Drug Target Review

MAY 22, 2024

There are siRNAs in clinical development for liver-associated AATD, but there are no approved therapeutics available and presently the only treatment option is liver transplantation. Dr Wiklund holds a PhD in Molecular Biology from Aarhus University, Denmark, and the Garvan Institute of Medical Research, Sydney, Australia.

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

APRIL 2, 2024

I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits. Slides from a lab talk presented in Heidelberg, Germany in 1998.

RNA 56

RNA Engineering Molecular Biology Synthetic Chemistry 56

Codon

JULY 27, 2023

“The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” It fills up an entire bookcase ! You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

“The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” It fills up an entire bookcase ! You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

FEBRUARY 13, 2024

coli in urinary tract infections, Garofolo says they achieved a 6-log reduction in bacterial numbers in patients (meaning the number of bacterial cells present has been reduced a million-fold), leading to “100 percent clinical cure” of all 31 patients. In a trial of their most advanced asset, a phage mixture targeting E.

Therapies 118

Therapies DNA Virus Clinical Trials 118

Codon

JUNE 26, 2023

(For context, the AAV9 that is often used in gene therapies has a packaging limit of 4,700 DNA bases.) The first presents a new method to count mRNAs and proteins, in individual plant cells, at the same time. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

(For context, the AAV9 that is often used in gene therapies has a packaging limit of 4,700 DNA bases.) The first presents a new method to count mRNAs and proteins, in individual plant cells, at the same time. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history.

DNA 52

DNA Therapies Engineering Clinical Trials 52