Broad Institute

AUGUST 16, 2023

They studied the copy number of mitochondrial DNA, mutations present within the mitochondrial DNA itself, and the places in the nuclear genome influencing these traits. The work is the first of its kind of this size to study both nuclear and mitochondrial DNA from humans of diverse ancestries to date.

DNA 98

DNA Molecular Biology Disease Regulations 98

DrugBaron

NOVEMBER 22, 2022

Most proteomics methodology used today provides an enumeration of the major proteins present with poorly validated attempts at quantitation and even less focus on the subtly different variants of each “protein” present in the mixture.

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Codon

APRIL 2, 2024

I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits. Slides from a lab talk presented in Heidelberg, Germany in 1998.

RNA 56

RNA Engineering Molecular Biology Synthetic Chemistry 56

BMG Labtech

MARCH 8, 2023

In fact, metabolism should not be considered as a self-regulating entity that is independent of other biological pathways. For instance, intermediates of the TCA cycle are present in all known organisms from unicellular bacteria to complex and large multicellular organisms like elephants. 7 (3): 276–82. doi:10.1038/sj.embor.7400646.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

FEBRUARY 13, 2024

Regulators traditionally want to see a single, stable, well-characterized drug before giving the green light for it to be tested in a clinical trial, not dozens of different viruses; let alone ones that are best found in unappealing places like sewage , hospital waste, or bird poop.

Therapies 118

Therapies DNA Virus Clinical Trials 118

Codon

JUNE 25, 2024

Sometimes cells don’t take up the DNA, or unforeseen issues with the modified sequence arise—such as off-target mutations, unexpected protein modifications, or disruptions to gene regulation—that send us back to the drawing board. These setbacks can extend the timeline from days to weeks. The resulting strain of V.

DNA 70

DNA RNA Laboratories Engineering 70

Codon

JULY 27, 2023

“The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” It fills up an entire bookcase ! You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

“The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” It fills up an entire bookcase ! You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Journal of Molecular Biology (1961). Gene Expression and Regulation. Nature Reviews Molecular Cell Biology (2008). Link The Systems Biology Graphical Notation , by Le Novère N.

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Journal of Molecular Biology (1961). Gene Expression and Regulation. Nature Reviews Molecular Cell Biology (2008). Link The Systems Biology Graphical Notation , by Le Novère N.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

JUNE 26, 2023

The first presents a new method to count mRNAs and proteins, in individual plant cells, at the same time. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. plasmidsaurus @arjunrajlab (Regulation in biology is incredible. Paper by Sha G.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

The first presents a new method to count mRNAs and proteins, in individual plant cells, at the same time. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. plasmidsaurus @arjunrajlab (Regulation in biology is incredible. Paper by Sha G.

DNA 52

DNA Therapies Engineering Clinical Trials 52

The Pharma Data

DECEMBER 2, 2020

After discussing the application and any concerns, the FDA presents questions and the committee votes on each question. Regulators must “move as quickly as possible, but not so quickly as to erode confidence,” she continued. Although the Agency has a staff of about 17,000, “It can’t have experts for every single disease,” Durbin said.

Vaccine 52

Vaccine FDA Molecular Biology Licensing 52