Drug Discovery World
NOVEMBER 27, 2023
For instance, the engineering of CHO cells, widely used protein expression system, for various metabolic pathways has resulted in improved expression levels of large molecule drugs and product quality 1,2. After engineering, stable clones are screened, identified, and characterised. Biotechnol Bioeng 2012;118:2326.
Drug Target Review
MARCH 15, 2024
As discussed above, recent advances in gene editing tools and transposon-based vectors have facilitated targeted and consistent cell line engineering for the development of protein expressing CHO cell lines. Anis also serves on the scientific and editorial advisory board of Genetic Engineering News at Mary Ann Liebert, Inc.
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Drug Discovery World
APRIL 30, 2024
This is essential to its use as a therapeutic agent and gives the technology a vast versatility making it suitable to treating a wide range of diseases – especially those that have high protein expression. mRNA-based approaches can produce proteins / peptides by using protein synthesis which is processed in a transfected cell 1.
Drug Discovery World
NOVEMBER 9, 2023
Novel approaches This session will feature two luncheon presentations: Nicholas Field, Principal Scientist, Purification Development, Lonza, on: ‘Tailored CMC solutions to overcome the challenges in bispecific, Fab and Fc-fusion protein development programs’.
The Pharma Data
JANUARY 13, 2021
based Mogrify Limited expanded its research collaboration with MRC Laboratory of Molecular Biology. The project aims to develop novel protein expression systems by leveraging recent advances in direct cell reprogramming to help improve the production of proteins which are not produced sufficiently well in existing expression systems.
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