Drug Target Review

OCTOBER 13, 2023

For each of these ten diverse growth conditions, they cultivated 25 cultures and subsequently subjected the various samples to molecular biology techniques (referred to as multi-omics) that enable simultaneous analysis of all transcribed genes, all produced proteins, and all metabolic products within a cell.

Molecular Biology 105

Molecular Biology Doctors Research Production 105

sptlabtech

JUNE 9, 2023

Using our innovative true positive displacement technology, firefly is fully compatible with all molecular biology reagents, viscous and volatile, as well as bead suspension, making it an ideal solution for genomics workflows. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Laboratories 98

Laboratories Molecular Biology DNA Engineering 98

Drug Target Review

NOVEMBER 27, 2023

In cancer, the eIF4F complex becomes dysregulated, leading to the excessive production of these proteins, which contribute to tumour formation and resistance to treatment. STRIs disrupt the production of multiple pathway-related proteins at the same time, making it more difficult for cancer cells to develop resistance.

Molecular Biology 86

Molecular Biology Therapies Pharmaceuticals Treatment 86

Drug Target Review

NOVEMBER 8, 2023

Currently, only a small percentage of cancers can be effectively treated with cell therapies, and there is little diversity in the currently approved products. Moreover, solid tumours pose a unique challenge, as they create an immunosuppressive tumor microenvironment, making it difficult for cell therapies to be effective.

Therapies 116

Therapies Engineering Treatment Molecular Biology 116

FDA Law Blog: Drug Discovery

MAY 1, 2024

Sarah brings a wealth of experience and a proven track record of advising innovative drug and biologics companies through the intricate landscape of product development and commercialization. Sarah graduated with a cum laude degree in Cell and Molecular Biology from Towson University, a M.P.H. Hyman, Phelps & McNamara, P.C.

Drug Development 52

Drug Development Molecular Biology Compliance Clinical Trials 52

sptlabtech

JUNE 9, 2023

Using our innovative true positive displacement technology, firefly is fully compatible with all molecular biology reagents, viscous and volatile, as well as bead suspension, making it an ideal solution for genomics workflows. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Molecular Biology 52

Molecular Biology DNA Laboratories Disease 52

The Pharma Data

JANUARY 19, 2021

A range of companies are exploring potential gene editing therapies based on a CRISPR-Cas9 system, and the ability to tune the CRISPR cut could prevent off-target editing or control the degree of a target protein’s production.

Research 52

Research RNA Molecular Biology Small Molecule 52

The Pharma Data

JANUARY 26, 2021

Concomitant research in biomaterials, biomechanics, electrophysiology, and molecular biology has expanded the horizon of the orthopedics market. Tonsil and Adenoid Removal Products Market: [link]. Orthopedics emerged as a new specialty around the world over the past five decades. Request Brochure of Report – [link].

Marketing 52

Marketing Disease Molecular Biology Research 52

Drug Target Review

OCTOBER 3, 2024

8 These libraries enable the generation of antibodies enhancing biotherapeutic analysis during preclinical and clinical development and routine drug monitoring, while also addressing common antibody production challenges. Methods in Molecular Biology. Journal of Molecular Biology. References Köhler G, Milstein C.

Molecular Biology 52

Molecular Biology Pharmacokinetics Laboratories Animal Testing 52

Drug Target Review

DECEMBER 7, 2023

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. This parallels how the analogous system operates in humans.

RNA 59

RNA Immune Response DNA Molecular Biology 59

The Pharma Data

NOVEMBER 22, 2021

The Centre will help farther nurture hookups, develop the coming generation of wisdom leaders and accelerate AstraZeneca’s assiduity- leading situations of productivity. The life lores cluster in Cambridge The life lores cluster in Cambridge is the most productive in Europe. region in the US, and Gothenburg in Sweden.

Molecular Biology 52

Molecular Biology Laboratories Engineering Hospitals 52

DrugBank

FEBRUARY 9, 2023

1 Present address: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. 2 Cancer Program, Broad Institute of MIT and Harvard, USA. 3 Research Focus: Network-based drug repositioning strategy to identify drugs targeting obesity and type 2 diabetes.

Clinical Pharmacology 52

Clinical Pharmacology Molecular Biology DNA Licensing 52

Drug Target Review

AUGUST 29, 2024

We think that, over the traditional CAR product, a product that uses gene editing, using CRISPR gene knockout of CD5, would potentially lead to stronger anti-tumour effects in multiple cancer models. How is Vittoria Biotherapeutics leveraging the findings about CD5 to develop their lead program, VIPER-101, for T-cell lymphoma?

Therapies 59

Therapies Treatment Engineering Molecular Biology 59

The Pharma Data

JANUARY 6, 2021

CytoDel” or “the Company”), a privately-held corporation, today announces the publication of preclinical data on the Company’s lead product, Cyto-111, in the peer-reviewed journal, Science Translational Medicine. All currently available treatments for botulism are antibody products which can only neutralize toxin in the systemic circulation.

Science 52

Science Molecular Biology Treatment FDA Approval 52

Drug Target Review

JUNE 11, 2024

When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. The product we are developing at OMINI is unique.

Engineering 64

Engineering Science Molecular Biology Doctors 64

Broad Institute

OCTOBER 16, 2024

William Studier for development of widely used protein- and RNA-production platform F. Merkin (left) and F. William Studier (right). Related news and video Merkin Prize in Biomedical Technology awarded to F. William Studier receives the 2024 Merkin Prize (video) The 2024 Richard N. Merkin Prize in Biomedical Technology was awarded to F.

Vaccine 64

Vaccine RNA Laboratories Molecular Biology 64

Drug Target Review

JUNE 19, 2024

We look at that long list and ask which of the cell types looks attractive to us as a potential product. He received a BS in biology from Boston College, a masters in biochemistry and molecular biology from the University of California, Santa Barbara, and an M.B.A.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

The Pharma Data

JANUARY 18, 2021

Yesse Technologies’ core technology, the ORion21 genetic platform, is the product of over 30 years of fundamental research on the molecular biology of the sense of smell and is exclusively licensed from The City University of New York.

Disease 40

Disease Molecular Biology Licensing Licensing 40

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. This heterodimer will bring more meaning to your work, enhance your productivity, and open doors over time. Remember life’s Central Dogma. Don’t differentiate too quickly.

Science 86

Science Immune Response Molecular Biology RNA 86

The Pharma Data

NOVEMBER 19, 2020

The program is being led by Sosei Heptares and progressed in collaboration with multiple companies including Syngene International, Domainex, Fidelta, o2h Discovery, Piramal, WuXi AppTec and the MRC Laboratory of Molecular Biology. Forward-looking statements.

Small Molecule 40

Small Molecule Structure Based Drug Design (SBDD) International Molecular Biology 40

The Pharma Data

JANUARY 4, 2021

Longwood has a robust research department with 7 post doctorates conducting research in molecular biology, microbiology, genomics, cancer biology, and immunology and publishing over 75 publications in different scientific journals in the past 5 years. Barber also serves on Kiromic’s Scientific Advisory Board.

Therapies 40

Therapies Molecular Biology Immune Response Science 40

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. 49 years ago, when I was 16 years old, I wanted to do exactly what I am doing now.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

The Pharma Data

JANUARY 25, 2021

“The technology has a unique pharmacological profile, which is very different from other products in preclinical and clinical development in that it focuses on restoring function. .” “I am excited about the potential of NVG-291,” stated Dr. Perry.

Disease 40

Disease Clinical Development Molecular Biology Treatment 40

Drug Target Review

MARCH 15, 2024

Advancements in cell line development (CLD), including screening and selection of final clones, scale up, automation and digitalisation have enabled precision and enhanced productivity. Subsequently, stable clones are screened, identified and characterized, leading to clonal cell banks for GMP production of the drug product.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105

DrugBaron

NOVEMBER 22, 2022

For example, it is well known that glycation of haemoglobin through non-enzymatic reaction with glucose to generate a product known as Hba1c is a useful measure of glycemic control in diabetic subjects. This can be useful to quantify protein adducts (for example when radiolabelling a protein or preparing antigens for vaccine production).

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Broad Institute

AUGUST 7, 2023

When STING detects that danger signal, it can turn on at least three different pathways — one leading to interferon production, one to non-canonical autophagy (involved in recycling cell components and clearing pathogens), and a third to formation of the inflammasome, a complex of proteins that activates inflammatory responses.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Codon

FEBRUARY 13, 2024

By 2004, over a dozen companies were working on developing phage products and therapies, in locations ranging from Baltimore to Bangalore, where ten years previously, there had been none. Phage-based products have been licensed for use as antibacterial agents in the sanitation , food production , and animal health industries.

Therapies 131

Therapies Virus DNA Clinical Trials 131

The Pharma Data

MARCH 16, 2022

As Professor Patrick Cramer, Professor at the Max-Planck Institute for Multidisciplinary Sciences and Director of the Molecular Biology Department, emphasized in his congratulatory speech: “Kai Johnsson is a world-leading research scientist in chemical biology.

Cell Biology 52

Cell Biology Molecular Biology Science Research 52

Codon

JUNE 25, 2024

During my doctoral training, I split my work between wet lab research and programming, two streams that differed radically in terms of productivity. In contrast, coding errors, while expected, disrupt productivity far less—so much so that programmers joke that “code never works the first time around.”

DNA 82

DNA RNA Laboratories Research 82

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. There’s not a single molecular biology or biochemistry lab I know that doesn’t use T7.” Merkin Prize in Biomedical Technology awarded to F.

RNA 84

RNA Production Molecular Biology Laboratories 84

BMG Labtech

MARCH 8, 2023

This coordinated series of biochemical reactions where the product of one conversion becomes the substrate for another reaction is known as metabolic pathways. Metabolism also includes the disposal of waste and by-products. Anabolism consists of three basic steps: the production of precursor molecules (e.g.,

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Broad Institute

JUNE 21, 2023

said Vamsi Mootha , senior author of the study, an institute member at the Broad, professor of systems biology and medicine at Harvard Medical School, and professor of molecular biology at Massachusetts General Hospital.

Treatment 98

Treatment Disease Molecular Biology Medical Schools 98

Drug Target Review

MAY 22, 2024

We have built a circVec remove-&-replace construct for AATD where we are able to solve both of these issues in one product, expressing the functional wild-type AAT protein from circRNA and removing the mutant form in a sequence-specific and exonucleolytic manner.

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

APRIL 2, 2024

I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits. So over time, waste products pile up in the media, and the cells grow more slowly.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

The Pharma Data

SEPTEMBER 17, 2020

Roche is working closely with governments and health authorities around the world, and has significantly increased production to help ensure availability of tests globally. The molecular biology of coronaviruses. The Lancet 396:479 – 4882) [2] Masters PS (2006). Advances in Virus Research. Academic Press. 81(2):271-280.e8;

Vaccine 52

Vaccine Virus Clinical Trials Immune Response 52

Agency IQ

JANUARY 19, 2024

Revised ICH viral safety guideline: NGS is in, animal use (mostly) out The EMA and FDA are implementing revisions to an important quality guideline, addressing viral safety for products derived from human or animal cell lines (ICH Q5A R(2)). To prepare cells for use in product manufacture or to be banked—i.e.,

Virus 40

Virus Science Production FDA 40

Vial

MARCH 1, 2024

billion in 2023 attributable to its laboratory products and biopharma services segment (53.8% Recent and significant activities among these top CROs based in the US include the acquisition of Pharmaceutical Product Development (PPD), a global industry leader in clinical development and analytical services, by Thermo Fisher Scientific Inc.

Clinical Trials 52

Clinical Trials Clinical Research Trials Laboratories 52