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Battling antibiotic resistance in the lab and the clinic

Broad Institute

His advisor marched him down to the office of a new faculty member, Tobin Sosnick, who is now chair of the Department of Biochemistry and Molecular Biology at the University of Chicago. Sosnick was still unpacking boxes, yet he stopped what he was doing, sat Bhattacharyya down, and described his work to learn how proteins fold.

Hospitals 137
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Enhancing gene therapy with Circio

Drug Target Review

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

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A target for potential cancer drugs may, in fact, worsen disease

The Pharma Data

By creating genetically finagled mouse models and doing single cell RNA-sequencing, Feng and associates plant that Shp2 was needed by excrescence cells for HCC development, which validated and corroborated allowing that Shp2 presented an ideal target for new cancer curatives. ” Source link: [link].

Disease 52
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Leveraging ADCs in precision oncology strategy

Drug Target Review

By identifying proteins that only interact with each other in cancer, but not normal tissues, we can really expand the repertoire of ADC therapeutics beyond monoclonal antibodies developed based solely on RNA expression profiles. His work has been published in many high-impact journals and presented at international oncology meetings.

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Breaking the Speed Limit on Cell Division

Codon

Proteins are colored blue and RNA molecules are colored orange and yellow. RNA and proteins comprise each ribosome, but the cell synthesizes these two biomolecules at different rates. Recall that a typical ribosome in bacteria is built from 50 proteins and 3 strands of RNA. The large and small ribosome subunits.

DNA 82
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Synthetic Origins

Codon

I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits. Slides from a lab talk presented in Heidelberg, Germany in 1998.

RNA 57
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SRP-001: redefining pain treatment with a safer, non-opioid analgesic

Drug Target Review

Can you discuss the single-cell transcriptomic analysis presented in the paper and its implications for understanding the pain-relief mechanisms of SRP-001? The single-cell transcriptomic analysis in the Sci Reports paper 1 provides insights into SRP-001’s pain-relief mechanisms.