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Logistics in Focus: Orchestrating the Challenges of Cell Therapy

Conversations in Drug Development Trends

These advanced therapeutics harness the power of molecular biology to improve human health. Despite their exciting potential, the smooth operation of cell therapy development trials requires extraordinary orchestration, perfectly aligning the product and patient journeys.

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A surprising new role for a major immune regulator

Broad Institute

A surprising new role for a major immune regulator By Tom Ulrich August 7, 2023 Breadcrumb Home A surprising new role for a major immune regulator By Anne Trafton, MIT News August 7, 2023 Credit: RCSB Protein Data Bank A model of the human STING protein. Paper Cited Liu B, Carlson R, et al. Human STING is a proton channel.

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Scaling Phage Therapy

Codon

1 Yet even after more than two decades of research, media hype, and dozens of clinical trials and biotech start-ups that have come and gone, phage therapy has not scaled. No phage-based therapeutic has reached the latter stages of the clinical trial pipeline (where promising results lead to an expanded trial involving thousands of patients).

Therapies 124
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SRP-001: redefining pain treatment with a safer, non-opioid analgesic

Drug Target Review

SRP-001 targets the central nervous system (CNS) by producing N-arachidonoylaminophenol (AM404) in the midbrain’s periaqueductal grey (PAG) region, crucial for pain sensation and regulation. In Phase I clinical trials, SRP-001 showed no serious adverse events among 56 healthy volunteers, highlighting its safety.

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The essential role of recombinant phage display antibody libraries

Drug Target Review

3 This change signals a major shift away from animal use in drug safety regulation and encourages the use of alternative methods like organ-on-chip or other animal-free technologies. FDA no longer needs to require animal tests before human drug trials [Internet]. Methods in Molecular Biology. Journal of Molecular Biology.

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Gamma delta T cells: a rising star in cancer therapy

Drug Target Review

Preclinical research on γδ T cells has made great strides since the cells were first identified in the 1980s, with γδ T-cell therapies from several companies, including IN8bio, now in or nearing clinical trials for various cancers. Regulation of cutaneous malignancy by gammadelta T cells. References Fichtner A, Ravens S, Prinz I.

Therapies 105
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Alzheimer’s disease: driving advancements with precision medicine

Drug Target Review

We’re investigating powerful tools that may allow for an earlier – and biologically based – prediction of Alzheimer’s disease, which are being evaluated to help identify patients for clinical trials. Progress in molecular biology and translational science. link] Pugazhenthi, S. 2017, February 4). link] Smets, Bart, et al.

Disease 59