Drug Target Review

JANUARY 15, 2024

Each T cell expresses a TCR specific for an HLA‑presented peptide signal, and when that signal is detected a T cell expressing the relevant TCR can launch a complex array of immune effector responses that can suppress or destroy tumours or virus-infected cells. References Robinson R, McMurran C, McCully M, Cole D.

Engineering 110

Engineering DNA Virus Immune Response 110

Broad Institute

DECEMBER 6, 2023

By Allessandra DiCorato December 6, 2023 Credit: Len Rubenstein (right photo) Ang Cui (left) and Nir Hacohen (right). The immune system can carry out many biological processes, from killing viruses to fighting cancer, thanks in large part to approximately 100 key cell-signaling proteins called cytokines, which instruct immune cells what to do.

Immune Response 138

Immune Response RNA Disease Medical Schools 138

The Pharma Data

MAY 15, 2023

CHMP Adopts Positive Opinion Recommending Hepcludex® (Bulevirtide) for Full Marketing Authorization for the Treatment of Hepatitis Delta Virus (HDV) Gilead Sciences, Inc.

Virus 40

Virus Marketing Treatment Science 40

PLOS: DNA Science

AUGUST 22, 2024

Crichton had an MD from Harvard Medical School, but he never practiced medicine. Michael_Crichton’s output includes The Andromeda Strain, Jurassic Park, Congo, Twister, The Lost World, Prey, Sphere, Westworld, and the TV series ER. He had the top book, film, and TV series within the same week – twice. BUT WAIT!!!

DNA 68

DNA Virus Organic Chemistry Science 68

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Drug Target Review

MAY 16, 2024

Dr Feitelson earned his PhD at UCLA Geffen Medical School. She is an Associate Professor of Research at Temple University, with over 25 years of research experience, and is an expert in stem cell cancers, Hepatitis B Virus, and the gut microbiome. She is also the Co-inventor of SFA’s therapeutic technology.

Disease 64

Disease Therapies Medical Schools Treatment 64

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A. Bluebird’s method “uses a virus to drop an entire gene encoding a new hemoglobin.

Therapies 52

Therapies Disease Medical Schools Virus 52

The Pharma Data

NOVEMBER 1, 2020

Trial facilitated with coll a boration of Harvard Medical School and one of the world’s top Neurologist, Dr. Howard Weiner. Highly innovative first-in-class study for treating COVID-19 disease with nasally administered drug. Clinical Data Expected by End of Year. NEW YORK and LONDON, Nov.

Clinical Trials 40

Clinical Trials Trials Medical Schools Hospitals 40

The Pharma Data

JANUARY 3, 2021

The clinical study was completed in collaboration with scientific teams at the Harvard Medical School (Boston, USA), Santa Casa de Misericórdia de Santos Hospital (Santos, Brazil) and INTRIALS, a world-class, full-service Latin American CRO based in São Paulo, Brazil. . NEW YORK and LONDON, Jan. Dr. Howard Weiner (the Robert L.

Clinical Trials 40

Clinical Trials Science Treatment Trials 40

The Pharma Data

JANUARY 24, 2021

The newly identified anti-COVID-19 Spike protein VNARs block infection of the virus (in live viral assays) at doses as low as 200 pM, equivalent to the best reported antibodies and much better than many. We then screened these for VNAR binders that block viral infection, and are delighted with the outcomes.”

Research 40

Research Virus Medical Schools Government 40

The Pharma Data

OCTOBER 15, 2020

The award honors McHutchison’s work in developing life-changing and curative therapies for patients with the hepatitis C virus. Prior to his corporate experience, he was an instructor at the Harvard Medical School in the Endocrine unit. BeyondSpring – BeyondSpring Inc.

Pharmaceuticals 52

Pharmaceuticals Clinical Pharmacology Medical Schools Therapies 52

Drug Target Review

DECEMBER 28, 2023

Sergio holds a PhD from Dartmouth Medical School and from 2004 to 2010 he held a post-doctoral position at Memorial Sloan-Kettering Cancer Center. Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Our immune system helps us to fight off infections and cancer.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Codon

JUNE 26, 2023

A phage is a virus that infects bacteria. But LLMs will greatly increase the number of people who could make or distribute a virus. Scientists from the Cincinnati Zoo and Harvard Medical School used AAV9 to deliver and express a gene encoding the AMH hormone in six cats. ” Bacteriophages infect a bacterium.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

A phage is a virus that infects bacteria. But LLMs will greatly increase the number of people who could make or distribute a virus. Scientists from the Cincinnati Zoo and Harvard Medical School used AAV9 to deliver and express a gene encoding the AMH hormone in six cats. ” Bacteriophages infect a bacterium.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Broad Institute

JANUARY 5, 2024

Using only information available pre-pandemic, EVEscape is as accurate as high-throughput experimental scans at anticipating pandemic variation for SARS-CoV-2 and is generalizable to other viruses.

Medical Schools 40

Medical Schools Vaccine Virus 40

Broad Institute

JANUARY 30, 2024

He has also emerged in recent years as a skilled and relatable science communicator, renowned for his efforts at Broad and beyond during the COVID-19 pandemic to unpack the fast-moving research on the new virus in an accessible way and give practical advice about masking, vaccines, and other public health measures.

Hospitals 137

Hospitals Virus Medical Schools Science 137

PLOS: DNA Science

JULY 27, 2023

The owners of the felines all reported feeding their pets raw meat, and samples of the meat revealed not only flu virus genetic material, but also infectious virus. The fear is that a variant of the deadly virus might emerge that infects people, and, worst-case-scenario, passes from person to person. emerged in late 2021.

Disease 92

Disease DNA Virus RNA 92

The Pharma Data

NOVEMBER 17, 2021

Now, new research led by investigators at Harvard Medical School and Boston Children’s Hospital points to a well-known and widely available drug called disulfiram as a possible treatment for COVID-19. If disulfiram’s effect against SARS-CoV-2 is confirmed, it could become a useful tool against the virus. A Pandemic Pivot.

Virus 52

Virus Drugs Clinical Trials Medical Schools 52

Codon

OCTOBER 6, 2024

However, in a recent study using sheep , a team at the University of Michigan Medical School found that a nitric-oxide-rich ECMO circuit allowed them to operate an artificial womb without blood thinners. Finally, transferring the baby to the artificial womb poses several challenges. Tom Ireland is an award-winning science journalist.

FDA 114

FDA Hospitals Engineering Research 114

The Pharma Data

DECEMBER 29, 2020

Instead, it may have been identified there first because the British government has a strong monitoring system that has tracked tens of thousands of genomic sequences of virus samples. The United States has lagged in sequencing and does not have nearly the same level of virus surveillance, the newspaper said. The sequencing in the U.S.

Clinical Trials 52

Clinical Trials Vaccine Trials Immune Response 52

Drug Target Review

FEBRUARY 15, 2024

Since the 20 th century, all known viral pandemics, including HIV, influenza, SARS CoV-1, SARS, CoV-1, and mpox, have resulted from a virus ‘spilling over’ from animals into humans. For example, scientists cannot accurately predict which town or village will have the next Nipah virus outbreak.

Drug Development 122

Drug Development Virus Vaccine Government 122

Broad Institute

NOVEMBER 6, 2024

This study is a game-changer, paving the way to unearthing the roots of these complications. We are incredibly grateful to each and every patient who partnered with us, all those involved in their clinical care, and the exceptional team in our lab who made this research possible.”

Immune Response 125

Immune Response Medical Schools Clinical Trials Treatment 125

The Pharma Data

DECEMBER 23, 2020

Instead, it may have been identified there first because the British government has a strong monitoring system that has tracked tens of thousands of genomic sequences of virus samples. The United States has lagged in sequencing and does not have nearly the same level of virus surveillance, the newspaper said. The sequencing in the U.S.

Vaccine 52

Vaccine Government Virus Medical Schools 52

The Pharma Data

DECEMBER 22, 2020

Instead, it may have been identified there first because the British government has a strong monitoring system that has tracked tens of thousands of genomic sequences of virus samples. The United States does not have nearly the same level of virus surveillance, the newspaper said. “It may very well be here.

Packaging 52

Packaging Vaccine Government Hospitals 52

The Pharma Data

DECEMBER 28, 2020

Instead, it may have been identified there first because the British government has a strong monitoring system that has tracked tens of thousands of genomic sequences of virus samples. The United States has lagged in sequencing and does not have nearly the same level of virus surveillance, the newspaper said. The sequencing in the U.S.

Vaccine 52

Vaccine Government Virus Medical Schools 52