LifeSciVC

AUGUST 5, 2024

The Nimbus experience to date is that this merger of scientific disciplines shows less benefit in speed and much clearer benefit in a wider range of tractable drug discovery targets and enhancement in the quality of small molecule clinical candidates developed. One final parallel to 2001.

Molecular Biology 90

Molecular Biology Production Small Molecule Drug Development 90

Drug Discovery World

MAY 1, 2024

Meanwhile, Richard Hammond, CTO of Sphere Fluidics, comments that the development of mAb-based therapies has rapidly taken off within the last few decades, which he owes to advances in molecular biology and high-throughput screening technologies.

FDA Approval 148

FDA Approval Therapies FDA Molecular Biology 148

Drug Discovery World

JANUARY 26, 2023

The financing was led by Playground Global, with participation from 8VC, Factory HQ, Greylock, NotBoring, AME Cloud Ventures, and renowned angel investors including GitHub ex-CEO Nat Friedman, Doug Mohr, Curai CEO Neal Khosla, and UC Berkeley professor and Arc Institute Co-founder Patrick Hsu. “To create effective and safer small molecules against (..)

RNA 130

RNA Small Molecule Engineering Disease 130

Drug Discovery World

FEBRUARY 27, 2023

For RNA, we’ve seen its success with Covid-19 vaccines and the approval of the first-ever RNA-targeting small molecule, risdiplam, for treating spinal muscular atrophy (SMA). Do you have any therapeutic targets in mind for your first small molecule drug candidate? Is there anything currently in the pipeline?

RNA 130

RNA Science Small Molecule Engineering 130

Drug Target Review

JUNE 19, 2024

Transplanting cells could prove to be more beneficial than treating a particular condition with a small molecule or an antibody, and that really speaks to the power of cell therapy. Just like small molecules and antibodies, cell therapies are changing how we treat patients.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

The Pharma Data

NOVEMBER 9, 2021

Elias is part of a National Institutes of Health-funded laboratory that focuses on the cell and molecular biology of lung injury and repair. They found that this “therapeutic” antibody, as well as another small molecule, powerfully blocked the induction of the ACE2 receptor.

Small Molecule 52

Small Molecule Virus Molecular Biology Disease 52

Drug Discovery World

APRIL 3, 2023

AT : The major interest we see is in the targeted delivery of therapeutic molecules. We are working with partners to develop delivery vehicles for small molecule payloads as next-generation precision chemotherapy and supporting partners with targeted delivery and cell penetration for gene therapies.

Science 130

Science Molecular Biology Therapies Small Molecule 130

Drug Target Review

DECEMBER 7, 2023

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. He continued: “CBASS cyclases look a lot like cGAS, so they have to be sensing something.

RNA 59

RNA Immune Response DNA Molecular Biology 59

Drug Discovery World

NOVEMBER 17, 2022

Lu Rahman selects some recent synthetic biology innovations and the potential they hold to benefit drug discovery. . The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape.

Engineering 130

Engineering Molecular Biology Synthetic Chemistry DNA 130

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Drug Discovery World

OCTOBER 16, 2023

1 The power of TPD stems from small molecules commonly referred to as degraders. 2 This is about to change as technological advances in proteomics instrumentation and software now enables researchers to screen extensive small-molecule libraries for degraders of pathogenic proteins that were previously considered ‘undruggable’.

Targeted Protein Degradation 148

Targeted Protein Degradation Small Molecule Molecular Biology Treatment 148

Drug Discovery World

APRIL 30, 2024

It’s worth noting that the approach of small molecules interacting with mRNA biology represents a relatively new and potentially broader and more effective strategy.

Therapies 130

Therapies RNA Vaccine Small Molecule 130

Drug Target Review

APRIL 19, 2024

Sibylla’s scientific founders come from very different scientific fields that do not usually speak to each other, such as theoretical physics, molecular biology and pharmaceutical chemistry. And so, I have been the managerial co-founder and CEO of Sibylla since 2017. This multidisciplinary approach is at the heart of Sibylla.

Molecular Biology 111

Molecular Biology Pharmaceuticals Small Molecule Research 111

DrugBaron

FEBRUARY 16, 2021

Small molecules are well-suited to inhibiting enzymes, such as kinases or proteases, but they struggle to block protein:protein interactions. That changed in the late 1980s, with the invention of phage-display libraries by Greg Winter and John McCafferty, also in the Cambridge-based Laboratory of Molecular Biology.

Molecular Biology 130

Molecular Biology Small Molecule Engineering Laboratories 130

Drug Discovery World

JULY 25, 2022

For example, we often identify endogenous ligands and natural allosteric bindings sites that can be used as putative sites for small molecules. OMass retains biological complexity and interrogates this complexity at high-resolution to gain insights invisible to cell-based assays and stripped-out of traditional cell-free approaches.

Cell Based Assays 130

Cell Based Assays Drugs Pharmaceutical Companies Molecular Biology 130

The Pharma Data

JANUARY 19, 2021

Joshua Modell, an author on the paper and assistant professor of molecular biology and genetics at the Johns Hopkins University School of Medicine, said the lab will next explore how tracr-L is regulated in bacteria, which could lead to a regulatable guide RDA – “one this is silenced until you can turn its activity on or up.”.

Research 52

Research RNA Molecular Biology Small Molecule 52

Elrig

APRIL 29, 2024

Fascinated by the potential of AI in medical research, I transitioned to BenevolentAI in early 2023 as a Biology Project Leader. There, I supported AI-enabled DD efforts in their small molecule portfolio. Bioinformatics is all about bringing together different areas of knowledge.

Bioinformatics 59

Bioinformatics Molecular Biology Drugs Cell Based Assays 59

Drug Discovery World

NOVEMBER 15, 2022

As such, the synthesis of DNA oligonucleotides for routine molecular biology applications is often outsourced to service provider companies that operate DNA synthesisers to meet these demands. . Engineering biosensors for specific functions . Biosensors have long been used as valuable tools for designing therapeutic strategies.

DNA 246

DNA Engineering Drugs Vaccine 246

The Pharma Data

SEPTEMBER 15, 2020

In a revolution of therapeutic approaches, Trilomer® peptidomimetic binders combine the cell permeability and degradation resistance of small molecules with the large surface area of antibodies, allowing them to target both intracellular and extracellular targets.

Targeted Protein Degradation 52

Targeted Protein Degradation Molecular Biology Small Molecule Science 52

Drug Target Review

FEBRUARY 15, 2024

Advances in molecular biology have led to highly safe, efficient, and effective platforms, such as mRNA, that can be rapidly re-purposed for different pathogens, multiple pathogens, or new strains of evolving pathogens. The scientific challenges are enormous.

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Drug Development Virus Vaccine Government 122