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Logistics in Focus: Orchestrating the Challenges of Cell Therapy

Conversations in Drug Development Trends

These advanced therapeutics harness the power of molecular biology to improve human health. The process, from patient coordination through manufacturing and administration, is intricate, time-sensitive, and highly regulated. Operationalizing these trials requires proactive and flawless management at every stage.

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A quiet revolution in the world of proteomics

DrugBaron

Most proteomics methodology used today provides an enumeration of the major proteins present with poorly validated attempts at quantitation and even less focus on the subtly different variants of each “protein” present in the mixture.

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Nuclear DNA influences variation in mitochondrial DNA

Broad Institute

They studied the copy number of mitochondrial DNA, mutations present within the mitochondrial DNA itself, and the places in the nuclear genome influencing these traits. The work is the first of its kind of this size to study both nuclear and mitochondrial DNA from humans of diverse ancestries to date.

DNA 98
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My Attendance at the 2024 Boston Society Cell and Gene Therapy Conference

Alta Sciences

Attendees were encouraged to engage in several talks and presentations throughout the day, and the event organizers had done a fantastic job assembling an outstanding lineup of speakers/key industry leaders to spark extensive discussions. Of all the high-quality presentations I attended, two in particular caught my attention.

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Gamma delta T cells: a rising star in cancer therapy

Drug Target Review

2,3 However, unlike αβ T cells, which are activated by the presentation of antigens to their TCRs, γδ T cells do not require antigen presentation to become activated. Regulation of cutaneous malignancy by gammadelta T cells. and MBA students with real-world consulting experiences. References Fichtner A, Ravens S, Prinz I.

Therapies 105
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Mediating BRAF-mutant melanoma resistance

Drug Target Review

Our data demonstrate that the CoREST complex is a critical mediator of the distinct melanoma phenotypes, working through the regulation of both the phenotype-defining genes MITF and AXL as well as the master regulators of epithelial-to-mesenchymal transitions (EMT) and phenotype switching in melanoma and other cancers, SNAIL/SLUG/ZEB1/ZEB2.

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Trends & Insights: Spotlight Winter Edition

DrugBank

1 Present address: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. 2 Cancer Program, Broad Institute of MIT and Harvard, USA.