Broad Institute

JANUARY 30, 2024

He has also emerged in recent years as a skilled and relatable science communicator, renowned for his efforts at Broad and beyond during the COVID-19 pandemic to unpack the fast-moving research on the new virus in an accessible way and give practical advice about masking, vaccines, and other public health measures.

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Hospitals Medical Schools Virus Science 137

The Pharma Data

JANUARY 19, 2021

Joshua Modell, an author on the paper and assistant professor of molecular biology and genetics at the Johns Hopkins University School of Medicine, said the lab will next explore how tracr-L is regulated in bacteria, which could lead to a regulatable guide RDA – “one this is silenced until you can turn its activity on or up.”.

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Research RNA Molecular Biology Small Molecule 52

Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

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Therapies DNA Virus Clinical Trials 120

The Pharma Data

NOVEMBER 9, 2021

.” The findings not only answer important questions about key mechanisms of the complex SARS-CoV-2 virus, Elias said, but also have direct implications for the development of therapeutics to control the viral infection. “This means there will be less infection in the presence of this therapeutic FRG antibody.”

Small Molecule 52

Small Molecule Virus Molecular Biology Disease 52

Drug Target Review

MAY 22, 2024

In parallel, we are exploring the technical performance of circVec in other viral vectors, as well as non-viral approaches which we expect will surpass virus-based vector-format as the state-of-the-art solutions for gene therapy in the future. So far, we have successfully expressed circRNA from six different vector types.

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Therapies RNA Protein Expression DNA 59

Alta Sciences

MARCH 1, 2024

PJ: At Altasciences, we have a range of leading-edge platforms that include ligand binding assays (LBA), NAb, TAb, flow cytometry, and ELISpot, as well as on-site molecular biology instrumentation such as Bio-Rad’s ddPCR system, the NanoDropTM One spectrophotometer, and dedicated polymerase chain reaction (PCR) chambers.

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Therapies Laboratories Molecular Biology RNA 52

The Pharma Data

MARCH 25, 2022

Using electron cryo-microscopy, the researchers found that Fu2 naturally binds to two separate sites on the viral spike, thus inhibiting the virus’ ability to enter the host cell.

Molecular Biology 52

Molecular Biology Laboratories Cell Biology Science 52

Agency IQ

JANUARY 19, 2024

Prevention of viral contamination is especially important as it may not be apparent that cells have been contaminated with a virus using conventional detection methods. Likewise, the selection of a cell line that was developed using a virus increases the risk of potential viral contamination.

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Virus Science Production FDA 40

The Pharma Data

FEBRUARY 22, 2021

Before, she was associate professor at Cornell University in the Department of Molecular Biology and Genetics. In the Biology category Dr. Julia Mahamid (European Molecular Biology Laboratory (EMBL) in Heidelberg) was awarded. This success is also a testament for the value of global collaboration.

Molecular Biology 40

Molecular Biology Science Vaccine Laboratories 40

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Paper Cited Liu B, Carlson R, et al. Human STING is a proton channel. Online August 3, 2023.

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Regulations Clinical Trials Engineering DNA 91

The Pharma Data

SEPTEMBER 17, 2020

The new Elecsys Anti-SARS-CoV-2 S test can quantitatively measure the level of antibodies against SARS-CoV-2 in patients who have been exposed to the virus. 3 Knowing a given population’s seroprevalence is important in understanding how to contain the spread of the virus, as well as how to safely ease lockdown restrictions.

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Vaccine Virus Clinical Trials Immune Response 52

Codon

JUNE 13, 2024

The HK97 virus, for example, infects E. So how can a genome 50 times longer—equivalent to 2,000 kilometers of thread, or roughly the distance between Cairo and Rome—do the same? The New Caledonian fork fern has clearly found a solution to this problem. 2 The same cannot be said for viruses.

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DNA Molecular Biology Virus Cell Biology 59

The Pharma Data

NOVEMBER 19, 2020

The program is being led by Sosei Heptares and progressed in collaboration with multiple companies including Syngene International, Domainex, Fidelta, o2h Discovery, Piramal, WuXi AppTec and the MRC Laboratory of Molecular Biology.

Small Molecule 40

Small Molecule Structure Based Drug Design (SBDD) Molecular Biology International 40

Codon

JUNE 25, 2024

The researchers chose to discard genes that encode virus-sensing machinery because the cells would be grown in a sterile laboratory environment. Ultimately, no matter the model organism or where it comes from, molecular biology will probably never approach the speed of computer programming. The resulting strain of V.

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DNA RNA Laboratories Engineering 73

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. ” The tool was crafted with a virus, called GIL16.

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Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. ” The tool was crafted with a virus, called GIL16.

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Therapies RNA DNA Engineering 52

Codon

DECEMBER 1, 2024

By Matthew Cobb The Central Dogma is a linchpin for understanding how cells work, and yet it is one of the most widely misunderstood concepts in molecular biology. Temin showed that inhibition of DNA synthesis stopped the reproduction of this RNA virus, suggesting it somehow turned its RNA into DNA.

RNA 81

RNA DNA Molecular Biology Virus 81

Codon

JUNE 26, 2023

A phage is a virus that infects bacteria. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. “Anyone with a few years of molecular biology training could do this if so inclined.” ” Bacteriophages infect a bacterium.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

A phage is a virus that infects bacteria. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. “Anyone with a few years of molecular biology training could do this if so inclined.” ” Bacteriophages infect a bacterium.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Drug Target Review

FEBRUARY 15, 2024

Since the 20 th century, all known viral pandemics, including HIV, influenza, SARS CoV-1, SARS, CoV-1, and mpox, have resulted from a virus ‘spilling over’ from animals into humans. For example, scientists cannot accurately predict which town or village will have the next Nipah virus outbreak.

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Drug Development Virus Vaccine Government 122

Codon

MARCH 12, 2023

Base editor proteins were delivered into the mice using a virus, called AAV9. Berg’s work set the stage for the entirety of synthetic biology and genetic engineering. coli genes into a piece of simian virus DNA. I recently asked for recommendations of “classic” papers in molecular biology.

DNA 52

DNA Engineering Therapies RNA 52

The Pharma Data

DECEMBER 2, 2020

During his tenure at Genome Prairie, he also led the development of projects in genomics-based “reverse vaccinology” and developed an in vivo model of the Zika Virus infection. Dr. Pontarollo’s primary areas of research and technical expertise include Genomics, Molecular Biology, Vaccine development and Immunology.

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Vaccine Molecular Biology Trials Virus 52

The Pharma Data

JANUARY 13, 2021

Germany-based Cevec Pharmaceuticals GmbH signed a licensing agreement with Biogen for the use of its proprietary ELEVECTA Technology for the manufacturing of adeno-associated virus (AAV) vectors for gene therapy applications. based Mogrify Limited expanded its research collaboration with MRC Laboratory of Molecular Biology.

Licensing 52

Licensing Licensing Clinical Trials Vaccine 52

Codon

NOVEMBER 1, 2024

I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. But looking ahead to the second bottleneck, what does it mean to say that biology is “complex”?

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DNA RNA Molecular Biology Laboratories 109