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Metabolism of macrocyclic drugs

Metabolite Tales Blog

Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Journal of Medicinal Chemistry 62 (21), 9418-9437. Balazs et al.,

Drugs 52
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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Journal of Medicinal Chemistry 62 (21), 9418-9437. Balazs et al.,