Codon

JULY 17, 2024

I want to see amateur biology thrive, and while a lot of regulations exist for a reason, I’m unconvinced that molecular biology requires all the crazy expensive equipment that has become associated with it. I mean, how did people do molecular biology fifty or one hundred years ago?

Laboratories 92

Laboratories Engineering Molecular Biology Science 92

The Pharma Data

NOVEMBER 23, 2020

Zhang’s arrest was for “the suspected offense of smuggling goods prohibited by the import and export regulations under the laws of the PRC,” according to a GenScript statement. Human genetic goods are tightly regulated by the Chinese government. as a director of molecular biology.

Government 52

Government Molecular Biology Regulations Laboratories 52

DrugBaron

NOVEMBER 22, 2022

But data is accumulating to suggest it matters a lot: resolving one variant from another – and understanding what drives their relative concentrations – may be just as important in biology as regulation of gene expression.

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Alta Sciences

JUNE 11, 2024

One thing is for sure—regardless of how the field evolves around regulation requirements, Altasciences has the experience and range of capabilities to take on your gene therapy drug development programs. Final Thoughts It goes without saying (but I’ll say it anyway): Cell and gene therapy is a field in rapid evolution. About the Author Dr.

Therapies 52

Therapies Molecular Biology Immune Response Science 52

Drug Target Review

FEBRUARY 26, 2024

Our data demonstrate that the CoREST complex is a critical mediator of the distinct melanoma phenotypes, working through the regulation of both the phenotype-defining genes MITF and AXL as well as the master regulators of epithelial-to-mesenchymal transitions (EMT) and phenotype switching in melanoma and other cancers, SNAIL/SLUG/ZEB1/ZEB2.

Therapies 59

Therapies Molecular Biology Regulations Medical Schools 59

Drug Target Review

OCTOBER 3, 2024

3 This change signals a major shift away from animal use in drug safety regulation and encourages the use of alternative methods like organ-on-chip or other animal-free technologies. Methods in Molecular Biology. Journal of Molecular Biology. 2021;291–306. Prassler J, Thiel S, Pracht C, et al.

Molecular Biology 52

Molecular Biology Pharmacokinetics Laboratories Animal Testing 52

DrugBank

FEBRUARY 9, 2023

1 Present address: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. Summary: This paper discusses the use of a data science approach to synthesize current knowledge on the pharmacological implications of epigenetic regulation of gene expression.

Clinical Pharmacology 52

Clinical Pharmacology Molecular Biology DNA Licensing 52

Drug Target Review

FEBRUARY 28, 2024

Dr Rochlin earned a PhD in Molecular Biology and Genetics from Weill Cornell Medical College, conducting research at Sloan Kettering Institute, and a BA in Biology from the University of Pennsylvania. Regulation of cutaneous malignancy by gammadelta T cells. and MBA students with real-world consulting experiences.

Therapies 105

Therapies Engineering Molecular Biology Science 105

Drug Target Review

JULY 1, 2024

SRP-001 targets the central nervous system (CNS) by producing N-arachidonoylaminophenol (AM404) in the midbrain’s periaqueductal grey (PAG) region, crucial for pain sensation and regulation. He and his team have completed Phase I clinical trials, paving the way for Phase II RCTs in acute and neuropathic pain.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Codon

FEBRUARY 13, 2024

Regulators traditionally want to see a single, stable, well-characterized drug before giving the green light for it to be tested in a clinical trial, not dozens of different viruses; let alone ones that are best found in unappealing places like sewage , hospital waste, or bird poop.

Therapies 124

Therapies Virus DNA Clinical Trials 124

Broad Institute

NOVEMBER 17, 2023

Her research seeks to understand the mechanisms that regulate the disappearance of synapses — junctions where nerves communicate with each other — by focusing on how immune-related molecules mediate this process.

Organic Chemistry 52

Organic Chemistry Engineering Molecular Biology Disease 52

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. I did a postdoc with Paul Berg at Stanford, studying transcriptional regulation. Arrakis is the capstone of my career.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Drug Target Review

OCTOBER 25, 2024

Progress in molecular biology and translational science. Α-synuclein in the pathophysiology of alzheimer’s disease – molecular neurodegeneration. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in alzheimer’s disease – acta neuropathologica.

Disease 59

Disease Clinical Trials Therapies Science 59

Alta Sciences

AUGUST 21, 2024

Throughout the summer, I learned the documentation, regulations, and accountability required to perform R&D work in an industrial laboratory. I was greatly inspired by the way Altasciences ensures all processes are rigorously regulated and traceable, as well as the way their integrated services provide clients with a seamless experience.

International 40

International Laboratories Science Molecular Biology 40

BMG Labtech

MARCH 8, 2023

In fact, metabolism should not be considered as a self-regulating entity that is independent of other biological pathways. Alberts B, How Cells Obtain Energy from Food, Molecular Biology of the Cell (4th ed.). Alberts B, 2002, Energy Conversion: Mitochondria and Chloroplasts, Molecular Biology of the Cell (4th ed.).

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

The Pharma Data

JANUARY 4, 2021

Longwood has a robust research department with 7 post doctorates conducting research in molecular biology, microbiology, genomics, cancer biology, and immunology and publishing over 75 publications in different scientific journals in the past 5 years. Barber also serves on Kiromic’s Scientific Advisory Board.

Therapies 40

Therapies Molecular Biology Immune Response Science 40

Codon

APRIL 2, 2024

I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits. So many kinds of people have contributed to biology in different ways.

RNA 56

RNA Engineering Molecular Biology Synthetic Chemistry 56

The Pharma Data

JANUARY 25, 2021

With a background in molecular biology and clinical chemistry, Dr. Zetterberg has spent the last 20 years focusing on the development of biomarkers for Alzheimer’s disease, Parkinson’s disease and other brain disorders. Corey Davis Ph.D., LifeSci Advisors LLC cdavis@lifesciadvisors.com.

Disease 40

Disease Clinical Development Molecular Biology Treatment 40

Codon

JUNE 25, 2024

Sometimes cells don’t take up the DNA, or unforeseen issues with the modified sequence arise—such as off-target mutations, unexpected protein modifications, or disruptions to gene regulation—that send us back to the drawing board. These setbacks can extend the timeline from days to weeks. The resulting strain of V.

DNA 75

DNA RNA Laboratories Research 75

Codon

JUNE 18, 2024

Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. For more than a century, scientists thought of gas vesicles as little more than a natural curiosity and, later, as a way for microbes to regulate buoyancy.

Engineering 67

Engineering Laboratories International Clinical Trials 67

Agency IQ

JANUARY 19, 2024

The History of the ICH Q5A(R1) Guideline The International Council on Harmonization (ICH) Q5A(R1) Guideline, Viral Safety Evaluation of Biotechnology Products Derived from Cell Lines of Human or Animal Origin , was first adopted by regulators in 1999. This bulk product contains both the final product (e.g., also received some additions.

Virus 40

Virus Science Production FDA 40

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. You can read all of them here. And it’s true, but only in an incomplete way.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. You can read all of them here. And it’s true, but only in an incomplete way.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JUNE 26, 2023

Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. … There was a time when the film was being shown in biology courses from middle school to graduate courses in genetics and biochemistry and even in post graduate education lectures to physicians.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. … There was a time when the film was being shown in biology courses from middle school to graduate courses in genetics and biochemistry and even in post graduate education lectures to physicians.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Broad Institute

NOVEMBER 20, 2024

Scientists find a region of the mouse gut tightly regulated by the immune system By Allessandra DiCorato November 20, 2024 Breadcrumb Home Scientists find a region of the mouse gut tightly regulated by the immune system A spatial map of gene expression across the intestine reveals the organ’s remarkable adaptability.

Regulations 84

Regulations Immune Response Molecular Biology Disease 84

The Pharma Data

OCTOBER 18, 2020

NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. 19, 2020 10:32 UTC. LOS ANGELES–( BUSINESS WIRE )– ChromaDex Corp.

DNA 52

DNA Molecular Biology Disease Trials 52

Drug Target Review

FEBRUARY 19, 2025

“Contrary to popular opinion, regulation is not a hurdle, but rather an enabler. If the data package (including safety) is well thought out and developed from the beginning, regulations can be a support to frame the development journey.

Therapies 59

Therapies Molecular Biology Regulations Packaging 59

Drug Target Review

DECEMBER 12, 2024

Any study of the genome is incomplete without considering the epigenomic framework within which genes are read and regulated. Progress in molecular biology and translational science [Internet]. The fields of genomics and epigenetics are so closely linked that a breakthrough in one will often catalyse progress in the other.

Therapies 59

Therapies DNA Molecular Biology Immune Response 59

BMG Labtech

FEBRUARY 24, 2025

Protein nitration is one example that takes place on tyrosine residues which can have important consequences for the regulation of biological processes. Protein nitration assays are widely used in many research areas including but not limited to biochemistry , biotechnology , cell biology , microbiology , and molecular biology.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

Codon

JANUARY 8, 2025

Dave Schneider ) Sleep Biology In the Epic of Gilgamesh , the eponymous protagonist was challenged by the Mesopotamian king Utnapishtim to stay awake for 6 days and 7 nights in order to achieve immortality. In ideal circumstances, our circadian rhythms work well and regulate our hormonal cycles and mood. He was unable to do so.

Science 60

Science Vaccine Engineering Disease 60

The Pharma Data

DECEMBER 2, 2020

Regulators must “move as quickly as possible, but not so quickly as to erode confidence,” she continued. Although the Agency has a staff of about 17,000, “It can’t have experts for every single disease,” Durbin said. So, to expand its expertise, it relies on external experts on specialty committees.

Vaccine 52

Vaccine FDA Molecular Biology Licensing 52

Codon

DECEMBER 1, 2024

By Matthew Cobb The Central Dogma is a linchpin for understanding how cells work, and yet it is one of the most widely misunderstood concepts in molecular biology. That is pretty much exactly what happens in many microbes; gene regulation responds to environmental stimuli.

RNA 124

RNA DNA Molecular Biology Virus 124

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Journal of Molecular Biology (1961). Gene Expression and Regulation. Nature Reviews Molecular Cell Biology (2008). Link Molecular Cloning Techniques , by AddGene. & Xie X.S.

DNA 95

DNA Cell Biology Molecular Biology Engineering 95

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Journal of Molecular Biology (1961). Gene Expression and Regulation. Nature Reviews Molecular Cell Biology (2008). Link Molecular Cloning Techniques , by AddGene. & Xie X.S.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

NOVEMBER 1, 2024

I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. But looking ahead to the second bottleneck, what does it mean to say that biology is “complex”? It involves pragmatism and cultural sensitivity.

DNA 114

DNA RNA Molecular Biology Laboratories 114