Drug Target Review

FEBRUARY 19, 2024

I always found science fascinating, but I really fell in love with it in high school when I was introduced to biochemistry and molecular biology. It was then that I knew I wanted to dedicate my career to science. Biochemistry and molecular biology fascinated me in school. BECOME A ROLE MODEL!

Molecular Biology 110

Molecular Biology Science Protein Expression Production 110

Alta Sciences

JUNE 11, 2024

My Attendance at the 2024 Boston Society Cell and Gene Therapy Conference pmjackson Tue, 06/11/2024 - 20:49 , via Wikimedia Commons" data-entity-type="file" data-entity-uuid="c7a7fa8b-b2fe-4d84-a75e-d1ba3a4e2caf" src="[link] width="742" height="249" loading="lazy" /> Ecm85, CC BY-SA 3.0

Therapies 52

Therapies Molecular Biology Immune Response Science 52

DrugBank

MAY 15, 2024

This method was more about serendipity than science. But as molecular biology has advanced, so too has our approach to finding new drugs. 5 This period also saw the rise of biologics in the 1980s, which have played a crucial role in modern therapies, particularly for diseases like cancer.

Small Molecule 98

Small Molecule Molecular Biology Drugs Disease 98

Drug Target Review

AUGUST 29, 2024

What potential advantages does the CD5 modulation strategy offer over traditional CAR-T therapies? MR : Chimeric antigen receptor T-cell (CAR-T) therapy is very effective in treating patients with B-cell lymphoma, leukemia, and multiple myeloma, where we have six FDA-approved drugs.

Therapies 59

Therapies Treatment Engineering Molecular Biology 59

Drug Target Review

SEPTEMBER 22, 2023

Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. Prior to joining Beckman Coulter Life Sciences, she worked as a Research Associate and Postdoctoral Fellow at Indiana University School of Medicine.

Clinical Research 116

Clinical Research Research Drug Development Molecular Biology 116

Broad Institute

JANUARY 30, 2024

More bottles on the medicine shelf would help, but Bhattacharyya, who’s now also a research scientist, realized that science might lead to better tools for diagnosing and treating such challenging cases. FROM STARS TO CELLS Bhattacharyya’s interest in science began not in the lab, but in the sky.

Hospitals 137

Hospitals Virus Medical Schools Science 137

Drug Target Review

MARCH 15, 2024

Not for use in diagnostic procedures About the author © 2023 KP Visions #Revvity Dr Anis H Khimani Senior Strategy Leader, Life Sciences strategy group, Revvity, Inc. Anis works within the strategy group in Life Sciences at Revvity, Inc. Cell Gene Therapy Insights 2017; 3(2), 131-158, 10.18609/cgti.2017.014. Biotechnol Prog.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105

Alta Sciences

MARCH 1, 2024

Norbert Makori and Pierre Jolicoeur: The Benefits of Combining Preclinical and Bioanalytical for Your Gene Therapy Studies pmjackson Fri, 03/01/2024 - 22:20 Recent advances in gene therapy have allowed for diseases to be approached differently. q: How can Altasciences support sponsors’ Gene Therapy Programs?

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Drug Target Review

MAY 27, 2024

Caris Life Sciences® (Caris) has been at the forefront of precision medicine. Caris Discovery, the therapeutic research arm of Caris Life Sciences, was launched to address the paucity of novel oncology drug targets and is uniquely poised to discover first-in-class ADC targets.

Clinical Trials 59

Clinical Trials Science Molecular Biology Bioinformatics 59

Broad Institute

JUNE 21, 2023

said Vamsi Mootha , senior author of the study, an institute member at the Broad, professor of systems biology and medicine at Harvard Medical School, and professor of molecular biology at Massachusetts General Hospital. Even with profound ataxia, these mice can still, under the correct therapeutic regimen, reverse course.”

Treatment 98

Treatment Disease Molecular Biology Medical Schools 98

Drug Target Review

AUGUST 29, 2023

It’s also where I got exposed to career options beyond academia and learned about Flagship Pioneering, a venture creation firm that conceives, resources, and builds life science bio platform companies in health care and sustainability. One of my mentors asked me if I was ready to fail 90 percent of the time.

Science 98

Science Disease Molecular Biology Therapies 98

Broad Institute

AUGUST 16, 2023

These large-scale biobanks with an open science philosophy are transforming what is possible in biomedical research and are accelerating the pace of discovery across the community,” Neale said.

DNA 98

DNA Molecular Biology Disease Regulations 98

Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. But what happens if you restore these cone cells, using gene therapy? ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.”

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. But what happens if you restore these cone cells, using gene therapy? ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.”

Therapies 52

Therapies RNA DNA Engineering 52

The Pharma Data

MARCH 16, 2022

Johnsson has been Director of the Chemical Biology Department at the Max Planck Institute for Medical Research in Heidelberg since 2017. Prior to taking up this appointment, he was Professor at the Institute of Chemical Sciences and Engineering at EFPL, the Swiss Federal Institute of Technology Lausanne.

Cell Biology 52

Cell Biology Molecular Biology Science Laboratories 52

The Pharma Data

JANUARY 6, 2021

(“CytoDel” or “the Company”), a privately-held corporation, today announces the publication of preclinical data on the Company’s lead product, Cyto-111, in the peer-reviewed journal, Science Translational Medicine. This is a landmark study in converting the power of lethal botulinum neurotoxins into therapies. Südhof, M.D.,

Science 52

Science Molecular Biology Treatment Production 52

The Pharma Data

FEBRUARY 25, 2022

. “The SARS-CoV-2 vaccines target the spike protein, but this protein is under strong selection pressure and, as we have seen with Omicron, can undergo significant mutations,” said Joyce Jose, assistant professor of biochemistry and molecular biology, Penn State. 25) in the journal Communications Biology.

FDA Approval 52

FDA Approval FDA Molecular Biology Virus 52

Drug Target Review

FEBRUARY 26, 2024

Regarding therapy resistant melanomas, why is the alteration of the epigenetic landscape considered significant, and what has been lacking in terms of validated targetable epigenetic mechanisms? What is remarkable here is that we show that the addition of corin to BRAFi-resistant tumour cells resensitises them to BRAFi therapies.

Therapies 59

Therapies Molecular Biology Regulations Medical Schools 59

The Pharma Data

NOVEMBER 23, 2020

The investigation into the smuggling activities is being led by China’s ministry of science and technology along with related authorities. Two years after its founding, Legend Biotech tied up with Johnson & Johnson to develop the anti-BCMA CAR-T therapy ciltacabtagene autoleucel (cilta-cel). as a director of molecular biology.

Government 52

Government Molecular Biology Regulations Laboratories 52

Drug Target Review

JUNE 11, 2024

When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. In math and life and physical sciences, women now make up nearly half of the workforce.

Engineering 64

Engineering Science Molecular Biology Doctors 64

The Pharma Data

SEPTEMBER 15, 2020

The companies will receive priority admission or renewal for one year of lab bench space with access to core facilities at the MBC BioLabs life sciences incubator, including access to Amgen ‘s scientific experts and business leaders to help advance their scientific programs.

Targeted Protein Degradation 52

Targeted Protein Degradation Molecular Biology Small Molecule Science 52

Drug Target Review

OCTOBER 25, 2024

At Johnson & Johnson, our differentiated Alzheimer’s disease research program is focused on leveraging the latest advancements in precision medicine, data science and digital health to help make earlier diagnosis an option and help treat the right patient with the right treatment at the right time. link] Pugazhenthi, S. 2017, February 4).

Disease 59

Disease Clinical Trials Therapies Science 59

The Pharma Data

JANUARY 13, 2021

Germany-based Cevec Pharmaceuticals GmbH signed a licensing agreement with Biogen for the use of its proprietary ELEVECTA Technology for the manufacturing of adeno-associated virus (AAV) vectors for gene therapy applications. The deal will provide Biogen the rights to use the technology across their portfolio of gene therapy products.

Licensing 52

Licensing Licensing Clinical Trials Vaccine 52

Drug Target Review

APRIL 8, 2024

How have recent advancements in immune checkpoint blockade therapy affected outcomes for primary NSCLC? Dr Govindan : Even though immunotherapy and chemotherapy given after surgery improve the overall survival, as Dr Cote said, many may not need those therapies and a good number of them recur despite post operative systemic therapies.

Hospitals 52

Hospitals Therapies Clinical Trials Molecular Biology 52

Vial

MARCH 1, 2024

Leading Global CROs To advance new therapies, pharma, biotech, and medical device sponsors engage CROs to help navigate the complex landscape of drug development and regulatory pathways and to manage clinical trials efficiently, ethically, and in compliance with good clinical practice ( GCP ) standards. with full-year revenue of US$23.04

Clinical Trials 52

Clinical Trials Clinical Research Trials Laboratories 52

The Pharma Data

JANUARY 4, 2021

. chPD1 will be used in the Company’s proprietary chimeric antigen receptor therapy (CAR-T) platform using gamma-delta T-cells (GD-T). Barber’s work will give Kiromic a significant acceleration in the clinical development of its therapy platform and an even more significant advantage over its competitors.

Therapies 40

Therapies Molecular Biology Immune Response Science 40

Codon

DECEMBER 17, 2023

Molecular biology, as the field came to be called 3 , pushed biology from an object of study, driven forward by gentleman scientists and precocious country clergymen, into a tool with which to solve urgent problems. At least six CAR-T cancer therapies have now garnered F.D.A.

Engineering 52

Engineering Molecular Biology Doctors Therapies 52

Agency IQ

JANUARY 19, 2024

This process is more thoroughly covered in guidances on gene therapy and vaccine development, and in other guidelines, such as the ICH Q5B Guideline. a recombinant protein or gene therapy packaged via AAV virus) which has been produced by the cells, in addition to other debris such as the remaining media and the remnants of the cells.

Virus 40

Virus Science Production FDA 40

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Having an interest in the emerging field of gene therapy, I did a brief postdoc with Richard Mulligan at the Whitehead Institute.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. Nevertheless, phage therapy did have a stint in the U.S. I’ll post an update soon. coli in mice.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. Nevertheless, phage therapy did have a stint in the U.S. I’ll post an update soon. coli in mice.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

MARCH 12, 2023

But the technologies devised in the process of trying may revolutionize other areas of science, especially reproductive biology. Biology is a Burrito. I’ve also seen the Watson/Crick DNA model in London’s Science Museum, but I think this tRNA model is much better. percent chance.)

DNA 52

DNA Engineering Therapies RNA 52

The Pharma Data

SEPTEMBER 17, 2020

This is the focus of vaccines in development and convalescent plasma therapy. About Roche Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The molecular biology of coronaviruses. Science 369:77-81; DOI: 10.1126/science.abc1932. Academic Press.

Vaccine 52

Vaccine Virus Clinical Trials Immune Response 52

Codon

JUNE 18, 2024

Jensen, reported a much more detailed analysis of gas vesicles in the journal Science. Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. Bowen and T.E. The deployment of ultrasound and gas vesicles could change this.

Engineering 66

Engineering Laboratories International Clinical Trials 66

The Pharma Data

OCTOBER 27, 2021

On joining the Board, Hal will become a member of the Science Committee which supports the Board in its oversight and scrutiny of the Company’s R&D strategy and annual performance targets. GSK is a science-led global healthcare company. Dr Hal Dietz is Victor A. He is the founder and scientific advisor to Blade Therapeutics.

Molecular Biology 52

Molecular Biology Science Medical Schools Disease 52

Drug Target Review

MARCH 25, 2025

The convergence of advanced research tools, a growing understanding of tumour biology, and urgent unmet patient needs makes this the perfect moment to reignite focus on DNA Damage Response in cancer therapy. the perfect intersection of science & technology Several factors have aligned to make this an ideal moment to refocus on DDR.

DNA 52

DNA Therapies Clinical Trials Clinical Pharmacology 52