How to Get Drugs Into the Brain
Drug Hunter
AUGUST 21, 2023
The use of in silico and in vitro assays alleviates ethical concerns on extensive animal research in keeping with the three Rs (Replacement, Reduction, Refinement). Researchers replaced the acidic sulfonamide motif with a benzylic pyridine ether, which significantly improved the K p. Figure 14: Optimization of an NMT inhibitor by DNDi.
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