The Pharma Data

JANUARY 19, 2021

A naturally occurring system for tuning CRISPR-Cas9 expressing in bacteria, identified in a study published in Cell , could have implications for gene editing therapies as well. The authors suggest natural tracr-L regulates autoimmunity. And removing tracr-L altogether greatly increased CRISPR-Cas9 expression.

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Drug Target Review

FEBRUARY 26, 2024

Regarding therapy resistant melanomas, why is the alteration of the epigenetic landscape considered significant, and what has been lacking in terms of validated targetable epigenetic mechanisms? What is remarkable here is that we show that the addition of corin to BRAFi-resistant tumour cells resensitises them to BRAFi therapies.

Therapies 59

Therapies Molecular Biology Regulations Medical Schools 59

The Pharma Data

NOVEMBER 23, 2020

Zhang’s arrest was for “the suspected offense of smuggling goods prohibited by the import and export regulations under the laws of the PRC,” according to a GenScript statement. Human genetic goods are tightly regulated by the Chinese government. Cilta-cel snagged Breakthrough Therapy Designation from the U.S.

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Government Molecular Biology Regulations Laboratories 52

Codon

JULY 27, 2023

But what happens if you restore these cone cells, using gene therapy? ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics.

Therapies 52

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Codon

JULY 27, 2023

But what happens if you restore these cone cells, using gene therapy? ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics.

Therapies 52

Therapies RNA DNA Engineering 52

Drug Target Review

JULY 1, 2024

SRP-001 targets the central nervous system (CNS) by producing N-arachidonoylaminophenol (AM404) in the midbrain’s periaqueductal grey (PAG) region, crucial for pain sensation and regulation. Could you elaborate on the potential market size for SRP-001 and how it fits into the broader landscape of pain therapies?

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Treatment Clinical Trials Therapies Molecular Biology 59

Drug Target Review

OCTOBER 25, 2024

Biomarkers are an essential advancement that will help determine risk for developing Alzheimer’s disease, diagnose the disease before symptoms have progressed significantly, predict how quickly patients may experience cognitive decline and evaluate how well new therapies are working. Progress in molecular biology and translational science.

Disease 59

Disease Clinical Trials Therapies Science 59

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. I did a postdoc with Paul Berg at Stanford, studying transcriptional regulation. Arrakis is the capstone of my career.

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The Pharma Data

JANUARY 4, 2021

. chPD1 will be used in the Company’s proprietary chimeric antigen receptor therapy (CAR-T) platform using gamma-delta T-cells (GD-T). Barber’s work will give Kiromic a significant acceleration in the clinical development of its therapy platform and an even more significant advantage over its competitors.

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Therapies Molecular Biology Immune Response Science 40

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. Nevertheless, phage therapy did have a stint in the U.S. I’ll post an update soon. coli in mice.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. Nevertheless, phage therapy did have a stint in the U.S. I’ll post an update soon. coli in mice.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 18, 2024

Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. For more than a century, scientists thought of gas vesicles as little more than a natural curiosity and, later, as a way for microbes to regulate buoyancy.

Engineering 67

Engineering Laboratories International Clinical Trials 67

Agency IQ

JANUARY 19, 2024

The History of the ICH Q5A(R1) Guideline The International Council on Harmonization (ICH) Q5A(R1) Guideline, Viral Safety Evaluation of Biotechnology Products Derived from Cell Lines of Human or Animal Origin , was first adopted by regulators in 1999. cell line type ) and the final product type. The Specific Precautions section (6.2.7)

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Virus Science Production FDA 40

Drug Target Review

FEBRUARY 19, 2025

Their capacity to provide an unlimited supply of cells means that iPSCs could revolutionise cell therapies. Together, they shared valuable insights into the progress of iPSC-based therapies, the key obstacles ahead and the exciting opportunities for future breakthroughs.

Therapies 59

Therapies Molecular Biology Regulations Packaging 59

Drug Target Review

DECEMBER 12, 2024

As a result, patients receiving ESC-derived therapies must also take immunosuppressive drugs potentially for life. The process can yield a renewable stockpile of cells for everything from CAR-T cancer therapies to tissue and organ transplants. This can trigger an immune response that causes the body to reject these therapeutic cells.

Therapies 59

Therapies DNA Molecular Biology Immune Response 59

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Journal of Molecular Biology (1961). Gene Expression and Regulation. Nature Reviews Molecular Cell Biology (2008). Link Molecular Cloning Techniques , by AddGene. & Xie X.S.

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DNA Cell Biology Molecular Biology Engineering 95

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Journal of Molecular Biology (1961). Gene Expression and Regulation. Nature Reviews Molecular Cell Biology (2008). Link Molecular Cloning Techniques , by AddGene. & Xie X.S.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

NOVEMBER 1, 2024

I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. But looking ahead to the second bottleneck, what does it mean to say that biology is “complex”? It involves pragmatism and cultural sensitivity.

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