Molecular Biology, RNA and Virus - Drug Discovery Digest

Phages could help to tackle antimicrobial resistance

Drug Target Review

DECEMBER 7, 2023

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. He continued: “CBASS cyclases look a lot like cGAS, so they have to be sensing something.

RNA

RNA Immune Response DNA Molecular Biology

Repurposing FDA-approved drugs may help combat COVID-19

The Pharma Data

FEBRUARY 25, 2022

. “The SARS-CoV-2 vaccines target the spike protein, but this protein is under strong selection pressure and, as we have seen with Omicron, can undergo significant mutations,” said Joyce Jose, assistant professor of biochemistry and molecular biology, Penn State. 25) in the journal Communications Biology. .

FDA Approval

FDA Approval FDA Molecular Biology Virus

Enhancing gene therapy with Circio

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies

Therapies RNA Protein Expression DNA

Merkin Prize in Biomedical Technology awarded to F. William Studier for development of widely used protein- and RNA-production platform

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

RNA

RNA Production Molecular Biology Laboratories

Q&A With Dr. Norbert Makori and Pierre Jolicoeur: The Benefits of Combining Preclinical and Bioanalytical for Your Gene Therapy Studies

Alta Sciences

MARCH 1, 2024

PJ: At Altasciences, we have a range of leading-edge platforms that include ligand binding assays (LBA), NAb, TAb, flow cytometry, and ELISpot, as well as on-site molecular biology instrumentation such as Bio-Rad’s ddPCR system, the NanoDropTM One spectrophotometer, and dedicated polymerase chain reaction (PCR) chambers.

Therapies

Therapies Laboratories Molecular Biology RNA

The future outlook for mRNA therapies

Drug Discovery World

APRIL 30, 2024

Messenger RNA (mRNA) has come into focus within the drug discovery and development as an exciting tool to deliver genetic information. mRNA is a molecule made up of a single strand of ribonucleic acid (RNA). Today, there are several other categories of RNA therapeutics with drugs already approved or currently in development.

Therapies

Therapies RNA Vaccine Small Molecule

Battling antibiotic resistance in the lab and the clinic

Broad Institute

JANUARY 30, 2024

He has also emerged in recent years as a skilled and relatable science communicator, renowned for his efforts at Broad and beyond during the COVID-19 pandemic to unpack the fast-moving research on the new virus in an accessible way and give practical advice about masking, vaccines, and other public health measures.

Hospitals

Hospitals Medical Schools Virus Science

Codon Digest: Seeing Colors After Gene Therapy

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. How do transcription factors couple up with the correct RNA molecule?

Therapies

Therapies RNA DNA Engineering

Codon Digest: Seeing Colors After Gene Therapy

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. How do transcription factors couple up with the correct RNA molecule?

Therapies

Therapies RNA DNA Engineering

Johns Hopkins Researchers Identify CRISPR Dimmer

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.

Research

Research RNA Molecular Biology Small Molecule

Breaking the Speed Limit on Cell Division

Codon

JUNE 25, 2024

Proteins are colored blue and RNA molecules are colored orange and yellow. RNA and proteins comprise each ribosome, but the cell synthesizes these two biomolecules at different rates. Recall that a typical ribosome in bacteria is built from 50 proteins and 3 strands of RNA. The large and small ribosome subunits.

DNA

DNA RNA Laboratories Engineering

Synthetic biology tools advancing and accelerating drug discovery efforts

Drug Discovery World

NOVEMBER 15, 2022

As such, the synthesis of DNA oligonucleotides for routine molecular biology applications is often outsourced to service provider companies that operate DNA synthesisers to meet these demands. . It’s now possible to programme cell-free systems to make RNA and proteins that interact with each other,” Dr Laohakunakorn continues.

DNA

DNA Engineering Drugs Vaccine

Codon: Notes on Progress #2

Codon

MARCH 12, 2023

But the technologies devised in the process of trying may revolutionize other areas of science, especially reproductive biology. Biology is a Burrito. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. 15 of 31.

DNA

DNA Engineering RNA Therapies

Codon Digest: Hackathon Prize Winners

Codon

JUNE 26, 2023

A phage is a virus that infects bacteria. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. “Anyone with a few years of molecular biology training could do this if so inclined.”

DNA

DNA Therapies Engineering Clinical Trials

Codon Digest: Hackathon Prize Winners

Codon

JUNE 26, 2023

A phage is a virus that infects bacteria. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. “Anyone with a few years of molecular biology training could do this if so inclined.”

DNA

DNA Therapies Engineering Clinical Trials

Drug Discovery Digest

Phages could help to tackle antimicrobial resistance

Repurposing FDA-approved drugs may help combat COVID-19

Trending Sources

Enhancing gene therapy with Circio

Merkin Prize in Biomedical Technology awarded to F. William Studier for development of widely used protein- and RNA-production platform

Q&A With Dr. Norbert Makori and Pierre Jolicoeur: The Benefits of Combining Preclinical and Bioanalytical for Your Gene Therapy Studies

The future outlook for mRNA therapies

Battling antibiotic resistance in the lab and the clinic

Codon Digest: Seeing Colors After Gene Therapy

Codon Digest: Seeing Colors After Gene Therapy

Johns Hopkins Researchers Identify CRISPR Dimmer

Breaking the Speed Limit on Cell Division

Synthetic biology tools advancing and accelerating drug discovery efforts

Codon: Notes on Progress #2

Codon Digest: Hackathon Prize Winners

Codon Digest: Hackathon Prize Winners

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