DrugBank
MAY 15, 2024
But as molecular biology has advanced, so too has our approach to finding new drugs. Today, we're able to identify and target specific molecules involved in disease processes—a method that's much more like using a sniper rifle than throwing darts blindfolded. This method was more about serendipity than science.
DrugBaron
FEBRUARY 16, 2021
Small molecules are well-suited to inhibiting enzymes, such as kinases or proteases, but they struggle to block protein:protein interactions. That changed in the late 1980s, with the invention of phage-display libraries by Greg Winter and John McCafferty, also in the Cambridge-based Laboratory of Molecular Biology.
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The Pharma Data
NOVEMBER 19, 2020
The Company is also aiming to leverage the highly conserved structure of the SARS-CoV-2 M pro protease as a basis for the design of novel oral small molecules against predicted future variants of SARS-CoV-2 and other related human viruses.
LifeSciVC
AUGUST 5, 2024
The Nimbus experience to date is that this merger of scientific disciplines shows less benefit in speed and much clearer benefit in a wider range of tractable drug discovery targets and enhancement in the quality of small molecule clinical candidates developed. One final parallel to 2001.
Drug Target Review
JUNE 19, 2024
Transplanting cells could prove to be more beneficial than treating a particular condition with a small molecule or an antibody, and that really speaks to the power of cell therapy. Just like small molecules and antibodies, cell therapies are changing how we treat patients.
Drug Target Review
APRIL 19, 2024
Sibylla’s scientific founders come from very different scientific fields that do not usually speak to each other, such as theoretical physics, molecular biology and pharmaceutical chemistry. And so, I have been the managerial co-founder and CEO of Sibylla since 2017. This multidisciplinary approach is at the heart of Sibylla.
The Pharma Data
JANUARY 19, 2021
Joshua Modell, an author on the paper and assistant professor of molecular biology and genetics at the Johns Hopkins University School of Medicine, said the lab will next explore how tracr-L is regulated in bacteria, which could lead to a regulatable guide RDA – “one this is silenced until you can turn its activity on or up.”.
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