Broad Institute

OCTOBER 21, 2024

By Leah Eisenstadt October 21, 2024 Credit: Kevin Middleton, Broad Communications In the Bhattacharyya lab, researchers develop methods to quickly identify the most appropriate treatments for bacterial infections. The findings appear in the Journal of Clinical Microbiology.

RNA 115

RNA Hospitals Laboratories Medical Schools 115

Broad Institute

SEPTEMBER 18, 2024

Gram-negative bacteria such as Enterobacteriaceae are a common cause of these infections and have few treatment options. Researchers at Keio University School of Medicine in Tokyo and the Broad Institute of MIT and Harvard have isolated 18 bacterial strains from stool from healthy people that could potentially be a more effective treatment.

Medical Schools 119

Medical Schools Disease Hospitals Treatment 119

Drug Target Review

AUGUST 29, 2024

However, these treatments will eventually fail for the majority of patients, so there is a strong need for better CAR therapies. How might the CD5 knockout approach impact the treatment of other types of cancers beyond T-cell lymphoma?

Therapies 59

Therapies Treatment Engineering Molecular Biology 59

Broad Institute

JUNE 28, 2023

The findings, published today in Nature , could lead to new ways of guiding cancer treatment or developing targeted drugs. Towards treatments In nearly one-third of all cancers in TCGA, one arm of chromosome 8 is missing, but researchers had never been sure why this aneuploidy is so common.

DNA 122

DNA Medical Schools Treatment Research 122

Broad Institute

NOVEMBER 13, 2023

Liquid biopsies enable clinicians to find and analyze tumor DNA in a patient’s blood sample to detect cancer early, monitor cancer recurrence, assess the patient’s response to treatment, and measure other clinically important features in real time, without invasive procedures.

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DNA Medical Schools Treatment Therapies 116

Broad Institute

FEBRUARY 11, 2025

Its T cells in particular are famous for their ability to attack tumors, leading to immunotherapies that have revolutionized cancer treatment. Studies of cancer immunotherapy have largely focused on T cells, but the Bod lab seeks to understand whether the immune system's antibody-producing B cells can also be leveraged for cancer treatment.

Medical Schools 52

Medical Schools Immune Response Hospitals Doctors 52

Broad Institute

MAY 30, 2023

She realized the importance of her role in keeping the worms healthy, so she could later study their gene expression and behavior in response to different drug treatments. I told him I was struggling with my classes and that I didn’t think I'd make it to medical school. And if I did, I wouldn’t be happy.

Research 89

Research Medical Schools Doctors Science 89

Drug Target Review

NOVEMBER 8, 2023

Cell therapies hold immense promise for revolutionising the treatment of some of the most challenging diseases, but several technological and logistical hurdles stand in the way of unlocking their full potential. These patients typically fail frontline chemotherapies within 8 months of treatment and have few options for second line therapies.

Therapies 116

Therapies Engineering Treatment Molecular Biology 116

Drug Target Review

JULY 1, 2024

As a non-opioid, SRP-001 also eliminates abuse potential, positioning it as a safer and effective drug candidate for the treatment of acute and neuropathic pain and migraine headache. How does SRP-001’s safety profile, especially concerning hepatotoxicity and nephrotoxicity, compare to other common pain medications?

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Treatment Clinical Trials Therapies Molecular Biology 59

biobide

FEBRUARY 2, 2024

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. Zebrafish Pioneers Advance in Pediatric Cancer Research and Treatment Increasing the survival rate is the primary goal when screening for cancer drugs.

Disease 59

Disease Medical Schools Pharma Companies Clinical Trials 59

Broad Institute

JANUARY 25, 2024

“This could potentially help with disease prevention — if we know from someone’s retinal image that they are at high risk of developing glaucoma or cardiovascular disease in the future, we could refer them for follow-up screening or preventative treatment.”

Disease 124

Disease Research Science Medical Schools 124

Broad Institute

OCTOBER 23, 2024

His work leverages advanced screening platforms and engineered human stem cell models to drive innovations in heart failure treatment. Before joining PCL, Trembley served as an instructor and research fellow at Boston Children's Hospital and Harvard Medical School.

Medical Schools 52

Medical Schools Engineering Laboratories Doctors 52

Drug Target Review

JULY 13, 2023

Drug discovery is a complex and vital field that continually seeks to identify new therapeutic targets and develop effective treatments. He holds a PhD in Biology from The Rockefeller University and an MD from Weill Cornell Medical College. In 2022, Isaac was named one of Endpoints News 20 under 40 in Biopharma.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

Broad Institute

AUGUST 31, 2023

Finally, we have an animal model with human-genetic validity and robust neurobiological overlap with human patients that can help scientists learn how existing treatments work and potentially help identify new ones,” said first author Zohreh Farsi, a staff scientist in the Sheng lab. “We

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RNA Medical Schools Research Science 143

The Pharma Data

SEPTEMBER 7, 2021

The first patients have been enrolled in a phase 1 randomized placebo-controlled clinical trial to study a therapeutic vaccine for opioid use disorder developed by researchers at the University of Minnesota Medical School. The study plans to enroll up to 45 volunteers.

Clinical Trials 52

Clinical Trials Vaccine Trials Medical Schools 52

Broad Institute

OCTOBER 17, 2024

By Leah Eisenstadt October 17, 2024 Credit: Kevin Middleton, Broad Communications In the Bhattacharyya lab, researchers develop methods to quickly identify the most appropriate treatments for bacterial infections. The findings appear in the Journal of Clinical Microbiology (link).

RNA 69

RNA Hospitals Laboratories Medical Schools 69

Broad Institute

MARCH 8, 2024

Levine and Siddle say that these findings could improve the precision of diagnostics and treatments in areas with high numbers of NMFI cases. First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad.

Research 111

Research Disease Medical Schools RNA 111

Broad Institute

OCTOBER 23, 2024

They knew that discovering the genetic cause of her disorder would help them find other people like her, help get the condition formally recognized as a new disease, and help them better advocate for research into new treatments. It wasn’t until Emma that this possibility came on everyone’s radar,” said Carvill.

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DNA RNA Disease Hospitals 128

The Pharma Data

JUNE 2, 2023

With only one currently approved treatment option, I see HS patients with a tremendous need for alternatives that reduce the disabling physical symptoms of HS, improve the emotional burden and help partially avoid invasive surgery, if treating early,” said Professor Christos C.

Medical Schools 52

Medical Schools Treatment Disease Therapies 52

The Pharma Data

SEPTEMBER 18, 2020

Promising Phase 2 data has been released at the European Society for Medical Oncology (ESMO) Virtual Congress 2020 for Sanofi and Regeneron’s jointly-developed PD-1 inhibitor Libtayo (cemiplimab) in the treatment of locally advanced basal cell carcinoma (BCC) in patients for whom hedgehog inhibitor (HHI) therapy is not applicable.

Medical Schools 52

Medical Schools Trials Therapies Hospitals 52

Broad Institute

FEBRUARY 7, 2024

Study reveals links between blood vessel biology and heart disease risk By Tom Ulrich February 7, 2024 Breadcrumb Home Study reveals links between blood vessel biology and heart disease risk Genetic alterations in cells lining blood vessels contribute to coronary artery disease, with implications for diagnostic and treatment strategies By Brigham and (..)

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Disease Hospitals Medical Schools Therapies 105

Alta Sciences

MARCH 27, 2024

Eryn has a wealth of expertise in diverse therapeutic areas and, after her experiences with battling cancer, a commitment to advancing the pharmaceutical industry by merging conventional and alternative treatments into one model. Not really, although I contemplated medical school for a while.

Drug Development 52

Drug Development Medical Schools Pharma Companies Drugs 52

The Pharma Data

JANUARY 17, 2021

Ophthalmologists are physicians who have completed four years of medical school and four years of residency training. Treatments they help administer include patching therapy, prisms and convergence exercises. Danielle Natale, an optometrist at the Krieger Eye Institute in Baltimore, said in an institute news release.

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Medical Schools Doctors Treatment Disease 52

The Pharma Data

JANUARY 25, 2021

from Harvard Medical School in Boston, and colleagues developed evidence-based guidelines for the management of VWD and agreed on 12 recommendations. Connell, M.D., president and chief executive officer of the National Hemophilia Foundation, said in a statement. Guidelines: Diagnosis. Guidelines: Management. © 2021 HealthDay.

Disease 52

Disease Medical Schools Laboratories Therapies 52

The Pharma Data

NOVEMBER 10, 2020

from Harvard Medical School in Boston, and colleagues developed machine learning models to predict antibiotic susceptibility using electronic health record data and built a decision algorithm for recommending the narrowest possible antibiotic to which a specimen is susceptible for the treatment of uncomplicated UTI.

Medical Schools 52

Medical Schools Science Therapies Trials 52

Advarra

FEBRUARY 28, 2023

Rebecca Lee Crumpler Rebecca Lee Crumpler was one of the first African American women to graduate from medical school and to practice medicine. Crumpler’s focus on the care of women and children and her dedication to research led her to publish “A Book of Medical Discourses” in 1883. and abroad.

Medical Schools 52

Medical Schools Laboratories Clinical Research Treatment 52

On Medicine

APRIL 6, 2023

I have a background in Biomedical Engineering prior to medical school and a particular interest in global health and healthcare in resource-limited settings. I continued working in this field and I did my PhD thesis on anthracycline-induced cardiotoxicity during and after treatment for childhood cancer.

Medical Schools 52

Medical Schools Hospitals Treatment International 52

The Pharma Data

NOVEMBER 22, 2020

The mice who received the treatment had double the life expectancy as their counterparts, with a 30% higher survival rate. Peer stated that his team plans to develop a treatment for all cancers and that their technique could be ready for humans within the next two years.

DNA 52

DNA Medical Schools Treatment Science 52

Broad Institute

OCTOBER 4, 2023

“This is an unprecedented opportunity to evaluate how immune responses work,” said Robert Manguso , who is co-senior author on the study, an associate member at the Broad, and an assistant professor at the Massachusetts General Hospital Center for Cancer Research and Harvard Medical School.

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Small Molecule Clinical Trials Trials Engineering 128

Drug Target Review

JUNE 6, 2023

In this IO arena, we continue to search for additional treatments that can further benefit patients. Immune checkpoint inhibitors, a well-established class of IO treatments, are designed to improve the ability of T-cells to fight cancer by removing inhibitory or suppressive mechanisms that may dampen the anti-cancer functions of T cells.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

The Pharma Data

NOVEMBER 30, 2020

It’s a simple concept: After a health care provider explains various details on treatment plans, medications and how to manage the disease at home, they then ask the patient to repeat back the information. Hong is an assistant professor at the University of Florida College of Public Health and Health Professions.

Doctors 52

Doctors Medical Schools Hospitals Disease 52

Drug Target Review

FEBRUARY 26, 2024

Rather than solely identifying tumour-associated mutations which can be specifically targeted for effective treatment, we now need to consider how non-mutational events play into both the development of the primary tumour and the development of therapy resistance. Dr Alani received her M.D.

Therapies 59

Therapies Molecular Biology Regulations Medical Schools 59

The Pharma Data

JUNE 2, 2022

The partnership with ASH will not only deliver better tools to track a baby’s diagnosis, but also support greater knowledge on treatment and care, including through publications on research findings, professional education and dissemination to policy makers and other audiences. Winter, MD, of the Robert H.

Disease 52

Disease Medical Schools Treatment Therapies 52

Broad Institute

AUGUST 4, 2022

By Tracy Hampton August 4, 2022 Credit: National Institutes of Allergy and Infectious Diseases, National Institutes of Health Colorized scanning electron micrograph of a B cell lymphocyte from a human donor.

Bioinformatics 52

Bioinformatics Medical Schools Hospitals Treatment 52

Drug Target Review

FEBRUARY 29, 2024

Nevertheless, the potential to pioneer and move the needle for patients with few treatment options drives me to push through. During my training, I saw US medical school admissions reach parity. As a growing field, gene therapy also presents its challenges and I have made personal sacrifices along the way.

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Therapies Disease Clinical Trials Science 111

Broad Institute

JULY 20, 2023

Please register at broad.io/stanleysymposium

Medical Schools 52

Medical Schools Hospitals DNA Disease 52

Broad Institute

JULY 10, 2023

We've come so far in the last decade — from the time my little brother had cystic fibrosis to now, scientists have developed a treatment for the fundamental cause of the disease,” Martin said. Martin felt at home in his lab right away. “It It’s a fantastic time to be a human geneticist.”

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Disease Bioinformatics Medical Schools Research 98