Broad Institute

MARCH 6, 2024

Related news New project aims to map cellular variation in the healthy human brain Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schizophrenia and from older adults.

Medical Schools 134

Medical Schools RNA Science Research 134

Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

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DNA RNA Disease Hospitals 128

Drug Target Review

JULY 1, 2024

As a non-opioid, SRP-001 also eliminates abuse potential, positioning it as a safer and effective drug candidate for the treatment of acute and neuropathic pain and migraine headache. How does SRP-001’s safety profile, especially concerning hepatotoxicity and nephrotoxicity, compare to other common pain medications?

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Broad Institute

AUGUST 31, 2023

Finally, we have an animal model with human-genetic validity and robust neurobiological overlap with human patients that can help scientists learn how existing treatments work and potentially help identify new ones,” said first author Zohreh Farsi, a staff scientist in the Sheng lab. “We

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RNA Medical Schools Research Science 143

Drug Target Review

AUGUST 28, 2024

What are the main challenges currently faced in the treatment of chronic liver diseases, and how does Resolution Therapeutics aim to address these challenges? Once a patient develops advanced cirrhosis/end-stage liver disease there are no specific therapies to significantly avoid major decompensations and death in the next few years.

Therapies 114

Therapies Disease Engineering Medical Schools 114

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

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DNA RNA Regulations Treatment 98

Broad Institute

MARCH 8, 2024

Levine and Siddle say that these findings could improve the precision of diagnostics and treatments in areas with high numbers of NMFI cases. First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad. Nature Communications. Online January 25, 2024.

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Research Disease Medical Schools RNA 111

The Pharma Data

APRIL 22, 2023

This latest breakthrough discovery, published in the high impact scientific journal Nature Communications on 27 March 2023, has implications for the development of novel strategies for cancer treatment. “Using a treatment to alleviate stress on immune cells, we found that immune cells were able to kill cancer cells more effectively.

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Medical Schools Therapies Treatment Hospitals 40

Broad Institute

JANUARY 30, 2024

In others, an infection can cause the immune system to spin out of control, leading to sepsis — organ dysfunction that lacks effective treatments and is often fatal. Bhattacharyya’s lab is continuing to explore the cell’s involvement in severe illness to inform new diagnostic and treatment approaches.

Hospitals 137

Hospitals Medical Schools Virus Science 137

The Pharma Data

NOVEMBER 22, 2020

The mice who received the treatment had double the life expectancy as their counterparts, with a 30% higher survival rate. Peer stated that his team plans to develop a treatment for all cancers and that their technique could be ready for humans within the next two years.

DNA 52

DNA Medical Schools RNA Science 52

Broad Institute

SEPTEMBER 28, 2023

Knowing the molecular changes in neurons, glia, and other brain cells around plaques during the early phases of the disease could help scientists design treatments that work best when given early. Macosko knew samples from these living patients presented a rare chance to observe cells exposed to the initial stages of Alzheimer’s pathology.

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Disease Medical Schools Research Hospitals 144

PLOS: DNA Science

JULY 27, 2023

These patterns can foretell which treatments will likely work and which won’t, how likely and quickly the cancer will spread, and its path in the body. Harvard Medical School researchers recently described an “AI tool” that “Decodes Brain Cancer’s Genome During Surgery,” in the journal Med.

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Disease DNA Virus RNA 98

Drug Target Review

JUNE 6, 2023

In this IO arena, we continue to search for additional treatments that can further benefit patients. Immune checkpoint inhibitors, a well-established class of IO treatments, are designed to improve the ability of T-cells to fight cancer by removing inhibitory or suppressive mechanisms that may dampen the anti-cancer functions of T cells.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

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Science Medical Schools Disease Hospitals 124

Broad Institute

JUNE 13, 2023

The results add to our understanding of the development of BPDCN, which is critical to devising new and better treatments for the disease," he continues. To better understand this process, researchers did a deep dive into the genetics of patients' bone marrow, blood, and skin leukemia cells – sequencing the DNA and RNA in individual cells. "We

Hospitals 52

Hospitals Disease Medical Schools Research 52

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A. These new approaches are more subtle than the most advanced experimental gene therapy for sickle cell disease, a treatment developed by U.S.

Therapies 52

Therapies Disease Medical Schools Virus 52

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. For many immune-mediated diseases, there's no cure or treatment. Some patients develop resistance to treatment and we cannot predict who they will be.

Immune Response 138

Immune Response RNA Disease Medical Schools 138

The Pharma Data

DECEMBER 23, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. Moderna and other companies that have worked more closely with Operation Warp Speed to develop their vaccines already receive favored treatment from suppliers, the Times reported.

Vaccine 52

Vaccine Government Virus Medical Schools 52

The Pharma Data

DECEMBER 28, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. Moderna and other companies that have worked more closely with Operation Warp Speed to develop their vaccines already receive favored treatment from suppliers, the Times reported.

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Vaccine Government Virus Medical Schools 52