The Pharma Data

DECEMBER 13, 2020

Their extensive experience and proven track record in advancing innovative therapies, in addition to strong leadership skills, will help us to strengthen our portfolio and accelerate technology translation to help patients in need.”. Dr. Zhang completed his postdoctoral fellowship at Harvard Medical School/Boston Children’s Hospital.

Medical Schools 40

Medical Schools Clinical Development Therapies RNA 40

The Pharma Data

APRIL 22, 2023

” Uncovering cancer immune system suppression: A three-part investigation As the basis of their investigation, the team profiled primary and metastatic lymph node tumours from 14 patients with head and neck squamous cell cancers, using single cell RNA sequencing. Source link: [link]

Medical Schools 40

Medical Schools Therapies Treatment Hospitals 40

Broad Institute

JUNE 21, 2023

Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane. Typically, studying drug therapies is an expensive and time-consuming undertaking.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

Drug Target Review

AUGUST 28, 2024

Once a patient develops advanced cirrhosis/end-stage liver disease there are no specific therapies to significantly avoid major decompensations and death in the next few years. Could you describe the platform of macrophage biology and cell engineering used by Resolution Therapeutics in developing their cell therapies?

Therapies 116

Therapies Disease Engineering Medical Schools 116

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. I hope our approach helps scientists make sense of any immune process, vaccine, disease, or therapy response, so that one can infer which cytokines are contributing to it.

Immune Response 138

Immune Response RNA Disease Medical Schools 138

The Pharma Data

DECEMBER 5, 2020

5, 2020 — A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients’ bone marrow cells, researchers report. Both of the new gene therapy studies were published online Dec. SATURDAY, Dec. 5 in the New England Journal of Medicine.

Therapies 52

Therapies Disease Medical Schools Virus 52

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science 124

Science Medical Schools Disease Hospitals 124

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. The study appears in Nature Biotechnology.

RNA 98

RNA Medical Schools Engineering Disease 98

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. Nevertheless, phage therapy did have a stint in the U.S. I’ll post an update soon. coli in mice.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. Nevertheless, phage therapy did have a stint in the U.S. I’ll post an update soon. coli in mice.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Broad Institute

JANUARY 30, 2024

He saw how genomic technology had progressed during the seven years he’d spent in medical school, spawning discoveries like new mutations underlying leukemia, and he wanted to bring the same capabilities to the study of infectious disease.

Hospitals 137

Hospitals Virus Medical Schools Science 137

keypoint

JANUARY 8, 2025

Dr. Cheruiyot is a post-doctoral fellow at the Joslin Diabetes Center, Harvard Medical School (HMS) I n the lab of Dr. Jean Schaffer, s he studies molecular mechanisms underlying protein synthesis in pancreatic beta cells, and alterations of such mechanisms in diabetes.

Medical Schools 59

Medical Schools RNA Laboratories Doctors 59

Elrig

MARCH 10, 2025

The free-to-attend event will bring together scientists, researchers and entrepreneurs from across the drug discovery community working on proteins, RNA, cell and gene therapies, PROTACs, as well as the application of big data to support target identification, biomarkers and the development of big molecules.

Research 52

Research Laboratories Medical Schools Engineering 52

Broad Institute

JANUARY 16, 2025

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntingtons disease leads to the death of brain cells.

Disease 130

Disease DNA Medical Schools RNA 130

Broad Institute

NOVEMBER 6, 2024

We are incredibly grateful to each and every patient who partnered with us, all those involved in their clinical care, and the exceptional team in our lab who made this research possible.” “This work provides a biological foundation for testing more targeted therapies for myocarditis due to an immune checkpoint inhibitor.

Immune Response 125

Immune Response Medical Schools Clinical Trials Treatment 125