Drug Discovery World

FEBRUARY 27, 2023

For founders planning to launch their start-ups, specifically drug developers, there needs to be sound, foundational science with promising data that will enable you to push further down the drug discovery pipeline. DS: You were recognised in the 2023 Forbes’ 30 under 30 for Science.

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Drug Target Review

AUGUST 29, 2024

What potential advantages does the CD5 modulation strategy offer over traditional CAR-T therapies? MR : Chimeric antigen receptor T-cell (CAR-T) therapy is very effective in treating patients with B-cell lymphoma, leukemia, and multiple myeloma, where we have six FDA-approved drugs.

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Therapies Treatment Engineering Molecular Biology 59

Drug Discovery World

AUGUST 1, 2024

Founded by Daniel Lucy, Archie Wall and Professor Ed Tate, the company is in the process of spinning out of Imperial College London and aims to translate 20 years of groundbreaking research into impactful therapies for patients. Their technology automates pathology analysis, improving accuracy and enabling early detection.

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Molecular Biology DNA Research Treatment 147

Drug Discovery World

MAY 6, 2024

Thanks to a prestigious academic legacy, Europe has long been a dominant region for life sciences. Europe is traditionally a life sciences powerhouse, with a strong tradition in pharmaceutical discovery. The oldest, still active pharmaceutical company worldwide, Merck, started life in 1668 in Darmstadt, Germany. billion ($7.9

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Drug Target Review

JUNE 19, 2024

The mission of Lineage Cell Therapeutics is to deliver on some of the early promises of cell therapy. Cell therapy as a concept is a wonderful idea, but many of the early efforts never generated the kind of clinical data that gets people excited and leads to new medicines. In some cases, cell therapy can be curative for the patient.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

Drug Discovery World

OCTOBER 11, 2023

The DDW Turning Science into Business Summit, ‘Cancer research opportunities and advances ’ will feature an expert panel discussion on new drug discovery and development concepts and tools in cancer research. The free two-hour Summit, hosted by DDW, will take place online on 16 November at 7AM PDT / 10AM EDT / 3PM GMT / 4PM CET.

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Drug Discovery World

MAY 1, 2024

Many of the best-selling drugs in 2023 were monoclonal antibody (mAB) therapies, including Keytruda (pembrolizumab), Humira (adalimumab), and Dupixent (dupilumab) 1. Hammond says: “Many of the most popular drugs in 2023 are mAb-based therapies, which we predict will continue in 2024.

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Drug Target Review

FEBRUARY 19, 2024

I always found science fascinating, but I really fell in love with it in high school when I was introduced to biochemistry and molecular biology. It was then that I knew I wanted to dedicate my career to science. Biochemistry and molecular biology fascinated me in school. BECOME A ROLE MODEL!

Molecular Biology 110

Molecular Biology Science Protein Expression Production 110

Alta Sciences

MARCH 1, 2024

Norbert Makori and Pierre Jolicoeur: The Benefits of Combining Preclinical and Bioanalytical for Your Gene Therapy Studies pmjackson Fri, 03/01/2024 - 22:20 Recent advances in gene therapy have allowed for diseases to be approached differently. q: How can Altasciences support sponsors’ Gene Therapy Programs?

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Drug Discovery World

JULY 23, 2024

Dr Daniel Turner, Chief Scientific Officer, Enhanc3D Genomics, outlines how 3D genomics offers a radically novel approach to address challenges in drug target discovery and how it can affect change in drug target identification, cell therapy and personalised medicine. Science 2012;337(6099):1190-1195. Nature 2014:1-6.

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DNA Disease Regulations Molecular Biology 130

Drug Target Review

MAY 27, 2024

Caris Life Sciences® (Caris) has been at the forefront of precision medicine. Caris Discovery, the therapeutic research arm of Caris Life Sciences, was launched to address the paucity of novel oncology drug targets and is uniquely poised to discover first-in-class ADC targets.

Clinical Trials 59

Clinical Trials Science Molecular Biology Bioinformatics 59

DrugBank

MAY 15, 2024

This method was more about serendipity than science. But as molecular biology has advanced, so too has our approach to finding new drugs. 5 This period also saw the rise of biologics in the 1980s, which have played a crucial role in modern therapies, particularly for diseases like cancer.

Small Molecule 83

Small Molecule Molecular Biology Drugs Disease 83

Drug Discovery World

DECEMBER 26, 2023

Otsuka Pharmaceutical and Ionis Pharmaceuticals Otsuka Pharmaceutical and RNA therapy company Ionis have entered into a licence agreement for Otsuka to acquire exclusive marketing rights to Ionis’ hereditary angioedema (HAE) drug candidate donidalorsen in Europe. His research focuses on immunotherapies for patients with breast cancer.

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Small Molecule Drugs Molecular Biology Bioinformatics 130

Drug Discovery World

NOVEMBER 2, 2023

KS: I have been involved in the field of computational molecular biophysics for many years and more recently in protein design with my work at the European Molecular Biology Laboratory (EMBL). RA: Could you tell me about the launch of AION Labs’ second start-up DenovAI?

Molecular Biology 208

Molecular Biology Disease Licensing Licensing 208

Drug Target Review

SEPTEMBER 22, 2023

Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. Prior to joining Beckman Coulter Life Sciences, she worked as a Research Associate and Postdoctoral Fellow at Indiana University School of Medicine.

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Clinical Research Research Drug Development Molecular Biology 116

Drug Target Review

FEBRUARY 26, 2024

Regarding therapy resistant melanomas, why is the alteration of the epigenetic landscape considered significant, and what has been lacking in terms of validated targetable epigenetic mechanisms? What is remarkable here is that we show that the addition of corin to BRAFi-resistant tumour cells resensitises them to BRAFi therapies.

Therapies 59

Therapies Molecular Biology Regulations Medical Schools 59

Drug Target Review

MARCH 15, 2024

Not for use in diagnostic procedures About the author © 2023 KP Visions #Revvity Dr Anis H Khimani Senior Strategy Leader, Life Sciences strategy group, Revvity, Inc. Anis works within the strategy group in Life Sciences at Revvity, Inc. Cell Gene Therapy Insights 2017; 3(2), 131-158, 10.18609/cgti.2017.014. Biotechnol Prog.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105

The Pharma Data

MARCH 16, 2022

Johnsson has been Director of the Chemical Biology Department at the Max Planck Institute for Medical Research in Heidelberg since 2017. Prior to taking up this appointment, he was Professor at the Institute of Chemical Sciences and Engineering at EFPL, the Swiss Federal Institute of Technology Lausanne.

Molecular Biology 52

Molecular Biology Cell Biology Science Laboratories 52

The Pharma Data

FEBRUARY 25, 2022

. “The SARS-CoV-2 vaccines target the spike protein, but this protein is under strong selection pressure and, as we have seen with Omicron, can undergo significant mutations,” said Joyce Jose, assistant professor of biochemistry and molecular biology, Penn State. 25) in the journal Communications Biology.

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FDA Approval FDA Molecular Biology Virus 52

Drug Discovery World

AUGUST 3, 2023

These categories are: Analytical Heroes, Processing Pros, Plant Science Pioneers, R&D Trailblazers and Inspirational Mentors. My mission is to see cannabis regulators understand basic science and to consult experienced scientists to refine regulations. There are five categories, each containing five cannabis scientists.

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Clinical Trials Regulations Production FDA 130

Drug Discovery World

APRIL 30, 2024

Reece Armstrong explores the potential and future opportunities for mRNA-based therapies. For instance, consider how at the end of 2018, the mRNA therapies market was valued at $3.43 At the start of 2024, the first patients in a clinical trial investigating an mRNA cancer therapy were dosed.

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The Pharma Data

OCTOBER 27, 2021

On joining the Board, Hal will become a member of the Science Committee which supports the Board in its oversight and scrutiny of the Company’s R&D strategy and annual performance targets. GSK is a science-led global healthcare company. Dr Hal Dietz is Victor A. He is the founder and scientific advisor to Blade Therapeutics.

Molecular Biology 52

Molecular Biology Science Medical Schools Disease 52

Vial

MARCH 1, 2024

Leading Global CROs To advance new therapies, pharma, biotech, and medical device sponsors engage CROs to help navigate the complex landscape of drug development and regulatory pathways and to manage clinical trials efficiently, ethically, and in compliance with good clinical practice ( GCP ) standards. with full-year revenue of US$23.04

Clinical Trials 52

Clinical Trials Clinical Research Laboratories Trials 52

The Pharma Data

NOVEMBER 23, 2020

The investigation into the smuggling activities is being led by China’s ministry of science and technology along with related authorities. Two years after its founding, Legend Biotech tied up with Johnson & Johnson to develop the anti-BCMA CAR-T therapy ciltacabtagene autoleucel (cilta-cel). as a director of molecular biology.

Government 52

Government Molecular Biology Regulations Laboratories 52

Drug Target Review

APRIL 8, 2024

How have recent advancements in immune checkpoint blockade therapy affected outcomes for primary NSCLC? Dr Govindan : Even though immunotherapy and chemotherapy given after surgery improve the overall survival, as Dr Cote said, many may not need those therapies and a good number of them recur despite post operative systemic therapies.

Hospitals 52

Hospitals Therapies Clinical Trials Molecular Biology 52

Drug Discovery World

APRIL 11, 2023

By bridging the gap and bringing world-leading AI researchers into the life sciences, we have the opportunity to create safer and more effective therapeutics for a broad range of diseases.” We will also see improved gene therapies and advanced CRISPR guide RNA design tools. It is excellent timing to combine these technologies.”

RNA 130

RNA Small Molecule Engineering Disease 130

Drug Target Review

NOVEMBER 8, 2023

Problem w/ CTs and foundational understanding of Vittoria: can you explore the current limitations of cell therapies and the challenges faced by patients and providers? Currently, only a small percentage of cancers can be effectively treated with cell therapies, and there is little diversity in the currently approved products.

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Therapies Engineering Molecular Biology Treatment 116

Drug Target Review

FEBRUARY 28, 2024

Over the past 25 years, T-cell therapies have gained significant ground in the treatment of cancer. Preclinical research on γδ T cells has made great strides since the cells were first identified in the 1980s, with γδ T-cell therapies from several companies, including IN8bio, now in or nearing clinical trials for various cancers.

Therapies 105

Therapies Engineering Molecular Biology Immune Response 105

Codon

FEBRUARY 13, 2024

Tom Ireland writes about the companies and technologies that are reimagining phage therapy. Soon after its publication, scientists, journalists, and investors were revisiting ‘phage therapy’ as a promising alternative to our failing antibiotics. Read it on our website here. Illustration by David S. Fast forward to 2023.

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Therapies Virus DNA Clinical Trials 121

The Pharma Data

JANUARY 4, 2021

. chPD1 will be used in the Company’s proprietary chimeric antigen receptor therapy (CAR-T) platform using gamma-delta T-cells (GD-T). Barber’s work will give Kiromic a significant acceleration in the clinical development of its therapy platform and an even more significant advantage over its competitors.

Molecular Biology 40

Molecular Biology Therapies Immune Response Science 40

Drug Discovery World

JANUARY 23, 2023

Kevin Hemphill, R&D Manager at PerkinElmer’s Horizon Discovery explores how base editing has emerged as an attractive gene editing option for researchers wanting to develop stem cell-based therapies. The first in-person iPSC-derived regenerative therapy trial took place at Kyoto University, Japan.

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Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Having an interest in the emerging field of gene therapy, I did a brief postdoc with Richard Mulligan at the Whitehead Institute.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Drug Discovery World

NOVEMBER 9, 2023

Peter O’Callaghan, PhD, Head of Expression System Sciences, Biologics and Licensing, Lonza, on: ‘Solve bispecific heavy-light chain mispairing with bYlok technology’. James Cooke, PhD, Associate Director, Bicycle Therapeutics, on: ‘Engineering bicyclic peptides for precision targeted medicine’.

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Engineering Therapies Protein Production Science 130

Drug Discovery World

NOVEMBER 7, 2023

From a personal development perspective, it is an excellent blend of manual technique, high-tech instrumentation, application of basic science, investigation into translational models, and interaction with intelligent and visionary thinkers. I believe I was the best student when I was studying molecular biology —and Italian —simultaneously.

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Research Molecular Biology Science Laboratories 147

Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. But what happens if you restore these cone cells, using gene therapy? ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.”

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Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. But what happens if you restore these cone cells, using gene therapy? ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.”

Therapies 52

Therapies RNA DNA Engineering 52

Agency IQ

JANUARY 19, 2024

This process is more thoroughly covered in guidances on gene therapy and vaccine development, and in other guidelines, such as the ICH Q5B Guideline. a recombinant protein or gene therapy packaged via AAV virus) which has been produced by the cells, in addition to other debris such as the remaining media and the remnants of the cells.

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Virus Science Production FDA 40