Harvard MedicalSchool, director of the Center for Computational and Integrative Biology and member of the Department of Molecular Biology at MGH, and co-director of the Center for Microbiome Informatics and Therapeutics at MIT.
Scientists at the Broad Institute of MIT and Harvard, Harvard MedicalSchool, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntingtons disease leads to the death of brain cells. Funding This work was supported by CHDI Foundation, Inc.,
Dr. Cheruiyot is a post-doctoral fellow at the Joslin Diabetes Center, Harvard MedicalSchool (HMS) I n the lab of Dr. Jean Schaffer, s he studies molecular mechanisms underlying protein synthesis in pancreatic beta cells, and alterations of such mechanisms in diabetes.
At the Broad, Rehm wears many hats: chief medical officer for Broad Clinical Labs, a co-leader of Broads Center for Mendelian Genomics , and head of the Translational Genomics Group , a research effort that aims to understand the genetic basis of rare disease.
But maternal genetic information, in the form of messenger RNA “transcripts,” still guides development. Acceptance into (a) preschool (b) college or (c) medicalschool; marriage; a career begins; when grown offspring leave home. Cleavage divisions ensue. Social milestones. My answer? #14.
One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. is so sporadic,” Jeremy Luban, a virologist at the University of Massachusetts MedicalSchool, told the Post. “It may very well be here. The sequencing in the U.S.
One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. is so sporadic,” Jeremy Luban, a virologist at the University of Massachusetts MedicalSchool, told the Post. “It may very well be here. The sequencing in the U.S.
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