The Pharma Data

FEBRUARY 25, 2022

Several FDA-approved drugs – including for type 2 diabetes, hepatitis C and HIV – significantly reduce the ability of the Delta variant of SARS-CoV-2 to replicate in human cells, according to new research led by scientists at Penn State. 25) in the journal Communications Biology. .

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FDA Approval Molecular Biology FDA Virus 52

Codon

JULY 11, 2023

All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It is the untouchable foundation of molecular biology. The ribosome is a molecular printer that threads ‘beads’ onto a protein string. This is simple. And we want to subvert this.

RNA 64

RNA DNA Engineering Laboratories 64

Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. I am now at the end of a career that has comprised nearly 10 years of academic research and 35 years in biotechnology. Arrakis is the capstone of my career.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Drug Target Review

MAY 27, 2024

Caris Discovery, the therapeutic research arm of Caris Life Sciences, was launched to address the paucity of novel oncology drug targets and is uniquely poised to discover first-in-class ADC targets. Can you discuss any recent advancements or breakthroughs in ADC-related research or development that Caris has been involved in?

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Clinical Trials Science Molecular Biology Bioinformatics 59

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies 59

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Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Codon

JUNE 25, 2024

Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. Researchers use DNA cloning to make numerous copies of a gene, which can then be inserted into living cells to study how that gene functions or otherwise coax the cell to make proteins. However, E.

DNA 70

DNA RNA Laboratories Engineering 70

Drug Target Review

AUGUST 29, 2023

Another challenge I faced was to determine what field or subject to focus my PhD on, since so many fields interested me and even cancer biology is so broad. Once I decided to pursue cancer research, I explored subfields within it by working at Fox Chase Cancer Center for a couple years, which resulted in authoring a couple of papers.

Science 98

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Alta Sciences

MARCH 1, 2024

NM: One of the specializations of our research facility in Seattle, WA, is gene therapy. Our biomarker team has a number of cytokine and complement panels designed to detect and quantify these changes in research subjects. Q: How do Your Preclinical and Bioanalytical Teams Work Together to Accelerate Sponsors’ Gene Therapy Research?

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Drug Target Review

JUNE 11, 2024

Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. We had to pursue our research work with very limited resources and resolve to some creative solutions to get our experiments done, sometimes we even had to buy some of the reagents ourselves.

Engineering 64

Engineering Science Molecular Biology Doctors 64

Codon

JULY 11, 2023

All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It is the untouchable foundation of molecular biology. The ribosome is a molecular printer that threads ‘beads’ onto a protein string. This is simple. And we want to subvert this.

RNA 52

RNA DNA Engineering Laboratories 52

The Pharma Data

NOVEMBER 10, 2021

By creating genetically finagled mouse models and doing single cell RNA-sequencing, Feng and associates plant that Shp2 was needed by excrescence cells for HCC development, which validated and corroborated allowing that Shp2 presented an ideal target for new cancer curatives.

Disease 52

Disease Molecular Biology RNA Drugs 52

Codon

JULY 27, 2023

For a recent study, researchers edited 21 different genes in poplar trees, a species commonly used to make paper. The researchers studied trees with 70,000 different gene-editing combinations, just 0.5% ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.”

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

For a recent study, researchers edited 21 different genes in poplar trees, a species commonly used to make paper. The researchers studied trees with 70,000 different gene-editing combinations, just 0.5% ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.”

Therapies 52

Therapies RNA DNA Engineering 52

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. He was bestowed the 2024 NIH HEAL Director’s Trailblazer Award for this work.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

LifeSciVC

JULY 1, 2024

So when I was asked recently to share advice to a group of undergraduate students doing research at Penn State, I was drawn to the idea of connecting scientific principles to some life lessons. The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein.

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Science Immune Response Molecular Biology RNA 80

Codon

JUNE 26, 2023

Goodsell, Scripps Research and RCSB Protein Data Bank. And for another study, researchers engineered bacteriophage T4 to target and deliver payloads to human cells , simply by swapping around the proteins on their outer shells and then coating them in positively-charged lipid molecules. “Every query is like $2.” in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Goodsell, Scripps Research and RCSB Protein Data Bank. And for another study, researchers engineered bacteriophage T4 to target and deliver payloads to human cells , simply by swapping around the proteins on their outer shells and then coating them in positively-charged lipid molecules. “Every query is like $2.” in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

MARCH 12, 2023

But the technologies devised in the process of trying may revolutionize other areas of science, especially reproductive biology. Biology is a Burrito. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. 15 of 31.

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DNA Engineering Therapies RNA 52

Broad Institute

NOVEMBER 20, 2024

Now, researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have analyzed the entire mouse intestine, mapping gene expression and cell states and location in the healthy gut and in response to perturbations such as inflammation. “The

Regulations 84

Regulations Immune Response Molecular Biology Disease 84

Codon

NOVEMBER 1, 2024

Amodei also imagines the ways AI could accelerate biological research and yield miraculous cures in the 21st century; everything from the prevention and treatment of nearly all infectious and inherited diseases to the elimination of most cancers. Still, many of the bottlenecks slowing biology today are biophysical , rather than computational.

DNA 107

DNA RNA Molecular Biology Laboratories 107

Codon

JULY 10, 2024

But in the 1950s, at the dawn of molecular biology, scientists gained a new appreciation for it after searching for organisms that were easy to work with and quick to grow. 1 This singular organism has become the de facto microbe for molecular biology. Before World War II, few scientists used E. coli in their experiments.

Laboratories 75

Laboratories DNA Molecular Biology Engineering 75

Codon

AUGUST 10, 2023

Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Journal of Molecular Biology (1961). Nucleic Acids Research (2010).

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Journal of Molecular Biology (1961). Nucleic Acids Research (2010).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

DECEMBER 1, 2024

By Matthew Cobb The Central Dogma is a linchpin for understanding how cells work, and yet it is one of the most widely misunderstood concepts in molecular biology. Many students are taught that the Central Dogma is simply “DNA → RNA → protein.”

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RNA DNA Molecular Biology Virus 117